Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 15/100

Failure Rate

10.5%

4 terminated/withdrawn out of 38 trials

Success Rate

88.2%

+1.7% vs industry average

Late-Stage Pipeline

32%

12 trials in Phase 3/4

Results Transparency

60%

18 of 30 completed trials have results

Key Signals

2 recruiting18 with results

Enrollment Performance

Analytics

Phase 1
14(36.8%)
Phase 2
12(31.6%)
Phase 3
12(31.6%)
38Total
Phase 1(14)
Phase 2(12)
Phase 3(12)

Activity Timeline

Global Presence

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Clinical Trials (38)

Showing 20 of 38 trials
NCT07268638Phase 2Recruiting

A Study of Praliciguat in Participants With Focal Segmental Glomerulosclerosis (FSGS)

Role: lead

NCT07429006Phase 1Recruiting

SAD and MAD Study of AKB-9090 in Healthy Adult Participants

Role: lead

NCT06520826Phase 3Active Not Recruiting

Vafseo Outcomes In-Center Experience

Role: collaborator

NCT06901505Phase 3Active Not Recruiting

To Evaluate the Efficacy of Three Times Weekly (TIW) Vadadustat Compared to Standard of Care ESA in Patients With Anemia of CKD Receiving In-Center Hemodialysis

Role: lead

NCT05082571Phase 3Withdrawn

Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease

Role: lead

NCT05082584Phase 3Withdrawn

Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease Naive to Erythropoiesis-Stimulating Agents

Role: lead

NCT05085275Phase 3Completed

Ferric Citrate for the Prevention of Renal Failure in Adults With Advanced Chronic Kidney Disease

Role: collaborator

NCT04313153Phase 3Completed

Trial Evaluating the Efficacy and Safety of Oral Vadadustat Once Daily (QD) and Three Times Weekly (TIW) for the Maintenance Treatment of Anemia in Hemodialysis Subjects Converting From Erythropoiesis-Stimulating Agents (ESAs)

Role: lead

NCT04707768Phase 3Completed

Study Evaluating the Efficacy and Safety of Dose Conversion From a Long-acting Erythropoiesis-stimulating Agent (Mircera®) to Three Times Weekly Oral Vadadustat for the Maintenance Treatment of Anemia in Hemodialysis Subjects

Role: lead

NCT03799627Phase 2Completed

Study of Vadadustat in Hemodialysis Participants With Anemia Switching From Epoetin Alfa

Role: lead

NCT03217591Phase 2Completed

A Study to Evaluate the Soluble Guanylate Cyclase (sGC) Stimulator IW-1973 in Diabetic Nephropathy / Diabetic Kidney Disease as Measured by Albuminuria

Role: lead

NCT03254485Phase 2Completed

A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF)

Role: lead

NCT01906489Phase 2Completed

20-Week Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia

Role: lead

NCT02865850Phase 3Completed

Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)

Role: lead

NCT01381094Phase 2Completed

42-Day Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia

Role: lead

NCT01235936Phase 2Completed

Safety and Efficacy Study for AKB-6548 in Participants With Chronic Kidney Disease and Anemia

Role: lead

NCT02260193Phase 2Completed

16-Week Repeat Oral Dose Study of AKB-6548 for Anemia in Participants With End Stage Renal Disease (ESRD) Requiring Chronic Hemodialysis

Role: lead

NCT04707573Phase 2Completed

Study to Assess the Safety and Pharmacokinetics of AKB-6548 in Participants With Chronic Kidney Disease (CKD), Stages 3 and 4

Role: lead

NCT02892149Phase 3Completed

Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Dialysis-dependent Chronic Kidney Disease (DD-CKD)

Role: lead

NCT02648347Phase 3Completed

Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease

Role: lead