Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 25/100

Failure Rate

6.7%

1 terminated/withdrawn out of 15 trials

Success Rate

93.3%

+6.8% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

79%

11 of 14 completed trials have results

Key Signals

11 with results

Enrollment Performance

Analytics

Phase 2
11(73.3%)
Phase 1
4(26.7%)
15Total
Phase 2(11)
Phase 1(4)

Activity Timeline

Global Presence

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Clinical Trials (15)

Showing 15 of 15 trials
NCT02229877Phase 1Completed

A Study to Assess the Effect of Intragastric pH and Fasting on the Pharmacokinetics of Gefapixant (AF-219/MK-7264)

Role: lead

NCT02492776Phase 1Completed

A Multiple-Dose Pharmacokinetics Study of Two Gefapixant (AF-219/MK-7264) Formulations

Role: lead

NCT02502097Phase 2Completed

A Study of Gefapixant (AF-219/MK-7264) in Participants With Idiopathic Pulmonary Fibrosis (IPF) With Persistent Cough (MK-7264-016)

Role: lead

NCT02397460Phase 2Completed

Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity (MK-7264-015)

Role: lead

NCT01993329Phase 2Completed

A Study to Evaluate the Effect of Gefapixant (AF-219/MK-7264) on Methacholine Hyper-reactivity in Participants With Asthma (MK-7264-009)

Role: lead

NCT01432730Phase 2Completed

A Study to Assess the Efficacy of Gefapixant (MK-7264/AF-219), in Participants With Chronic Cough (MK-7264-006)

Role: lead

NCT02349425Phase 2Completed

A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010)

Role: lead

NCT01569438Phase 2Terminated

The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Participants With Interstitial Cystitis /Bladder Pain Syndrome (MK-7264-005)

Role: lead

NCT02612610Phase 2Completed

A 12-Week Study in Participants With Refractory Chronic Cough (MK-7264-012)

Role: lead

NCT02612623Phase 2Completed

An 8-Week Refractory Chronic Cough Study (MK-7264-021)

Role: lead

NCT01554579Phase 2Completed

A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee

Role: lead

NCT02477709Phase 2Completed

A Study to Assess the Tolerability of a Single Dose of Gefapixant (AF-219/MK-7264) in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Role: lead

NCT02476890Phase 2Completed

Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)

Role: lead

NCT02790840Phase 1Completed

A Multiple-Dose Pharmacokinetics Study of Three Gefapixant (AF-219/MK-7264) Formulations

Role: lead

NCT02652936Phase 1Completed

A Pharmacokinetics Study of AF-130 in Healthy Subjects

Role: lead

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