Success Metrics

Clinical Success Rate
100.0%

Based on 8 completed trials

Completion Rate
100%(8/8)
Active Trials
8(44%)
Results Posted
100%(8 trials)

Phase Distribution

Ph phase_2
3
17%
Ph phase_1
15
83%

Phase Distribution

15

Early Stage

3

Mid Stage

0

Late Stage

Phase Distribution18 total trials
Phase 1Safety & dosage
15(83.3%)
Phase 2Efficacy & side effects
3(16.7%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

88.9%

8 of 9 finished

Non-Completion Rate

11.1%

1 ended early

Currently Active

8

trials recruiting

Total Trials

18

all time

Status Distribution
Active(9)
Completed(8)
Terminated(1)

Detailed Status

Completed8
Recruiting5
Active, not recruiting3
Withdrawn1
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
18
Active
8
Success Rate
100.0%
Most Advanced
Phase 2

Trials by Phase

Phase 115 (83.3%)
Phase 23 (16.7%)

Trials by Status

withdrawn16%
recruiting528%
not_yet_recruiting16%
completed844%
active_not_recruiting317%

Recent Activity

Clinical Trials (18)

Showing 18 of 18 trials
NCT05890963Phase 1

10E8.4/iMab Bispecific Antibody and VRC07-523LS Monoclonal Antibody in HIV-infected Adults

Active Not Recruiting
NCT02140255Phase 1

Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission

Recruiting
NCT05719441Phase 2

A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission

Recruiting
NCT06517693Phase 1

Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1

Recruiting
NCT05281510Phase 2

Study of VRC07-523LS, CAP256V2LS, and Vesatolimod, in Early Antiretroviral-treated HIV-1 Clade C-infected Women

Completed
NCT04983030Phase 1

Safety, Immunogenicity, Efficacy of Ad26.Mos4.HIV, MVA-BN-HIV and PGT121, PGDM1400, and VRC07-523LS in HIV-1-Infected Adults

Active Not Recruiting
NCT06987318Phase 1

A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection

Not Yet Recruiting
NCT06484335Phase 1

RV630 - Approach to Control HIV With Immune Enhancement and Vaccination (ACHIEV

Recruiting
NCT06508749Phase 1

The Tatelo Plus Study

Recruiting
NCT03735849Phase 1

Evaluating the Safety and Pharmacokinetics of VRC07-523LS in the Sera and Mucosae of Healthy, HIV-Uninfected Adult Participants

Completed
NCT03739996Phase 2

Long-Acting Cabotegravir Plus VRC-HIVMAB075-00-AB (VRC07-523LS) for Viral Suppression in Adults Living With HIV-1

Completed
NCT04340596Phase 1

Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control During Analytic Treatment Interruption

Active Not Recruiting
NCT04212091Phase 1

Evaluating the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of the Monoclonal Antibody PGT121.414.LS Administered Alone and in Combination With VRC07-523LS Via Intravenous or Subcutaneous Infusions in Healthy, HIV-uninfected Adult Participants

Completed
NCT05769569Phase 1

Safety and Efficacy of Neutralizing Antibodies and Vaccination for Induction of HIV Remission

Withdrawn
NCT03387150Phase 1

Evaluating the Safety and Serum Concentrations of a Human Monoclonal Antibody, VRC-HIVMAB075-00-AB (VRC07-523LS), Administered in Multiple Doses and Routes to Healthy, HIV-uninfected Adults

Completed
NCT02256631Phase 1

Evaluating the Safety and Pharmacokinetics of VRC01, VRC01LS, and VRC07-523LS, Potent Anti-HIV Neutralizing Monoclonal Antibodies, in HIV-1-Exposed Infants

Completed
NCT03928821Phase 1

Evaluating the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Combinations of Monoclonal Antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS Administered Via Intravenous Infusion in Healthy, HIV-uninfected Adult Participants

Completed
NCT03803605Phase 1

Study to Assess Safety and Activity of Combination Therapy of VRC07-523LS and Vorinostat on HIV-infected Persons

Completed

All 18 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
18