Success Metrics

Clinical Success Rate
71.7%

Based on 33 completed trials

Completion Rate
72%(33/46)
Active Trials
3(5%)
Results Posted
85%(28 trials)
Terminated
13(23%)

Phase Distribution

Ph phase_1
22
39%
Ph not_applicable
2
4%
Ph phase_3
6
11%
Ph phase_2
27
47%

Phase Distribution

22

Early Stage

27

Mid Stage

6

Late Stage

Phase Distribution57 total trials
Phase 1Safety & dosage
22(38.6%)
Phase 2Efficacy & side effects
27(47.4%)
Phase 3Large-scale testing
6(10.5%)
N/ANon-phased studies
2(3.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

66.0%

33 of 50 finished

Non-Completion Rate

34.0%

17 ended early

Currently Active

3

trials recruiting

Total Trials

57

all time

Status Distribution
Active(3)
Completed(33)
Terminated(17)
Other(4)

Detailed Status

Completed33
Terminated13
unknown4
Withdrawn4
Active, not recruiting2
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
57
Active
3
Success Rate
71.7%
Most Advanced
Phase 3

Trials by Phase

Phase 122 (38.6%)
Phase 227 (47.4%)
Phase 36 (10.5%)
N/A2 (3.5%)

Trials by Status

recruiting12%
active_not_recruiting24%
terminated1323%
completed3358%
unknown47%
withdrawn47%

Recent Activity

Clinical Trials (57)

Showing 20 of 57 trialsScroll for more
NCT01298323Phase 3

Study to Determine if Contacting Patients With MTC More Frequently Results in Earlier Detection and Treatment of Signs and Symptoms of AEs and Thus a Decrease in the Percentage of Time Patients Experience AEs During First 12 Months on Vandetanib Treatment

Completed
NCT04211337Phase 3

A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

Active Not Recruiting
NCT01582191Phase 1

Vandetanib and Everolimus in Treating Patients With Advanced or Metastatic Cancer

Completed
NCT02299999Phase 2

SAFIR02_Breast - Efficacy of Genome Analysis as a Therapeutic Decision Tool for Patients With Metastatic Breast Cancer

Active Not Recruiting
NCT00418886Phase 3

Efficacy Study Comparing ZD6474 in Combination With Pemetrexed and Pemetrexed Alone in 2nd Line NSCLC Patients

Completed
NCT06482086Phase 2

Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer

Recruiting
NCT00537095Phase 2

Efficacy and Safety of Vandetanib (ZD6474) in Patients With Metastatic Papillary or Follicular Thyroid Cancer

Completed
NCT02117167Phase 2

SAFIR02_Lung - Efficacy of Targeted Drugs Guided by Genomic Profiles in Metastatic NSCLC Patients

Completed
NCT04760288Phase 3

A Study of Pralsetinib Versus Standard of Care (SOC) for Treatment of RET-Mutated Medullary Thyroid Cancer (MTC).

Withdrawn
NCT01934335Phase 2

Effect of Vandetanib on Cellular Markers in Invasive Breast Cancer

Terminated
NCT03630120Phase 2

Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer

Terminated
NCT02495103Phase 1

Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma

Terminated
NCT01183559Phase 1

A Trial of ZD6474, Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiation Therapy Followed by Surgery

Completed
NCT01414426Phase 2

Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions

Completed
NCT00514046Phase 1

Vandetanib to Treat Children and Adolescents With Medullary Thyroid Cancer

Completed
NCT01823068Phase 2

Vandetanib in Advanced NSCLC With RET Rearrangement

Completed
NCT02239952Not Applicable

HGG-TCP (High Grade Glioma - Tumor Concentrations of Protein Kinase Inhibitors)

Unknown
NCT02015065Phase 2

Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors

Completed
NCT02638428Phase 2

Genomics-Based Target Therapy for Children With Relapsed or Refractory Malignancy

Unknown
NCT01191892Phase 2

Carboplatin and Gemcitabine Hydrochloride With or Without Vandetanib as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Urinary Tract Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
57