Success Metrics

Clinical Success Rate
77.8%

Based on 14 completed trials

Completion Rate
78%(14/18)
Active Trials
25(45%)
Results Posted
79%(11 trials)
Terminated
4(7%)

Phase Distribution

Ph early_phase_1
1
2%
Ph phase_1
22
40%
Ph phase_2
25
45%
Ph phase_3
4
7%

Phase Distribution

23

Early Stage

25

Mid Stage

4

Late Stage

Phase Distribution52 total trials
Early Phase 1First-in-human
1(1.9%)
Phase 1Safety & dosage
22(42.3%)
Phase 2Efficacy & side effects
25(48.1%)
Phase 3Large-scale testing
4(7.7%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

60.9%

14 of 23 finished

Non-Completion Rate

39.1%

9 ended early

Currently Active

25

trials recruiting

Total Trials

55

all time

Status Distribution
Active(29)
Completed(14)
Terminated(9)
Other(3)

Detailed Status

Completed14
Recruiting13
Active, not recruiting12
Withdrawn5
Not yet recruiting4
Terminated4

Development Timeline

Analytics

Development Status

Total Trials
55
Active
25
Success Rate
77.8%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (1.9%)
Phase 122 (42.3%)
Phase 225 (48.1%)
Phase 34 (7.7%)

Trials by Status

not_yet_recruiting47%
recruiting1324%
unknown24%
active_not_recruiting1222%
terminated47%
completed1425%
withdrawn59%
suspended12%

Recent Activity

Clinical Trials (55)

Showing 20 of 55 trialsScroll for more
NCT06157892Phase 2

A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors

Recruiting
NCT07494448Phase 1

Phase Ib/II Study of Zanidatamab Plus Tucatinib and Chemotherapy in HER2-Positive Advanced Breast Cancer

Not Yet Recruiting
NCT05132582Phase 3

A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer

Active Not Recruiting
NCT07413939Phase 2

RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive

Not Yet Recruiting
NCT03975647Phase 3

A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer

Active Not Recruiting
NCT03297606Phase 2

Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)

Recruiting
NCT04539938Phase 2

A Study of Tucatinib Plus Trastuzumab Deruxtecan in HER2+ Breast Cancer

Completed
NCT05748834Phase 2

Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer

Recruiting
NCT05323955Phase 2

Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients With aDvanced Human Epidermal Growth Factor Receptor 2+ brEast Cancer With the Addition of Tucatinib

Active Not Recruiting
NCT05230810Phase 1

Clinical Trial of Alpelisb and Tucatinib in Patients With PIK3CA-Mutant HER2+ Metastatic Breast Cancer.

Active Not Recruiting
NCT05253651Phase 3

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

Recruiting
NCT05382364Phase 1

Safety and Pharmacokinetics of Tucatinib (MK-7119) in Chinese Participants With Cancer (MK-7119-002)

Active Not Recruiting
NCT05672524Phase 2

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Recruiting
NCT07318389Early Phase 1

ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer

Not Yet Recruiting
NCT04430738Phase 2

Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers

Active Not Recruiting
NCT06686394Phase 1

Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

Recruiting
NCT05892068Phase 2

A Study of Tucatinib Given Before Surgery to People With HER2+ Cancers That Have Spread to the Brain

Active Not Recruiting
NCT05062889Phase 2

Exploiting Circulating Tumour DNA to Intensify the Postoperative Treatment Resected Colon Cancer Patients

Suspended
NCT05673928Phase 2

A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

Recruiting
NCT05458674Phase 2

Tucatinib+Trastuzumab+Eribulin in HER2+ MBC

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
55