Success Metrics

Clinical Success Rate
83.1%

Based on 74 completed trials

Completion Rate
83%(74/89)
Active Trials
69(39%)
Results Posted
74%(55 trials)
Terminated
15(8%)

Phase Distribution

Ph early_phase_1
5
3%
Ph phase_1
64
36%
Ph phase_3
15
8%
Ph not_applicable
1
1%
Ph phase_2
90
50%

Phase Distribution

69

Early Stage

90

Mid Stage

15

Late Stage

Phase Distribution175 total trials
Early Phase 1First-in-human
5(2.9%)
Phase 1Safety & dosage
64(36.6%)
Phase 2Efficacy & side effects
90(51.4%)
Phase 3Large-scale testing
15(8.6%)
N/ANon-phased studies
1(0.6%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

73.3%

74 of 101 finished

Non-Completion Rate

26.7%

27 ended early

Currently Active

69

trials recruiting

Total Trials

179

all time

Status Distribution
Active(71)
Completed(74)
Terminated(27)
Other(7)

Detailed Status

Completed74
Active, not recruiting36
Recruiting33
Terminated15
Withdrawn12
unknown7

Development Timeline

Analytics

Development Status

Total Trials
179
Active
69
Success Rate
83.1%
Most Advanced
Phase 3

Trials by Phase

Early Phase 15 (2.9%)
Phase 164 (36.6%)
Phase 290 (51.4%)
Phase 315 (8.6%)
N/A1 (0.6%)

Trials by Status

completed7441%
unknown74%
terminated158%
not_yet_recruiting21%
recruiting3318%
withdrawn127%
active_not_recruiting3620%

Recent Activity

Clinical Trials (179)

Showing 20 of 179 trialsScroll for more
NCT05027425Phase 2

Durvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver Transplant

Terminated
NCT07122089Phase 2

Evaluation of SIRT Followed by Immunotherapy for Treatment of Hepatocellular Carcinoma With Portal Vein Thrombosis

Recruiting
NCT04585490Phase 3

Personalized Escalation of Consolidation Treatment Following Chemoradiotherapy and Immunotherapy in Stage III NSCLC in Stage III NSCLC

Recruiting
NCT07166406Phase 3

Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial

Recruiting
NCT03482102Phase 2

Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer

Active Not Recruiting
NCT06710223Phase 1

Cryoablation and Arterial Infusion of SD-101 in Combination With Durvalumab and Tremelimumab

Recruiting
NCT05883644Phase 3

Durvalumab and Tremelimumab as First Line Treatment in Participants With Advanced Hepatocellular Carcinoma (HCC)

Active Not Recruiting
NCT03606967Phase 2

Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

Recruiting
NCT03043872Phase 3

Durvalumab ± Tremelimumab in Combination With Platinum Based Chemotherapy in Untreated Extensive-Stage Small Cell Lung Cancer (CASPIAN)

Active Not Recruiting
NCT02516241Phase 3

Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer

Active Not Recruiting
NCT04605731Phase 1

Durvalumab and Tremelimumab After Radioembolization for the Treatment of Unresectable, Locally Advanced Liver Cancer

Active Not Recruiting
NCT07391670Phase 1

A Phase I Dose Escalation and Dose Expansion Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Durvalumab

Recruiting
NCT06855225Phase 2

A Phase II Study of Single Tremelimumab With Regular Interval Durvalumab Plus Gemcitabine and Cisplatin in Locally Advanced Unresectable/Metastatic Combined Hepatocellular-cholangiocarcinoma

Not Yet Recruiting
NCT03317158Phase 1

Modern Immunotherapy in BCG-Unresponsive, BCG-Relapsing and High Risk BCG-Naive Non-Muscle Invasive Urothelial Carcinoma of the Bladder

Recruiting
NCT06117891

An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery

Recruiting
NCT07288034Phase 2

Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

Recruiting
NCT04960709Phase 3

Treatment Combination of Durvalumab, Tremelimumab and Enfortumab Vedotin or Durvalumab and Enfortumab Vedotin in Patients With Muscle Invasive Bladder Cancer Ineligible to Cisplatin or Who Refuse Cisplatin

Active Not Recruiting
NCT04034927Phase 2

Testing the Addition of an Immunotherapy Drug, Tremelimumab, to the PARP Inhibition Drug, Olaparib, for Recurrent Ovarian, Fallopian Tube or Peritoneal Cancer

Active Not Recruiting
NCT02888743Phase 2

Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer

Active Not Recruiting
NCT03923270Phase 1

Radiotherapy and Durvalumab/Durvalumab Combo (Tremelimumab/Olaparid) for Small Cell Lung Cancer

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
179