Success Metrics

Clinical Success Rate
83.1%

Based on 74 completed trials

Completion Rate
83%(74/89)
Active Trials
70(39%)
Results Posted
77%(57 trials)
Terminated
15(8%)

Phase Distribution

Ph phase_1
64
36%
Ph phase_2
90
50%
Ph phase_3
15
8%
Ph early_phase_1
5
3%
Ph not_applicable
1
1%

Phase Distribution

69

Early Stage

90

Mid Stage

15

Late Stage

Phase Distribution175 total trials
Early Phase 1First-in-human
5(2.9%)
Phase 1Safety & dosage
64(36.6%)
Phase 2Efficacy & side effects
90(51.4%)
Phase 3Large-scale testing
15(8.6%)
N/ANon-phased studies
1(0.6%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

73.3%

74 of 101 finished

Non-Completion Rate

26.7%

27 ended early

Currently Active

70

trials recruiting

Total Trials

179

all time

Status Distribution
Active(71)
Completed(74)
Terminated(27)
Other(7)

Detailed Status

Completed74
Active, not recruiting42
Recruiting28
Terminated15
Withdrawn12
unknown7

Development Timeline

Analytics

Development Status

Total Trials
179
Active
70
Success Rate
83.1%
Most Advanced
Phase 3

Trials by Phase

Early Phase 15 (2.9%)
Phase 164 (36.6%)
Phase 290 (51.4%)
Phase 315 (8.6%)
N/A1 (0.6%)

Trials by Status

terminated158%
unknown74%
completed7441%
active_not_recruiting4223%
withdrawn127%
recruiting2816%
not_yet_recruiting11%

Recent Activity

Clinical Trials (179)

Showing 20 of 179 trialsScroll for more
NCT03606967Phase 2

Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

Recruiting
NCT02453282Phase 3

Phase III Open Label First Line Therapy Study of MEDI 4736 (Durvalumab) With or Without Tremelimumab Versus SOC in Non Small-Cell Lung Cancer (NSCLC)

Active Not Recruiting
NCT03026062Phase 2

Durvalumab and Tremelimumab in Treating Participants With Recurrent or Refractory Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Completed
NCT02519348Phase 2

A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Advanced Hepatocellular Carcinoma

Active Not Recruiting
NCT04034927Phase 2

Testing the Addition of an Immunotherapy Drug, Tremelimumab, to the PARP Inhibition Drug, Olaparib, for Recurrent Ovarian, Fallopian Tube or Peritoneal Cancer

Active Not Recruiting
NCT02888743Phase 2

Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer

Active Not Recruiting
NCT03581487Phase 1

Durvalumab, Tremelimumab, and Selumetinib in Treating Participants With Recurrent or Stage IV Non-small Cell Lung Cancer

Completed
NCT06710223Phase 1

Cryoablation and Arterial Infusion of SD-101 in Combination With Durvalumab and Tremelimumab

Active Not Recruiting
NCT01843374Phase 2

Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma

Active Not Recruiting
NCT04395079Phase 2

Brachytherapy With Durvalumab or Tremelimumab for the Treatment of Patients With Platinum-Resistant, Refractory, Recurrent, or Metastatic Gynecological Malignancies

Active Not Recruiting
NCT03075527Phase 2

A Phase 2 Study of Durvalumab in Combination With Tremelimumab in Malignant Pleural Mesothelioma

Terminated
NCT03043872Phase 3

Durvalumab ± Tremelimumab in Combination With Platinum Based Chemotherapy in Untreated Extensive-Stage Small Cell Lung Cancer (CASPIAN)

Active Not Recruiting
NCT03317158Phase 1

Modern Immunotherapy in BCG-Unresponsive, BCG-Relapsing and High Risk BCG-Naive Non-Muscle Invasive Urothelial Carcinoma of the Bladder

Active Not Recruiting
NCT03847649Phase 2

A Phase II Study of Durvalumab Treatment - Substudy A: In Patients Who Discontinued Prior Checkpoint Therapy Due to Immune Related Toxicity - Substudy B: For Continued Treatment (+/- Tremelimumab) of Patients Previously Enrolled to Completed CCTG Studies

Recruiting
NCT06921785Phase 3

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

Recruiting
NCT02516241Phase 3

Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer

Active Not Recruiting
NCT07391670Phase 1

A Phase I Dose Escalation and Dose Expansion Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Durvalumab

Recruiting
NCT05301842Phase 3

Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC

Active Not Recruiting
NCT06824363Early Phase 1

ProofPrincip IntraTu TCells SinglDoseImmunCheckpoinInhib Gastro-Esophage Adenocarcinoma w/ARID1a Mu

Recruiting
NCT06117891

An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery

Active Not Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
179