Success Metrics

Clinical Success Rate
67.8%

Based on 59 completed trials

Completion Rate
68%(59/87)
Active Trials
61(35%)
Results Posted
81%(48 trials)
Terminated
28(16%)

Phase Distribution

Ph phase_2
73
41%
Ph early_phase_1
1
1%
Ph phase_4
3
2%
Ph not_applicable
1
1%
Ph phase_3
9
5%
Ph phase_1
80
45%

Phase Distribution

81

Early Stage

73

Mid Stage

12

Late Stage

Phase Distribution167 total trials
Early Phase 1First-in-human
1(0.6%)
Phase 1Safety & dosage
80(47.9%)
Phase 2Efficacy & side effects
73(43.7%)
Phase 3Large-scale testing
9(5.4%)
Phase 4Post-market surveillance
3(1.8%)
N/ANon-phased studies
1(0.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

59.0%

59 of 100 finished

Non-Completion Rate

41.0%

41 ended early

Currently Active

61

trials recruiting

Total Trials

176

all time

Status Distribution
Active(65)
Completed(59)
Terminated(41)
Other(11)

Detailed Status

Completed59
Active, not recruiting36
Terminated28
Recruiting25
Withdrawn13
unknown10

Development Timeline

Analytics

Development Status

Total Trials
176
Active
61
Success Rate
67.8%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.6%)
Phase 180 (47.9%)
Phase 273 (43.7%)
Phase 39 (5.4%)
Phase 43 (1.8%)
N/A1 (0.6%)

Trials by Status

suspended11%
recruiting2514%
not_yet_recruiting42%
unknown106%
active_not_recruiting3620%
terminated2816%
completed5934%
withdrawn137%

Recent Activity

Clinical Trials (176)

Showing 20 of 176 trialsScroll for more
NCT03975829Phase 4

Pediatric Long-Term Follow-up and Rollover Study

Active Not Recruiting
NCT02910700Phase 2

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

Active Not Recruiting
NCT03340506Phase 4

Dabrafenib and/or Trametinib Rollover Study

Recruiting
NCT07468071Phase 1

Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments

Recruiting
NCT07110246Phase 2

Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas

Recruiting
NCT04940052Phase 3

Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Previously Treated Patients With Metastatic, Radio-active Iodine Refractory BRAF V600E Mutation Positive Differentiated Thyroid Cancer

Active Not Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT03899155Phase 2

Pan Tumor Rollover Study

Recruiting
NCT02642042Phase 2

Trametinib and Docetaxel in Treating Patients With Recurrent or Stage IV KRAS Mutation Positive Non-small Cell Lung Cancer

Active Not Recruiting
NCT02079740Phase 1

Trametinib and Navitoclax in Treating Patients With Advanced or Metastatic Solid Tumors

Active Not Recruiting
NCT03190915Phase 2

Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

Active Not Recruiting
NCT06475989Phase 3

Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

Recruiting
NCT03825289Phase 1

Trametinib and Hydroxychloroquine in Treating Patients With Pancreatic Cancer

Terminated
NCT01989585Phase 1

Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanoma

Active Not Recruiting
NCT03784014Phase 3

Molecular Profiling of Advanced Soft-tissue Sarcomas

Completed
NCT07549646Phase 2

24VA021; VATCH Trametinib for Ras/MAPK Pathway VAs

Active Not Recruiting
NCT03363217Phase 2

Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway.

Active Not Recruiting
NCT04116541Phase 2

A Study Evaluating the Activity of Anti-cancer Treatments Targeting Tumor Molecular Alterations/Characteristics in Advanced / Metastatic Tumors.

Recruiting
NCT01682083Phase 3

Dabrafenib With Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma (COMBI-AD).

Completed
NCT03149029Phase 2

Abbreviated MAPK Targeted Therapy Plus Pembrolizumab in Melanoma

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
176