Success Metrics

Clinical Success Rate
67.4%

Based on 60 completed trials

Completion Rate
67%(60/89)
Active Trials
60(34%)
Results Posted
80%(48 trials)
Terminated
29(16%)

Phase Distribution

Ph phase_2
73
41%
Ph not_applicable
1
1%
Ph phase_1
80
45%
Ph early_phase_1
1
1%
Ph phase_3
9
5%
Ph phase_4
3
2%

Phase Distribution

81

Early Stage

73

Mid Stage

12

Late Stage

Phase Distribution167 total trials
Early Phase 1First-in-human
1(0.6%)
Phase 1Safety & dosage
80(47.9%)
Phase 2Efficacy & side effects
73(43.7%)
Phase 3Large-scale testing
9(5.4%)
Phase 4Post-market surveillance
3(1.8%)
N/ANon-phased studies
1(0.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

58.8%

60 of 102 finished

Non-Completion Rate

41.2%

42 ended early

Currently Active

60

trials recruiting

Total Trials

176

all time

Status Distribution
Active(64)
Completed(60)
Terminated(42)
Other(10)

Detailed Status

Completed60
Active, not recruiting34
Terminated29
Recruiting26
Withdrawn13
unknown10

Development Timeline

Analytics

Development Status

Total Trials
176
Active
60
Success Rate
67.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.6%)
Phase 180 (47.9%)
Phase 273 (43.7%)
Phase 39 (5.4%)
Phase 43 (1.8%)
N/A1 (0.6%)

Trials by Status

completed6034%
unknown106%
withdrawn137%
recruiting2615%
active_not_recruiting3419%
not_yet_recruiting42%
terminated2916%

Recent Activity

Clinical Trials (176)

Showing 20 of 176 trialsScroll for more
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT03091257Phase 1

A Study of Dabrafenib and/or Trametinib in Patients With Relapsed and/or Refractory Multiple Myeloma

Active Not Recruiting
NCT02642042Phase 2

Trametinib and Docetaxel in Treating Patients With Recurrent or Stage IV KRAS Mutation Positive Non-small Cell Lung Cancer

Active Not Recruiting
NCT03899155Phase 2

Pan Tumor Rollover Study

Recruiting
NCT07110246Phase 2

Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas

Recruiting
NCT03065387Phase 1

Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

Terminated
NCT03190915Phase 2

Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

Active Not Recruiting
NCT03225664Phase 1

Trametinib and Pembrolizumab in Treating Patients With Recurrent Non-small Cell Lung Cancer That Is Metastatic, Unresectable, or Locally Advanced

Active Not Recruiting
NCT03087071Phase 2

Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal Cancer

Active Not Recruiting
NCT07468071Phase 1

Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments

Recruiting
NCT03340506Phase 4

Dabrafenib and/or Trametinib Rollover Study

Recruiting
NCT04116541Phase 2

A Study Evaluating the Activity of Anti-cancer Treatments Targeting Tumor Molecular Alterations/Characteristics in Advanced / Metastatic Tumors.

Recruiting
NCT03085056Early Phase 1

Trametinib in Combination With Paclitaxel in the Treatment of Anaplastic Thyroid Cancer

Active Not Recruiting
NCT03975829Phase 4

Pediatric Long-Term Follow-up and Rollover Study

Active Not Recruiting
NCT04238624Phase 2

Study of Cemiplimab Combined With Dabrafenib and Trametinib in People With Anaplastic Thyroid Cancer

Active Not Recruiting
NCT01972347Phase 2

Neoadjuvant Dabrafenib + Trametinib for AJCC Stage IIIB-C BRAF V600 Mutation Positive Melanoma

Completed
NCT04940052Phase 3

Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Previously Treated Patients With Metastatic, Radio-active Iodine Refractory BRAF V600E Mutation Positive Differentiated Thyroid Cancer

Active Not Recruiting
NCT06475989Phase 3

Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

Recruiting
NCT01979523Phase 2

Trametinib With or Without GSK2141795 in Treating Patients With Metastatic Uveal Melanoma

Active Not Recruiting
NCT04485559Phase 1

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
176