Success Metrics

Clinical Success Rate
66.7%

Based on 6 completed trials

Completion Rate
67%(6/9)
Active Trials
3(16%)
Results Posted
50%(3 trials)
Terminated
3(16%)

Phase Distribution

Ph phase_1
15
79%
Ph phase_2
4
21%

Phase Distribution

15

Early Stage

4

Mid Stage

0

Late Stage

Phase Distribution19 total trials
Phase 1Safety & dosage
15(78.9%)
Phase 2Efficacy & side effects
4(21.1%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

60.0%

6 of 10 finished

Non-Completion Rate

40.0%

4 ended early

Currently Active

3

trials recruiting

Total Trials

19

all time

Status Distribution
Active(4)
Completed(6)
Terminated(4)
Other(5)

Detailed Status

Completed6
Terminated3
Suspended3
Active, not recruiting3
unknown2
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
19
Active
3
Success Rate
66.7%
Most Advanced
Phase 2

Trials by Phase

Phase 115 (78.9%)
Phase 24 (21.1%)

Trials by Status

not_yet_recruiting15%
unknown211%
withdrawn15%
terminated316%
suspended316%
active_not_recruiting316%
completed632%

Recent Activity

Clinical Trials (19)

Showing 19 of 19 trials
NCT02333162Phase 1

Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant

Suspended
NCT03494569Phase 1

Total Marrow and Lymphoid Irradiation, Fludarabine, and Melphalan Before Donor Stem Cell Transplant in Treating Participants With High-Risk Acute Leukemia or Myelodysplastic Syndrome

Suspended
NCT03467386Phase 1

Total Marrow and Lymphoid Irradiation Before Donor Transplant and Cyclophosphamide in Treating Patients With Acute Myeloid Leukemia

Suspended
NCT03121014Phase 2

Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes

Active Not Recruiting
NCT07078721Phase 2

Efficacy and Safety of UCBT With TMI -Based Conditioning Regimen for Adults With Refractory/Relapsed Aplastic Anemia

Not Yet Recruiting
NCT02094794Phase 2

Total Marrow and Lymphoid Irradiation and Chemotherapy Before DSCT in Treating Patients With High-Risk ALL or AML

Active Not Recruiting
NCT05139004Phase 1

90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome

Active Not Recruiting
NCT02446964Phase 1

Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia

Completed
NCT00112827Phase 1

Melphalan and Radiation Therapy Followed By Lenalidomide in Treating Patients Who Are Undergoing Autologous Stem Cell Transplant for Stage I, Stage II, or Stage III Multiple Myeloma

Completed
NCT01163357Phase 1

Bortezomib, Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant For High-Risk Stage I or II Multiple Myeloma

Completed
NCT02043847Phase 1

TMI With HD Mel in ASCT for R/R Multiple Myeloma (BMT-03)

Completed
NCT02129582Phase 1

Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies

Completed
NCT02043860Phase 1

Total Marrow Irradiation With High Dose Melphalan Prior to Autologous Transplant for Multiple Myeloma

Terminated
NCT03100877Phase 1

Melphalan, Total Marrow Irradiation, and Autologous Stem Cell Transplantation in Treating Patients With High-Risk Multiple Myeloma

Withdrawn
NCT00623077Phase 1

MT2004-30: Tomotherapy for Solid Tumors

Terminated
NCT00686556Phase 1

Total Marrow Irradiation for Refractory Acute Leukemia

Completed
NCT00800059Phase 1

Total Marrow Irradiation & Autologous Stem Cell Transplantation for Relapsed or Refractory Myeloma

Unknown
NCT00800150Phase 1

Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Hematological Cancer That Has Not Responded to Treatment

Terminated
NCT01665014Phase 2

Total Marrow Irradiation and High-dose Melphalan for Double Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma

Unknown

All 19 trials loaded

Drug Details

Intervention Type
RADIATION
Total Trials
19