Success Metrics

Clinical Success Rate
80.0%

Based on 8 completed trials

Completion Rate
80%(8/10)
Active Trials
9(41%)
Results Posted
138%(11 trials)
Terminated
2(9%)

Phase Distribution

Ph phase_1
12
55%
Ph phase_3
1
5%
Ph phase_2
9
41%

Phase Distribution

12

Early Stage

9

Mid Stage

1

Late Stage

Phase Distribution22 total trials
Phase 1Safety & dosage
12(54.5%)
Phase 2Efficacy & side effects
9(40.9%)
Phase 3Large-scale testing
1(4.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

72.7%

8 of 11 finished

Non-Completion Rate

27.3%

3 ended early

Currently Active

9

trials recruiting

Total Trials

22

all time

Status Distribution
Active(9)
Completed(8)
Terminated(3)
Other(2)

Detailed Status

Completed8
Recruiting5
Active, not recruiting4
unknown2
Terminated2
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
22
Active
9
Success Rate
80.0%
Most Advanced
Phase 3

Trials by Phase

Phase 112 (54.5%)
Phase 29 (40.9%)
Phase 31 (4.5%)

Trials by Status

unknown29%
completed836%
active_not_recruiting418%
recruiting523%
terminated29%
withdrawn15%

Recent Activity

Clinical Trials (22)

Showing 20 of 22 trialsScroll for more
NCT06031688Phase 2

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

Recruiting
NCT05782361Phase 1

POTENT - Tepotinib in Combination With Pembrolizumab in NSCLC

Active Not Recruiting
NCT02864992Phase 2

Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)

Active Not Recruiting
NCT06083857Phase 1

PhI/II Study of Amivantamab and Tepotinib Combo in MET-altered Non-small Cell Lung Cancer

Active Not Recruiting
NCT03940703Phase 2

A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2)

Active Not Recruiting
NCT06106802Phase 2

Lazertinib & Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatment

Recruiting
NCT06908993Phase 3

Tepotinib vs Standard Treatment in Patients With Advanced MET Exon 14 Mutated Non-Small Cell Lung Cancer Previously Treated

Recruiting
NCT03546608Phase 1

Tepotinib Hepatic Impairment Trial

Completed
NCT05159245Phase 2

The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs

Recruiting
NCT05120960Phase 1

A Phase 1a/1b Study to Determine the Recommended Phase 2 Dose, of Tepotinib in Participants With MET Alterations and Brain Tumors

Withdrawn
NCT05213481Phase 1

Tepotinib Drug-Drug Interaction Study With Carbamazepine in Healthy Participants

Completed
NCT02925234Phase 2

The Drug Rediscovery Protocol (DRUP Trial)

Recruiting
NCT04739358Phase 1

CNS Dose Escalation/Expansion of Tepotinib in MET-driven NSCLC

Terminated
NCT04591431Phase 2

The Rome Trial From Histology to Target: the Road to Personalize Target Therapy and Immunotherapy

Unknown
NCT03492437Phase 1

Effect of Tepotinib on the PK of the P-gp Substrate Dabigatran Etexilate

Completed
NCT03628339Phase 1

Effect of Tepotinib on PK of CYP3A Substrate Midazolam

Completed
NCT03531762Phase 1

Effect of a Proton Pump Inhibitor on the PK of Tepotinib

Completed
NCT04515394Phase 2

Study of Tepotinib Combined With Cetuximab in Participants With Left-Sided RAS/BRAF Wild Type Metastatic Colorectal Cancer (PERSPECTIVE)

Terminated
NCT01982955Phase 1

Tepotinib With Gefitinib in Participants With Locally Advanced or Metastatic NSCLC (INSIGHT)

Completed
NCT02115373Phase 1

c-Met Second-Line Hepatocellular Carcinoma

Completed

Drug Details

Intervention Type
DRUG
Total Trials
22