Success Metrics

Clinical Success Rate
72.7%

Based on 16 completed trials

Completion Rate
73%(16/22)
Active Trials
5(13%)
Results Posted
69%(11 trials)
Terminated
6(16%)

Phase Distribution

Ph not_applicable
4
11%
Ph phase_3
6
16%
Ph phase_4
1
3%
Ph phase_2
15
39%
Ph phase_1
9
24%
Ph early_phase_1
2
5%

Phase Distribution

11

Early Stage

15

Mid Stage

7

Late Stage

Phase Distribution37 total trials
Early Phase 1First-in-human
2(5.4%)
Phase 1Safety & dosage
9(24.3%)
Phase 2Efficacy & side effects
15(40.5%)
Phase 3Large-scale testing
6(16.2%)
Phase 4Post-market surveillance
1(2.7%)
N/ANon-phased studies
4(10.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

61.5%

16 of 26 finished

Non-Completion Rate

38.5%

10 ended early

Currently Active

5

trials recruiting

Total Trials

38

all time

Status Distribution
Active(5)
Completed(16)
Terminated(10)
Other(7)

Detailed Status

Completed16
Terminated6
unknown6
Recruiting4
Withdrawn4
Suspended1

Development Timeline

Analytics

Development Status

Total Trials
38
Active
5
Success Rate
72.7%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (5.4%)
Phase 19 (24.3%)
Phase 215 (40.5%)
Phase 36 (16.2%)
Phase 41 (2.7%)
N/A4 (10.8%)

Trials by Status

suspended13%
recruiting411%
active_not_recruiting13%
terminated616%
completed1642%
unknown616%
withdrawn411%

Recent Activity

Clinical Trials (38)

Showing 20 of 38 trialsScroll for more
NCT03127774Phase 2

Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma

Active Not Recruiting
NCT05382338Phase 3

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Recruiting
NCT04847063Phase 1

Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies

Recruiting
NCT06288152Not Applicable

Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney Transplantation

Recruiting
NCT05756660Early Phase 1

Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy

Suspended
NCT05018221Phase 3

Better Evidence and Translation for Calciphylaxis

Recruiting
NCT02527213Phase 3

Double-blind Trial of Sodium Thiosulfate for the Treatment of Pain Associated With Calcific Uremic Arteriolopathy

Withdrawn
NCT04213794Early Phase 1

Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients

Terminated
NCT03092518Phase 2

Heated Intraperitoneal Chemotherapy and Gastrectomy for Gastric Cancer With Positive Peritoneal Cytology

Completed
NCT03267277Phase 2

Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis

Completed
NCT04541355Phase 2

Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin

Completed
NCT00716976Phase 3

Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy

Completed
NCT00074165Phase 2

Treating Patients With Recurrent PCNSL With Carboplatin/BBBD and Adding Rituxan To The Treatment Regimen

Terminated
NCT02624479Phase 1

Pharmacokinetic Study to Investigate the Bioavailability and Tolerability of 3 Oral Formulations of Sodium Thiosulfate

Withdrawn
NCT00075387Phase 2

Combination Chemotherapy With or Without Sodium Thiosulfate in Preventing Low Platelet Count While Treating Patients With Malignant Brain Tumors

Unknown
NCT00303849Phase 1

Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors

Completed
NCT00983398Phase 1

Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors

Unknown
NCT04251832Phase 2

Efficacy of Sodium Thiosulfate in Shoulder Pain in Calcific Tendinitis of the Rotator Cuff

Unknown
NCT00293475Phase 1

Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma

Unknown
NCT02899364Phase 2

Sodium Thiosulfate to Preserve Cardiac Function in STEMI

Unknown

Drug Details

Intervention Type
DRUG
Total Trials
38