Success Metrics

Clinical Success Rate
79.6%

Based on 199 completed trials

Completion Rate
80%(199/250)
Active Trials
77(20%)
Results Posted
69%(138 trials)
Terminated
51(13%)

Phase Distribution

Ph early_phase_1
9
2%
Ph not_applicable
20
5%
Ph phase_2
147
38%
Ph phase_1
127
33%
Ph phase_3
29
7%
Ph phase_4
48
12%

Phase Distribution

136

Early Stage

147

Mid Stage

77

Late Stage

Phase Distribution380 total trials
Early Phase 1First-in-human
9(2.4%)
Phase 1Safety & dosage
127(33.4%)
Phase 2Efficacy & side effects
147(38.7%)
Phase 3Large-scale testing
29(7.6%)
Phase 4Post-market surveillance
48(12.6%)
N/ANon-phased studies
20(5.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

74.0%

199 of 269 finished

Non-Completion Rate

26.0%

70 ended early

Currently Active

77

trials recruiting

Total Trials

390

all time

Status Distribution
Active(92)
Completed(199)
Terminated(70)
Other(29)

Detailed Status

Completed199
Terminated51
Recruiting42
Active, not recruiting35
unknown28
Withdrawn19

Development Timeline

Analytics

Development Status

Total Trials
390
Active
77
Success Rate
79.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 19 (2.4%)
Phase 1127 (33.4%)
Phase 2147 (38.7%)
Phase 329 (7.6%)
Phase 448 (12.6%)
N/A20 (5.3%)

Trials by Status

not_yet_recruiting123%
unknown287%
suspended10%
completed19951%
enrolling_by_invitation31%
recruiting4211%
terminated5113%
withdrawn195%
active_not_recruiting359%

Recent Activity

Clinical Trials (390)

Showing 20 of 390 trialsScroll for more
NCT05896839Phase 1

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

Recruiting
NCT06876142Phase 1

Combination Therapy (Mirdametinib and Sirolimus) for RAS Mutated Relapsed Refractory Multiple Myeloma

Suspended
NCT06261060Phase 2

Low-Dose Sirolimus to Increase Hematopoietic Function in Patients With RUNX1 Familial Platelet Disorder

Active Not Recruiting
NCT05436418Phase 1

The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation

Recruiting
NCT04959175Phase 1

Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies

Recruiting
NCT06325709Phase 1

Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease

Recruiting
NCT07015684Phase 1

131I-apamistamab-based Conditioning for Hematopoietic Stem Cell Transplant (HSCT) in Advanced Sickle Cell Disease (SCD)

Recruiting
NCT04177004Phase 1

Human Lysozyme Goat Milk for the Prevention of Graft Versus Host Disease in Patients With Blood Cancer Undergoing a Donor Stem Cell Transplant

Active Not Recruiting
NCT07113743Phase 1

Part B- G1X-CGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous Disease

Enrolling By Invitation
NCT07634120Phase 2

Vertebrobasilar Dolichoectasia Treatment With Sirolimus

Not Yet Recruiting
NCT00092222Phase 2

Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity

Active Not Recruiting
NCT07162038Phase 1

Phase I Trial Integrating HLA-Haploidentical Anti-CD19 CAR-T Cells With Post-Transplantation Cyclophosphamide-Based HLA-Haploidentical Hematopoietic Cell Transplantation

Recruiting
NCT05327023Phase 1

Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies

Recruiting
NCT03910452Early Phase 1

Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide

Active Not Recruiting
NCT06084780Phase 2

Intestinal & Multivisceral Transplantation for Unresectable Mucinous Carcinoma Peritonei (TRANSCAPE)

Not Yet Recruiting
NCT02629120Phase 1

High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease

Active Not Recruiting
NCT07581704Phase 1

Sirolimus Pre-conditioning on T Cell Activity and T-cell Engaging Bispecific Antibody Efficacy in Multiple Myeloma

Recruiting
NCT06872333Phase 2

Allo HSCT for High Risk Hemoglobinopathies

Recruiting
NCT05269849Phase 2

Sirolimus for Nosebleeds in HHT

Completed
NCT00544115Phase 2

Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
390