Success Metrics

Clinical Success Rate
100.0%

Based on 15 completed trials

Completion Rate
100%(15/15)
Active Trials
5(24%)
Results Posted
87%(13 trials)

Phase Distribution

Ph phase_3
8
38%
Ph phase_4
2
10%
Ph phase_2
9
43%
Ph phase_1
2
10%

Phase Distribution

2

Early Stage

9

Mid Stage

10

Late Stage

Phase Distribution21 total trials
Phase 1Safety & dosage
2(9.5%)
Phase 2Efficacy & side effects
9(42.9%)
Phase 3Large-scale testing
8(38.1%)
Phase 4Post-market surveillance
2(9.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

100.0%

15 of 15 finished

Non-Completion Rate

0.0%

0 ended early

Currently Active

5

trials recruiting

Total Trials

21

all time

Status Distribution
Active(6)
Completed(15)

Detailed Status

Completed15
Active, not recruiting3
Recruiting2
Enrolling by invitation1

Development Timeline

Analytics

Development Status

Total Trials
21
Active
5
Success Rate
100.0%
Most Advanced
Phase 4

Trials by Phase

Phase 12 (9.5%)
Phase 29 (42.9%)
Phase 38 (38.1%)
Phase 42 (9.5%)

Trials by Status

recruiting210%
completed1571%
active_not_recruiting314%
enrolling_by_invitation15%

Recent Activity

Clinical Trials (21)

Showing 20 of 21 trialsScroll for more
NCT07496463Phase 2

Setmelanotide to Treat Obesity in a Patient With Pseudohypoparathyroidism Type 1a (PHP1a)

Enrolling By Invitation
NCT06596135Phase 3

Open-Label Extension Study of Setmelanotide

Completed
NCT07674290Phase 4

Real-World Effects of MC4R Agonist Therapy in BBS and Severe Genetic Obesity

Recruiting
NCT05774756Phase 3

A Trial of Setmelanotide in Acquired Hypothalamic Obesity

Active Not Recruiting
NCT06760546Phase 3

A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

Recruiting
NCT06772597Phase 2

A Study of Setmelanotide in Patients With Prader-Willi Syndrome

Active Not Recruiting
NCT05093634Phase 3

EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

Active Not Recruiting
NCT04963231Phase 2

DAYBREAK: A Study of Setmelanotide in Participants With Specific Gene Variants in the Melanocortin-4 Receptor (MC4R) Pathway

Completed
NCT03651765Phase 2

Long Term Extension Trial of Setmelanotide

Completed
NCT04725240Phase 2

Open-Label Study of Setmelanotide in Hypothalamic Obesity

Completed
NCT04966741Phase 3

Setmelanotide in Pediatric Participants With Rare Genetic Diseases of Obesity

Completed
NCT05046132Phase 4

Study of Setmelanotide Effects on QTc (Corrected QT) Interval in Healthy Participants

Completed
NCT03746522Phase 3

Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Participants With Moderate to Severe Obesity

Completed
NCT02896192Phase 3

Setmelanotide for the Treatment of Early-Onset Pro-Opiomelanocortin (POMC) Deficiency Obesity

Completed
NCT03013543Phase 2

Setmelanotide Phase 2 Treatment Trial in Participants With Rare Genetic Disorders of Obesity

Completed
NCT01749137Phase 2

Phase 2 Study to Evaluate Safety and Efficacy of RM-493 in Obese Participants

Completed
NCT02041195Phase 1

Phase 1b/2a Study to Evaluate Safety and Efficacy of Setmelanotide in Obese Patients

Completed
NCT02311673Phase 2

Phase 2 Trial to Evaluate Safety and Efficacy of Setmelanotide (RM-493) in Obese Participants With Prader-Willi Syndrome

Completed
NCT03287960Phase 3

Setmelanotide for the Treatment of Leptin Receptor (LEPR) Deficiency Obesity

Completed
NCT03262610Phase 2

Setmelanotide in a Single Patient With Partial Lipodystrophy

Completed

Drug Details

Intervention Type
DRUG
Total Trials
21