Success Metrics

Clinical Success Rate
100.0%

Based on 14 completed trials

Completion Rate
100%(14/14)
Active Trials
4(20%)
Results Posted
86%(12 trials)

Phase Distribution

Ph phase_1
2
10%
Ph phase_2
9
45%
Ph phase_3
8
40%
Ph phase_4
1
5%

Phase Distribution

2

Early Stage

9

Mid Stage

9

Late Stage

Phase Distribution20 total trials
Phase 1Safety & dosage
2(10.0%)
Phase 2Efficacy & side effects
9(45.0%)
Phase 3Large-scale testing
8(40.0%)
Phase 4Post-market surveillance
1(5.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

100.0%

14 of 14 finished

Non-Completion Rate

0.0%

0 ended early

Currently Active

4

trials recruiting

Total Trials

20

all time

Status Distribution
Active(6)
Completed(14)

Detailed Status

Completed14
Active, not recruiting3
Recruiting1
Enrolling by invitation1
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
20
Active
4
Success Rate
100.0%
Most Advanced
Phase 4

Trials by Phase

Phase 12 (10.0%)
Phase 29 (45.0%)
Phase 38 (40.0%)
Phase 41 (5.0%)

Trials by Status

recruiting15%
completed1470%
enrolling_by_invitation15%
not_yet_recruiting15%
active_not_recruiting315%

Recent Activity

Clinical Trials (20)

Showing 20 of 20 trials
NCT07496463Phase 2

Setmelanotide to Treat Obesity in a Patient With Pseudohypoparathyroidism Type 1a (PHP1a)

Not Yet Recruiting
NCT06772597Phase 2

A Study of Setmelanotide in Patients With Prader-Willi Syndrome

Active Not Recruiting
NCT06760546Phase 3

A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

Recruiting
NCT05093634Phase 3

EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

Active Not Recruiting
NCT06596135Phase 3

Open-Label Extension Study of Setmelanotide

Enrolling By Invitation
NCT05774756Phase 3

A Trial of Setmelanotide in Acquired Hypothalamic Obesity

Active Not Recruiting
NCT04963231Phase 2

DAYBREAK: A Study of Setmelanotide in Participants With Specific Gene Variants in the Melanocortin-4 Receptor (MC4R) Pathway

Completed
NCT03651765Phase 2

Long Term Extension Trial of Setmelanotide

Completed
NCT04725240Phase 2

Open-Label Study of Setmelanotide in Hypothalamic Obesity

Completed
NCT04966741Phase 3

Setmelanotide in Pediatric Participants With Rare Genetic Diseases of Obesity

Completed
NCT05046132Phase 4

Study of Setmelanotide Effects on QTc (Corrected QT) Interval in Healthy Participants

Completed
NCT03746522Phase 3

Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Participants With Moderate to Severe Obesity

Completed
NCT02896192Phase 3

Setmelanotide for the Treatment of Early-Onset Pro-Opiomelanocortin (POMC) Deficiency Obesity

Completed
NCT03013543Phase 2

Setmelanotide Phase 2 Treatment Trial in Participants With Rare Genetic Disorders of Obesity

Completed
NCT01749137Phase 2

Phase 2 Study to Evaluate Safety and Efficacy of RM-493 in Obese Participants

Completed
NCT02041195Phase 1

Phase 1b/2a Study to Evaluate Safety and Efficacy of Setmelanotide in Obese Patients

Completed
NCT02311673Phase 2

Phase 2 Trial to Evaluate Safety and Efficacy of Setmelanotide (RM-493) in Obese Participants With Prader-Willi Syndrome

Completed
NCT03287960Phase 3

Setmelanotide for the Treatment of Leptin Receptor (LEPR) Deficiency Obesity

Completed
NCT03262610Phase 2

Setmelanotide in a Single Patient With Partial Lipodystrophy

Completed
NCT04348175Phase 1

A Phase 1 Study to Evaluate the Pharmacokinetics of Setmelanotide in Subjects With Varying Degrees of Renal Impairment

Completed

All 20 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
20