Success Metrics

Clinical Success Rate
80.0%

Based on 8 completed trials

Completion Rate
80%(8/10)
Active Trials
3(20%)
Results Posted
50%(4 trials)
Terminated
2(13%)

Phase Distribution

Ph phase_3
2
13%
Ph not_applicable
3
20%
Ph phase_1
1
7%
Ph phase_2
5
33%
Ph phase_4
4
27%

Phase Distribution

1

Early Stage

5

Mid Stage

6

Late Stage

Phase Distribution15 total trials
Phase 1Safety & dosage
1(6.7%)
Phase 2Efficacy & side effects
5(33.3%)
Phase 3Large-scale testing
2(13.3%)
Phase 4Post-market surveillance
4(26.7%)
N/ANon-phased studies
3(20.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

80.0%

8 of 10 finished

Non-Completion Rate

20.0%

2 ended early

Currently Active

3

trials recruiting

Total Trials

15

all time

Status Distribution
Active(3)
Completed(8)
Terminated(2)
Other(2)

Detailed Status

Completed8
Recruiting3
Terminated2
unknown2

Development Timeline

Analytics

Development Status

Total Trials
15
Active
3
Success Rate
80.0%
Most Advanced
Phase 4

Trials by Phase

Phase 11 (6.7%)
Phase 25 (33.3%)
Phase 32 (13.3%)
Phase 44 (26.7%)
N/A3 (20.0%)

Trials by Status

recruiting320%
completed853%
terminated213%
unknown213%

Recent Activity

3 active trials
Showing 5 of 15
recruitingphase_3

Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

NCT05140525
terminatedphase_4

Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH

NCT04954742
recruitingphase_3

Riociguat-Discontinue Effects on Right HEART in CTEPH (RED-HEART)

NCT06922240
completedphase_1

A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants

NCT04211272
recruitingphase_4

Pulmonary Hypertension: Intensification and Personalisation of Combination Rx

NCT05825417
View all 15 trials

Clinical Trials (15)

Showing 15 of 15 trials
NCT05140525Phase 3

Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

Recruiting
NCT04954742Phase 4

Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH

Terminated
NCT06922240Phase 3

Riociguat-Discontinue Effects on Right HEART in CTEPH (RED-HEART)

Recruiting
NCT04211272Phase 1

A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants

Completed
NCT05825417Phase 4

Pulmonary Hypertension: Intensification and Personalisation of Combination Rx

Recruiting
NCT05582811Not Applicable

Effect of Riocigaut on Cerebral Vasodilation and Headache Induction in Healthy Volunteers

Completed
NCT05762146Phase 2

Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE

Unknown
NCT02633397Phase 2

A Multi-Center Study of Riociguat in Patients With Sickle Cell Diseases

Completed
NCT03074539Not Applicable

Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension

Completed
NCT03273257Phase 2

Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study)

Terminated
NCT02634203Not Applicable

Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary Hypertension

Completed
NCT02744339Phase 2

Pharmacodynamic Effects of Riociguat in Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction

Completed
NCT02915835Phase 2

Riociguat in Scleroderma Associated Digital Ulcers

Completed
NCT02024386Phase 4

Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude

Completed
NCT02625558Phase 4

Riociguat for Sarcoidosis Associated Pulmonary Hypertension

Unknown

All 15 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
15