Success Metrics

Clinical Success Rate
80.0%

Based on 8 completed trials

Completion Rate
80%(8/10)
Active Trials
3(20%)
Results Posted
63%(5 trials)
Terminated
2(13%)

Phase Distribution

Ph phase_1
1
7%
Ph not_applicable
3
20%
Ph phase_3
2
13%
Ph phase_2
5
33%
Ph phase_4
4
27%

Phase Distribution

1

Early Stage

5

Mid Stage

6

Late Stage

Phase Distribution15 total trials
Phase 1Safety & dosage
1(6.7%)
Phase 2Efficacy & side effects
5(33.3%)
Phase 3Large-scale testing
2(13.3%)
Phase 4Post-market surveillance
4(26.7%)
N/ANon-phased studies
3(20.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

80.0%

8 of 10 finished

Non-Completion Rate

20.0%

2 ended early

Currently Active

3

trials recruiting

Total Trials

15

all time

Status Distribution
Active(3)
Completed(8)
Terminated(2)
Other(2)

Detailed Status

Completed8
unknown2
Terminated2
Recruiting2
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
15
Active
3
Success Rate
80.0%
Most Advanced
Phase 4

Trials by Phase

Phase 11 (6.7%)
Phase 25 (33.3%)
Phase 32 (13.3%)
Phase 44 (26.7%)
N/A3 (20.0%)

Trials by Status

unknown213%
terminated213%
active_not_recruiting17%
recruiting213%
completed853%

Recent Activity

3 active trials
Showing 5 of 15
active_not_recruitingphase_4

Pulmonary Hypertension: Intensification and Personalisation of Combination Rx

NCT05825417
terminatedphase_4

Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH

NCT04954742
recruitingphase_3

Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

NCT05140525
recruitingphase_3

Riociguat-Discontinue Effects on Right HEART in CTEPH (RED-HEART)

NCT06922240
completedphase_1

A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants

NCT04211272
View all 15 trials

Clinical Trials (15)

Showing 15 of 15 trials
NCT05825417Phase 4

Pulmonary Hypertension: Intensification and Personalisation of Combination Rx

Active Not Recruiting
NCT04954742Phase 4

Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH

Terminated
NCT05140525Phase 3

Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

Recruiting
NCT06922240Phase 3

Riociguat-Discontinue Effects on Right HEART in CTEPH (RED-HEART)

Recruiting
NCT04211272Phase 1

A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants

Completed
NCT05582811Not Applicable

Effect of Riocigaut on Cerebral Vasodilation and Headache Induction in Healthy Volunteers

Completed
NCT05762146Phase 2

Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE

Unknown
NCT02633397Phase 2

A Multi-Center Study of Riociguat in Patients With Sickle Cell Diseases

Completed
NCT03074539Not Applicable

Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension

Completed
NCT03273257Phase 2

Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study)

Terminated
NCT02634203Not Applicable

Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary Hypertension

Completed
NCT02744339Phase 2

Pharmacodynamic Effects of Riociguat in Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction

Completed
NCT02915835Phase 2

Riociguat in Scleroderma Associated Digital Ulcers

Completed
NCT02024386Phase 4

Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude

Completed
NCT02625558Phase 4

Riociguat for Sarcoidosis Associated Pulmonary Hypertension

Unknown

All 15 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
15