Success Metrics

Clinical Success Rate
65.5%

Based on 36 completed trials

Completion Rate
65%(36/55)
Active Trials
63(50%)
Results Posted
78%(28 trials)
Terminated
19(15%)

Phase Distribution

Ph phase_2
32
25%
Ph phase_3
22
17%
Ph phase_4
5
4%
Ph early_phase_1
3
2%
Ph not_applicable
1
1%
Ph phase_1
48
38%

Phase Distribution

51

Early Stage

32

Mid Stage

27

Late Stage

Phase Distribution111 total trials
Early Phase 1First-in-human
3(2.7%)
Phase 1Safety & dosage
48(43.2%)
Phase 2Efficacy & side effects
32(28.8%)
Phase 3Large-scale testing
22(19.8%)
Phase 4Post-market surveillance
5(4.5%)
N/ANon-phased studies
1(0.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

63.2%

36 of 57 finished

Non-Completion Rate

36.8%

21 ended early

Currently Active

63

trials recruiting

Total Trials

126

all time

Status Distribution
Active(63)
Completed(36)
Terminated(21)
Other(6)

Detailed Status

Completed36
Recruiting33
Active, not recruiting30
Terminated19
unknown6
Withdrawn2

Development Timeline

Analytics

Development Status

Total Trials
126
Active
63
Success Rate
65.5%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.7%)
Phase 148 (43.2%)
Phase 232 (28.8%)
Phase 322 (19.8%)
Phase 45 (4.5%)
N/A1 (0.9%)

Trials by Status

terminated1915%
completed3629%
active_not_recruiting3024%
recruiting3326%
unknown65%
withdrawn22%

Recent Activity

Clinical Trials (126)

Showing 20 of 126 trialsScroll for more
NCT05827081Phase 3

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

Recruiting
NCT05203172Phase 4

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

Recruiting
NCT05161195Phase 4

Roll-over Study to Allow Continued Access to Ribociclib

Active Not Recruiting
NCT06625775Phase 1

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

Recruiting
NCT07492641Phase 3

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

Recruiting
NCT05867251Phase 1

Study of AVZO-021 in Patients With Advanced Solid Tumors

Recruiting
NCT07054190Phase 2

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

Recruiting
NCT06377852Phase 3

The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

Recruiting
NCT05384119Phase 1

Phase 1b/2 Study of TTI-101 in Combination for Patients With Metastatic Hormone Receptor-Positive and HER2-Negative Breast Cancer

Terminated
NCT04964934Phase 3

Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)

Active Not Recruiting
NCT07085767Phase 3

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

Recruiting
NCT07174336Phase 3

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Recruiting
NCT03701334Phase 3

A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer

Active Not Recruiting
NCT05508906Phase 1

Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

Active Not Recruiting
NCT06065748Phase 3

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Active Not Recruiting
NCT05870579Phase 1

[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer

Active Not Recruiting
NCT07647328Phase 3

A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer

Recruiting
NCT07405801Phase 2

A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

Recruiting
NCT04315233Phase 1

Ribociclib&Belinostat In Patients w Metastatic Triple Neg Breast Cancer & Recurrent Ovarian Cancer w Response Prediction By Genomics

Terminated
NCT04802759Phase 1

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
126