Success Metrics

Clinical Success Rate
66.0%

Based on 35 completed trials

Completion Rate
66%(35/53)
Active Trials
63(51%)
Results Posted
74%(26 trials)
Terminated
18(15%)

Phase Distribution

Ph phase_1
48
39%
Ph phase_4
4
3%
Ph early_phase_1
3
2%
Ph phase_2
31
25%
Ph not_applicable
1
1%
Ph phase_3
22
18%

Phase Distribution

51

Early Stage

31

Mid Stage

26

Late Stage

Phase Distribution109 total trials
Early Phase 1First-in-human
3(2.8%)
Phase 1Safety & dosage
48(44.0%)
Phase 2Efficacy & side effects
31(28.4%)
Phase 3Large-scale testing
22(20.2%)
Phase 4Post-market surveillance
4(3.7%)
N/ANon-phased studies
1(0.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

63.6%

35 of 55 finished

Non-Completion Rate

36.4%

20 ended early

Currently Active

63

trials recruiting

Total Trials

124

all time

Status Distribution
Active(63)
Completed(35)
Terminated(20)
Other(6)

Detailed Status

Recruiting36
Completed35
Active, not recruiting27
Terminated18
unknown6
Withdrawn2

Development Timeline

Analytics

Development Status

Total Trials
124
Active
63
Success Rate
66.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.8%)
Phase 148 (44.0%)
Phase 231 (28.4%)
Phase 322 (20.2%)
Phase 44 (3.7%)
N/A1 (0.9%)

Trials by Status

withdrawn22%
terminated1815%
recruiting3629%
active_not_recruiting2722%
completed3528%
unknown65%

Recent Activity

Clinical Trials (124)

Showing 20 of 124 trialsScroll for more
NCT07174336Phase 3

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Recruiting
NCT06380751Phase 3

Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

Recruiting
NCT06075758

A Study of Ribociclib in Combination With Hormonal Therapy in HR+/HER2- Advanced or Metastatic Breast Cancer

Completed
NCT07492641Phase 3

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

Recruiting
NCT05238922Phase 1

Study of INCB123667 in Subjects With Advanced Solid Tumors

Active Not Recruiting
NCT07085767Phase 3

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

Recruiting
NCT05827081Phase 3

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

Recruiting
NCT07054190Phase 2

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

Recruiting
NCT05467891Phase 2

Ribociclib And Endocrine Treatment of Physician's Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer

Recruiting
NCT05996107Phase 1

Study of Ribociclib Administered Concurrently With Postoperative Radiation Therapy in Patients With High-Risk, HR+/HER2- Breast Cancer

Recruiting
NCT04964934Phase 3

Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)

Active Not Recruiting
NCT07405801Phase 2

A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

Recruiting
NCT06726148Phase 1

Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and in Patients With Other Advanced Solid Tumors

Recruiting
NCT07647328Phase 3

A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer

Recruiting
NCT02813135Phase 1

European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors

Recruiting
NCT03439046Phase 3

Study of the Molecular Features of Postmenopausal Women With HR+ HER2-negative aBC on First-line Treatment With Ribociclib and Letrozole and, in Patients With a PIK3CA Mutation, on Second-line Treatment With Alpelisib Plus Fulvestrant

Terminated
NCT03671330Phase 2

Efficacy and Safety of Ribociclib in Pre- and Postmenopausal Chinese Women With HR Positive, HER2-negative, Advanced Breast Cancer.

Completed
NCT04116541Phase 2

A Study Evaluating the Activity of Anti-cancer Treatments Targeting Tumor Molecular Alterations/Characteristics in Advanced / Metastatic Tumors.

Recruiting
NCT05768139Phase 1

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

Recruiting
NCT06239467Phase 1

First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
124