Success Metrics

Clinical Success Rate
67.9%

Based on 36 completed trials

Completion Rate
68%(36/53)
Active Trials
60(49%)
Results Posted
67%(24 trials)
Terminated
17(14%)

Phase Distribution

Ph phase_4
4
3%
Ph early_phase_1
3
2%
Ph phase_1
48
39%
Ph phase_2
31
25%
Ph not_applicable
1
1%
Ph phase_3
21
17%

Phase Distribution

51

Early Stage

31

Mid Stage

25

Late Stage

Phase Distribution108 total trials
Early Phase 1First-in-human
3(2.8%)
Phase 1Safety & dosage
48(44.4%)
Phase 2Efficacy & side effects
31(28.7%)
Phase 3Large-scale testing
21(19.4%)
Phase 4Post-market surveillance
4(3.7%)
N/ANon-phased studies
1(0.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

65.5%

36 of 55 finished

Non-Completion Rate

34.5%

19 ended early

Currently Active

60

trials recruiting

Total Trials

123

all time

Status Distribution
Active(62)
Completed(36)
Terminated(19)
Other(6)

Detailed Status

Recruiting39
Completed36
Active, not recruiting21
Terminated17
unknown6
Withdrawn2

Development Timeline

Analytics

Development Status

Total Trials
123
Active
60
Success Rate
67.9%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.8%)
Phase 148 (44.4%)
Phase 231 (28.7%)
Phase 321 (19.4%)
Phase 44 (3.7%)
N/A1 (0.9%)

Trials by Status

terminated1714%
active_not_recruiting2117%
unknown65%
recruiting3932%
withdrawn22%
completed3629%
not_yet_recruiting22%

Recent Activity

Clinical Trials (123)

Showing 20 of 123 trialsScroll for more
NCT06075758

A Study of Ribociclib in Combination With Hormonal Therapy in HR+/HER2- Advanced or Metastatic Breast Cancer

Completed
NCT06065748Phase 3

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Recruiting
NCT06905301

Implementation Study to Describe and Compare Retention Rate and Adherence to Adjuvant Therapy With Ribociclib With and Without Usage of Mobile Application in Patients With HR+ HER2-negative Stage II and III Breast Cancer in Real-world Practice

Recruiting
NCT05827081Phase 3

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

Recruiting
NCT05870579Phase 1

[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer

Recruiting
NCT07174336Phase 3

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Recruiting
NCT06726148Phase 1

Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

Recruiting
NCT07054190Phase 2

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

Recruiting
NCT07492641Phase 3

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

Not Yet Recruiting
NCT04116541Phase 2

A Study Evaluating the Activity of Anti-cancer Treatments Targeting Tumor Molecular Alterations/Characteristics in Advanced / Metastatic Tumors.

Recruiting
NCT05768139Phase 1

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

Recruiting
NCT05843253Phase 2

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Recruiting
NCT05683418Phase 1

A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer

Recruiting
NCT02555189Phase 1

Enzalutamide With Ribociclib in Treating Patients With Metastatic Castrate-Resistant, Chemotherapy Naive Prostate Cancer That Retains Retinoblastoma Expression

Terminated
NCT04964934Phase 3

Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)

Active Not Recruiting
NCT06930859

Non-interventional Study to Assess the Effectiveness and Safety of Ribociclib in the Adjuvant Therapy of Hormone Receptor Positive (HR+) HER2-negative Stage II and III Breast Cancer in Real Clinical Practice in Russia

Recruiting
NCT07405801Phase 2

A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

Recruiting
NCT04862663Phase 3

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

Recruiting
NCT07085767Phase 3

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

Recruiting
NCT06380751Phase 3

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

Recruiting

Drug Details

Intervention Type
OTHER
Total Trials
123