Success Metrics

Clinical Success Rate
81.3%

Based on 13 completed trials

Completion Rate
81%(13/16)
Active Trials
10(32%)
Results Posted
85%(11 trials)
Terminated
3(10%)

Phase Distribution

Ph phase_3
5
16%
Ph early_phase_1
1
3%
Ph phase_1
19
61%
Ph phase_2
5
16%

Phase Distribution

20

Early Stage

5

Mid Stage

5

Late Stage

Phase Distribution30 total trials
Early Phase 1First-in-human
1(3.3%)
Phase 1Safety & dosage
19(63.3%)
Phase 2Efficacy & side effects
5(16.7%)
Phase 3Large-scale testing
5(16.7%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

76.5%

13 of 17 finished

Non-Completion Rate

23.5%

4 ended early

Currently Active

10

trials recruiting

Total Trials

31

all time

Status Distribution
Active(11)
Completed(13)
Terminated(4)
Other(3)

Detailed Status

Completed13
Recruiting8
Terminated3
unknown3
Active, not recruiting2
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
31
Active
10
Success Rate
81.3%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (3.3%)
Phase 119 (63.3%)
Phase 25 (16.7%)
Phase 35 (16.7%)

Trials by Status

completed1342%
terminated310%
withdrawn13%
active_not_recruiting26%
unknown310%
recruiting826%
not_yet_recruiting13%

Recent Activity

Clinical Trials (31)

Showing 20 of 31 trialsScroll for more
NCT04493138Phase 1

Azacitidine and Quizartinib for the Treatment of Myelodysplastic Syndrome or Myelodysplastic/Myeloproliferative Neoplasm With FLT3 or CBL Mutations

Active Not Recruiting
NCT06578247Phase 3

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

Recruiting
NCT04128748Phase 1

Liposomal Cytarabine and Daunorubicin (CPX-351) and Quizartinib for the Treatment of Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome

Recruiting
NCT06740799Phase 1

Assessment of Quizartinib Pharmacokinetic in Subjects With Severe Hepatic Impairment

Recruiting
NCT03793478Phase 1

Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood

Active Not Recruiting
NCT04107727Phase 2

Trial to Compare Efficacy and Safety of Chemotherapy/Quizartinib vs Chemotherapy/Placebo in Adults FMS-like Tyrosine Kinase 3 (FLT3) Wild-type Acute Myeloid Leukemia (AML)

Completed
NCT07478991Phase 3

Azacytidine, Venetoclax Plus Minus Quizartinib for First Line Older/Unfit AML Patients (VENP-A-QUI)

Not Yet Recruiting
NCT05735184Phase 1

A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Recruiting
NCT06769490Phase 1

Dose Escalation and Expansion of Ziftomenib in Combination With Quizartinib in Acute Myeloid Leukemia

Recruiting
NCT03661307Phase 1

Quizartinib, Decitabine, and Venetoclax in Treating Participants With Untreated or Relapsed Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

Recruiting
NCT04047641Phase 1

Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Recruiting
NCT06262438Phase 2

CHIP-AML22/Quizartinib: Quizartinib + Chemotherapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML Patients

Recruiting
NCT06772246Phase 1

A Study to Evaluate QTc Prolongation With Quizartinib in Healthy Subjects Under Rapid Acceleration of Heart Rate

Completed
NCT01892371Phase 1

Quizartinib With Azacitidine or Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Completed
NCT02834390Phase 1

Study of Quizartinib in Japanese Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)

Completed
NCT06740825Phase 1

Study to Assess the Effect of a CYP3A Weak Inducer Rufinamide on Quizartinib Pharmacokinetics in Healthy Subjects

Completed
NCT03735875Phase 1

Venetoclax and Quizartinib in Treating Patients With FLT3-mutated Recurrent or Refractory Acute Myeloid Leukemia

Terminated
NCT02668653Phase 3

Quizartinib With Standard of Care Chemotherapy and as Continuation Therapy in Patients With Newly Diagnosed FLT3-ITD (+) Acute Myeloid Leukemia (AML)

Completed
NCT04209725Phase 2

A Study of CPX-351 (Vyxeos™) With Quizartinib for the Treatment of FLT3-ITD Mutation-Positive Acute Myeloid Leukemia

Terminated
NCT04473664Phase 1

A Study of Quizartinib Pharmacokinetics in Participants With Moderate Hepatic Impairment

Completed

Drug Details

Intervention Type
DRUG
Total Trials
31