Success Metrics

Clinical Success Rate
85.7%

Based on 6 completed trials

Completion Rate
86%(6/7)
Active Trials
7(41%)
Results Posted
67%(4 trials)
Terminated
1(6%)

Phase Distribution

Ph phase_2
3
18%
Ph phase_4
1
6%
Ph phase_1
4
24%
Ph phase_3
6
35%

Phase Distribution

4

Early Stage

3

Mid Stage

7

Late Stage

Phase Distribution14 total trials
Phase 1Safety & dosage
4(28.6%)
Phase 2Efficacy & side effects
3(21.4%)
Phase 3Large-scale testing
6(42.9%)
Phase 4Post-market surveillance
1(7.1%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

85.7%

6 of 7 finished

Non-Completion Rate

14.3%

1 ended early

Currently Active

7

trials recruiting

Total Trials

17

all time

Status Distribution
Active(7)
Completed(6)
Terminated(1)
Other(3)

Detailed Status

Completed6
Recruiting5
unknown3
Active, not recruiting2
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
17
Active
7
Success Rate
85.7%
Most Advanced
Phase 4

Trials by Phase

Phase 14 (28.6%)
Phase 23 (21.4%)
Phase 36 (42.9%)
Phase 41 (7.1%)

Trials by Status

active_not_recruiting212%
completed635%
terminated16%
unknown318%
recruiting529%

Recent Activity

Clinical Trials (17)

Showing 17 of 17 trials
NCT06541704Phase 3

A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

Recruiting
NCT05133531Phase 3

A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment

Active Not Recruiting
NCT07154745Phase 3

A Study to Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working Efficiently

Recruiting
NCT07230834Phase 1

Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants

Recruiting
NCT07142343Phase 4

A Study to Test the Safety of Pozelimab in Pediatric Participants 1 to 5 Years of Age With a Rare Disease Called CHAPLE (Complement Hyperactivation, Angiopathic Thrombosis, Protein-losing Enteropathy) Disease

Recruiting
NCT05744921Phase 3

A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works

Recruiting
NCT05070858Phase 3

A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis

Active Not Recruiting
NCT05232110

Compassionate Use of Pozelimab

Unknown
NCT06003881

Compassionate Use of Pozelimab in Patients With CD55-Deficient Protein-Losing Enteropathy

Unknown
NCT06028594

Compassionate Use of Pozelimab and Cemdisiran Combination Therapy in Patients With Paroxysmal Nocturnal Hemoglobinuria

Unknown
NCT04209634Phase 2

Open-Label Efficacy and Safety Study of Pozelimab in Patients With CD55-Deficient Protein-Losing Enteropathy (CHAPLE Disease)

Completed
NCT04888507Phase 2

Pozelimab and Cemdisiran Combination Therapy in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Switch From Eculizumab Therapy

Completed
NCT05131204Phase 3

Efficacy and Safety of the Combination of Pozelimab and Cemdisiran Versus Continued Eculizumab or Ravulizumab Treatment in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria

Terminated
NCT04811716Phase 2

Pozelimab and Cemdisiran Combination Treatment in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Received Pozelimab Monotherapy

Completed
NCT04940364Phase 1

A Study to Examine the Safety, Tolerability and Biological Effects of Single Doses of Subcutaneously and Intravenously Administered Pozelimab as Monotherapy and in Combination With Single Doses of Subcutaneously Administered Cemdisiran in Adult Japanese Healthy Volunteers

Completed
NCT04601844Phase 1

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pozelimab in Combination With Cemdisiran in Healthy Adult Volunteers

Completed
NCT04491838Phase 1

Study of a Single Subcutaneous Dose of Pozelimab Produced From Two Different Manufacturing Processes in Healthy Adult Participants

Completed

All 17 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
17