Success Metrics

Clinical Success Rate
81.7%

Based on 76 completed trials

Completion Rate
82%(76/93)
Active Trials
83(40%)
Results Posted
95%(72 trials)
Terminated
17(8%)

Phase Distribution

Ph phase_4
5
2%
Ph phase_1
35
17%
Ph early_phase_1
2
1%
Ph not_applicable
3
1%
Ph phase_3
46
22%
Ph phase_2
108
52%

Phase Distribution

37

Early Stage

108

Mid Stage

51

Late Stage

Phase Distribution199 total trials
Early Phase 1First-in-human
2(1.0%)
Phase 1Safety & dosage
35(17.6%)
Phase 2Efficacy & side effects
108(54.3%)
Phase 3Large-scale testing
46(23.1%)
Phase 4Post-market surveillance
5(2.5%)
N/ANon-phased studies
3(1.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

78.4%

76 of 97 finished

Non-Completion Rate

21.6%

21 ended early

Currently Active

83

trials recruiting

Total Trials

206

all time

Status Distribution
Active(97)
Completed(76)
Terminated(21)
Other(12)

Detailed Status

Completed76
Active, not recruiting45
Recruiting38
Terminated17
Not yet recruiting14
unknown12

Development Timeline

Analytics

Development Status

Total Trials
206
Active
83
Success Rate
81.7%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (1.0%)
Phase 135 (17.6%)
Phase 2108 (54.3%)
Phase 346 (23.1%)
Phase 45 (2.5%)
N/A3 (1.5%)

Trials by Status

not_yet_recruiting147%
withdrawn42%
active_not_recruiting4522%
recruiting3818%
completed7637%
terminated178%
unknown126%

Recent Activity

Clinical Trials (206)

Showing 20 of 206 trialsScroll for more
NCT04208178Phase 3

Study of Alpelisib (BYL719) in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy in Patients With HER2-positive Advanced Breast Cancer With a PIK3CA Mutation

Active Not Recruiting
NCT03006172Phase 1

To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

Active Not Recruiting
NCT05113251Phase 3

Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer

Active Not Recruiting
NCT06876714Phase 3

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

Recruiting
NCT07518173Phase 3

A Study of BL-M07D1 Combined With Pertuzumab Versus Docetaxel Plus Trastuzumab and Pertuzumab in Patients With First-line HER2-positive Recurrent or Metastatic Breast Cancer

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT03199885Phase 3

Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer

Terminated
NCT06136897Phase 2

Testing Trastuzumab and Pertuzumab in Patients With Higher Than Normal Copies of the HER2 Gene Found in Their Tumors (MATCH - Subprotocol J)

Active Not Recruiting
NCT07610720Phase 2

Dalpiciclib, Anti-HER2 Therapy, and Endocrine Therapy for Hormone-Receptor-Positive, HER2-Positive Metastatic Breast Cancer

Recruiting
NCT07612215Phase 1

Elacestrant in Advanced Triple Positive Breast Cancer

Recruiting
NCT05582499Phase 2

Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy

Recruiting
NCT07578116Phase 3

Adding Surgery and Radiation to the Usual Treatment for HER2-Positive Breast Cancer That Had Already Spread at Diagnosis

Not Yet Recruiting
NCT04588545Phase 1

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

Active Not Recruiting
NCT03125928Phase 2

Clinical Trial of Atezolizumab With Paclitaxel, Trastuzumab, and Pertuzumab in Patients With Metastatic HER-2 Positive Breast Cancer

Active Not Recruiting
NCT06686394Phase 1

Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

Recruiting
NCT04784715Phase 3

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Active Not Recruiting
NCT04329065Phase 2

Concurrent WOKVAC Vaccination, Chemotherapy, and HER2-Targeted Monoclonal Antibody Therapy Before Surgery for the Treatment of Patients With Breast Cancer

Recruiting
NCT06445400Phase 2

A Study of BL-M07D1, BL-M07D1+Pertuzumab and BL-M07D1+Pertuzumab+Docetaxel in Patients With Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer

Active Not Recruiting
NCT02320435Phase 3

A Safety and Efficacy Extension Study of Pertuzumab in Patients With Solid Tumors Previously Enrolled in a Hoffmann-La Roche-Sponsored Pertuzumab Clinical Trial

Active Not Recruiting
NCT05319873Phase 1

Ribociclib, Tucatinib, and Trastuzumab for the Treatment of HER2 Positive Breast Cancer

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
206