Success Metrics

Clinical Success Rate
81.9%

Based on 77 completed trials

Completion Rate
82%(77/94)
Active Trials
82(39%)
Results Posted
95%(73 trials)
Terminated
17(8%)

Phase Distribution

Ph early_phase_1
2
1%
Ph phase_2
110
53%
Ph phase_4
5
2%
Ph not_applicable
3
1%
Ph phase_1
35
17%
Ph phase_3
47
22%

Phase Distribution

37

Early Stage

110

Mid Stage

52

Late Stage

Phase Distribution202 total trials
Early Phase 1First-in-human
2(1.0%)
Phase 1Safety & dosage
35(17.3%)
Phase 2Efficacy & side effects
110(54.5%)
Phase 3Large-scale testing
47(23.3%)
Phase 4Post-market surveillance
5(2.5%)
N/ANon-phased studies
3(1.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

78.6%

77 of 98 finished

Non-Completion Rate

21.4%

21 ended early

Currently Active

82

trials recruiting

Total Trials

209

all time

Status Distribution
Active(99)
Completed(77)
Terminated(21)
Other(12)

Detailed Status

Completed77
Active, not recruiting44
Recruiting38
Terminated17
Not yet recruiting17
unknown12

Development Timeline

Analytics

Development Status

Total Trials
209
Active
82
Success Rate
81.9%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (1.0%)
Phase 135 (17.3%)
Phase 2110 (54.5%)
Phase 347 (23.3%)
Phase 45 (2.5%)
N/A3 (1.5%)

Trials by Status

unknown126%
recruiting3818%
terminated178%
withdrawn42%
active_not_recruiting4421%
completed7737%
not_yet_recruiting178%

Recent Activity

Clinical Trials (209)

Showing 20 of 209 trialsScroll for more
NCT06439693Phase 2

The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

Recruiting
NCT06876714Phase 3

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT06136897Phase 2

Testing Trastuzumab and Pertuzumab in Patients With Higher Than Normal Copies of the HER2 Gene Found in Their Tumors (MATCH - Subprotocol J)

Active Not Recruiting
NCT04784715Phase 3

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Active Not Recruiting
NCT06445400Phase 2

A Study of BL-M07D1, BL-M07D1+Pertuzumab and BL-M07D1+Pertuzumab+Docetaxel in Patients With Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer

Active Not Recruiting
NCT03304080Phase 1

Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HR-positive, HER2-positive Metastatic Breast

Active Not Recruiting
NCT02252887Phase 2

Gemcitabine, Trastuzumab, and Pertuzumab in the Treatment of Metastatic HER2-Positive Breast Cancer After Prior Trastuzumab/Pertuzumab, or Pertuzumab Based Therapy

Completed
NCT07683754Phase 3

T-DXd Based Therapy Followed by Endocrine Therapy Plus Dual HER2 Blockade in First-line HER2+/ HR+ Metastatic Breast Cancer and Retreatment With T-DXd

Not Yet Recruiting
NCT05132582Phase 3

A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer

Active Not Recruiting
NCT07716046Phase 2

Fulvestaciclib Combined With Anti-HER2 and Endocrine Therapy for HR+/HER2+ Advanced Breast Cancer

Not Yet Recruiting
NCT04158258

A Study to Describe the Diagnosis, Anti-Cancer Treatment and Clinical Outcome in Patients With Newly Diagnosed Breast Cancer in Latin America

Active Not Recruiting
NCT07102381Phase 2

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

Recruiting
NCT04266249Phase 2

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

Active Not Recruiting
NCT03747120Phase 2

Neoadjuvant Her2-targeted Therapy and Immunotherapy With Pembrolizumab [IIT2018-04-MCARTHUR-NEOHP]

Active Not Recruiting
NCT06747338Phase 3

A Phase III Study of KN026 in Combination With HB1801 ± Carboplatin as Neoadjuvant Treatment for Early or Locally Advanced HER2-Positive Breast Cancer

Active Not Recruiting
NCT01937117Phase 2

Pertuzumab and Trastuzumab as Neoadjuvant Treatment in Patients With HER2-Positive Breast Cancer

Active Not Recruiting
NCT07679269Phase 2

Roll-Over Study of Alpelisib (BYL719) for Continued Access and Long-Term Safety.

Not Yet Recruiting
NCT07407920Phase 2

Ph2 Study for Optimization of Adjunct Systemic Therapy in HER2+ Patients, MolecularPCR Trial

Recruiting
NCT05323955Phase 2

Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients With aDvanced Human Epidermal Growth Factor Receptor 2+ brEast Cancer With the Addition of Tucatinib

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
209