Success Metrics

Clinical Success Rate
82.5%

Based on 80 completed trials

Completion Rate
82%(80/97)
Active Trials
81(38%)
Results Posted
93%(74 trials)
Terminated
17(8%)

Phase Distribution

Ph phase_3
48
23%
Ph phase_2
112
53%
Ph not_applicable
3
1%
Ph early_phase_1
2
1%
Ph phase_4
5
2%
Ph phase_1
35
16%

Phase Distribution

37

Early Stage

112

Mid Stage

53

Late Stage

Phase Distribution205 total trials
Early Phase 1First-in-human
2(1.0%)
Phase 1Safety & dosage
35(17.1%)
Phase 2Efficacy & side effects
112(54.6%)
Phase 3Large-scale testing
48(23.4%)
Phase 4Post-market surveillance
5(2.4%)
N/ANon-phased studies
3(1.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

79.2%

80 of 101 finished

Non-Completion Rate

20.8%

21 ended early

Currently Active

81

trials recruiting

Total Trials

213

all time

Status Distribution
Active(100)
Completed(80)
Terminated(21)
Other(12)

Detailed Status

Completed80
Active, not recruiting42
Recruiting39
Not yet recruiting19
Terminated17
unknown12

Development Timeline

Analytics

Development Status

Total Trials
213
Active
81
Success Rate
82.5%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (1.0%)
Phase 135 (17.1%)
Phase 2112 (54.6%)
Phase 348 (23.4%)
Phase 45 (2.4%)
N/A3 (1.5%)

Trials by Status

active_not_recruiting4220%
terminated178%
unknown126%
withdrawn42%
completed8038%
not_yet_recruiting199%
recruiting3918%

Recent Activity

Clinical Trials (213)

Showing 20 of 213 trialsScroll for more
NCT06876714Phase 3

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

Recruiting
NCT07856303Phase 2

SHR-A1811 Versus Trastuzumab Plus Pertuzumab in ctDNA-Positive HER2-Positive Early Breast Cancer After Pathologic Complete Response

Not Yet Recruiting
NCT02326974Phase 2

T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA

Active Not Recruiting
NCT07102381Phase 2

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT05132582Phase 3

A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer

Active Not Recruiting
NCT07407920Phase 2

Ph2 Study for Optimization of Adjunct Systemic Therapy in HER2+ Patients, MolecularPCR Trial

Recruiting
NCT02390427Phase 1

Phase Ib Dose-escalation Trial of Taselisib (GDC-0032) in Combination With Anti-HER2 Therapies in Participants With Advanced HER2+ Breast Cancer

Completed
NCT03716180Phase 1

DAPHNe: Paclitaxel/Trastuzumab/Pertuzumab in HER2-Positive BC

Active Not Recruiting
NCT07829900

First-Line Dual Versus Single HER2-Targeted Therapy With Docetaxel for Advanced HER2-Positive Breast Cancer

Completed
NCT04208178Phase 3

Study of Alpelisib (BYL719) in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy in Patients With HER2-positive Advanced Breast Cancer With a PIK3CA Mutation

Active Not Recruiting
NCT07679269Phase 2

Roll-Over Study of Alpelisib (BYL719) for Continued Access and Long-Term Safety.

Not Yet Recruiting
NCT04266249Phase 2

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

Active Not Recruiting
NCT03006172Phase 1

To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

Active Not Recruiting
NCT07797218Phase 3

Neoadjuvant Pyrotinib-to-pertuzumab in HER2+ eBC

Recruiting
NCT00781612Phase 2

A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies

Active Not Recruiting
NCT06891833Phase 2

A Study of BL-M07D1 With or Without Pertuzumab Versus Docetaxel + Carboplatin + Trastuzumab + Pertuzumab in Neoadjuvant Therapy for HER2-Positive Breast Cancer

Recruiting
NCT03644186Phase 2

To Reduce the Use of Chemotherapy in Postmenopausal Patients With ER-positive and HER2-positive Breast Cancer (TOUCH)

Completed
NCT03417544Phase 2

Atezolizumab + Pertuzumab + Trastuzumab In CNS Mets In BC

Completed
NCT06441890Phase 2

BRE-10: Biomarker Optimization of Neoadjuvant Therapy in Breast Cancer

Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
213