Success Metrics

Clinical Success Rate
77.2%

Based on 98 completed trials

Completion Rate
77%(98/127)
Active Trials
143(46%)
Results Posted
96%(94 trials)
Terminated
29(9%)

Phase Distribution

Ph not_applicable
2
1%
Ph phase_1
95
30%
Ph phase_2
165
53%
Ph phase_3
31
10%
Ph phase_4
6
2%
Ph early_phase_1
9
3%

Phase Distribution

104

Early Stage

165

Mid Stage

37

Late Stage

Phase Distribution308 total trials
Early Phase 1First-in-human
9(2.9%)
Phase 1Safety & dosage
95(30.8%)
Phase 2Efficacy & side effects
165(53.6%)
Phase 3Large-scale testing
31(10.1%)
Phase 4Post-market surveillance
6(1.9%)
N/ANon-phased studies
2(0.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

71.0%

98 of 138 finished

Non-Completion Rate

29.0%

40 ended early

Currently Active

143

trials recruiting

Total Trials

314

all time

Status Distribution
Active(149)
Completed(98)
Terminated(40)
Other(27)

Detailed Status

Completed98
Active, not recruiting86
Recruiting57
Terminated29
unknown27
Withdrawn11

Development Timeline

Analytics

Development Status

Total Trials
314
Active
143
Success Rate
77.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 19 (2.9%)
Phase 195 (30.8%)
Phase 2165 (53.6%)
Phase 331 (10.1%)
Phase 46 (1.9%)
N/A2 (0.6%)

Trials by Status

unknown279%
completed9831%
enrolling_by_invitation10%
terminated299%
recruiting5718%
withdrawn114%
not_yet_recruiting52%
active_not_recruiting8627%

Recent Activity

Clinical Trials (314)

Showing 20 of 314 trialsScroll for more
NCT03880019Phase 2

A Phase II Clinical Trial Evaluating the Combination of Olaparib and Temozolomide for the Treatment of Advanced Uterine Leiomyosarcoma

Active Not Recruiting
NCT02345265Phase 2

Testing the Combination of the Study Drugs Cediranib and Olaparib in Recurrent Ovarian Cancer

Active Not Recruiting
NCT02893917Phase 2

Testing Two Oral Drugs Combination (Cediranib and Olaparib) Compared to a Single Drug (Olaparib) for Men With Advanced Prostate Cancer

Active Not Recruiting
NCT03842228Phase 1

Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations

Active Not Recruiting
NCT04034927Phase 2

Testing the Addition of an Immunotherapy Drug, Tremelimumab, to the PARP Inhibition Drug, Olaparib, for Recurrent Ovarian, Fallopian Tube or Peritoneal Cancer

Active Not Recruiting
NCT02446600Phase 3

Testing the Use of A Single Drug (Olaparib) or the Combination of Two Drugs (Cediranib and Olaparib) Compared to the Usual Chemotherapy for Women With Platinum Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Active Not Recruiting
NCT05564377Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting
NCT02849496Phase 2

Testing Olaparib Either Alone or in Combination With Atezolizumab in BRCA Mutant Non-HER2-positive Breast Cancer

Active Not Recruiting
NCT05554328Phase 2

Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

Active Not Recruiting
NCT03317392Phase 1

Testing the Safety of Different Doses of Olaparib Given Radium-223 for Men With Advanced Prostate Cancer With Bone Metastasis

Active Not Recruiting
NCT04585958Phase 1

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

Recruiting
NCT04858334Phase 2

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Recruiting
NCT03486873Phase 3

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Recruiting
NCT03259503Phase 1

Olaparib and High-Dose Chemotherapy in Treating Patients With Relapsed or Refractory Lymphomas Undergoing Stem Cell Transplant

Completed
NCT07652242Phase 1

Phase 1 Study of a Self-amplifying RNA Vaccine (ITI-5000) in Stage 2-3 Triple Negative Breast Cancer

Recruiting
NCT04086485Phase 1

Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)

Recruiting
NCT06966700Phase 3

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Recruiting
NCT06856499Phase 1

Cirtuvivint/Olaparib in Breast Cancer Susceptibility Gene/Homologous Recombination Deficiency Platinum Resistant Ovarian Cancer

Recruiting
NCT04053322Phase 2

Durvalumab, With Olaparib and Fulvestrant in Advanced ER+, HER2- Breast Cancer Patients.

Active Not Recruiting
NCT03155620Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
314