Success Metrics

Clinical Success Rate
82.1%

Based on 78 completed trials

Completion Rate
82%(78/95)
Active Trials
11(9%)
Results Posted
62%(48 trials)
Terminated
17(14%)

Phase Distribution

Ph early_phase_1
1
1%
Ph not_applicable
1
1%
Ph phase_2
48
39%
Ph phase_3
22
18%
Ph phase_4
15
12%
Ph phase_1
25
20%

Phase Distribution

26

Early Stage

48

Mid Stage

37

Late Stage

Phase Distribution112 total trials
Early Phase 1First-in-human
1(0.9%)
Phase 1Safety & dosage
25(22.3%)
Phase 2Efficacy & side effects
48(42.9%)
Phase 3Large-scale testing
22(19.6%)
Phase 4Post-market surveillance
15(13.4%)
N/ANon-phased studies
1(0.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

78.8%

78 of 99 finished

Non-Completion Rate

21.2%

21 ended early

Currently Active

11

trials recruiting

Total Trials

124

all time

Status Distribution
Active(12)
Completed(78)
Terminated(21)
Other(13)

Detailed Status

Completed78
Terminated17
unknown13
Active, not recruiting6
Recruiting5
Withdrawn4

Development Timeline

Analytics

Development Status

Total Trials
124
Active
11
Success Rate
82.1%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.9%)
Phase 125 (22.3%)
Phase 248 (42.9%)
Phase 322 (19.6%)
Phase 415 (13.4%)
N/A1 (0.9%)

Trials by Status

completed7863%
active_not_recruiting65%
recruiting54%
terminated1714%
unknown1310%
not_yet_recruiting11%
withdrawn43%

Recent Activity

Clinical Trials (124)

Showing 20 of 124 trialsScroll for more
NCT03516279Phase 2

Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease

Active Not Recruiting
NCT00756509Phase 4

Treatment of Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumors in First Line With Nilotinib

Completed
NCT03874858Phase 2

A Study of Full Treatment-free Remission in Patients With Chronic Myeloid Leukemia

Terminated
NCT04877522Phase 4

Asciminib Roll-over Study

Recruiting
NCT05185947Phase 2

Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis

Completed
NCT04971226Phase 3

A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP

Active Not Recruiting
NCT05456191Phase 3

A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib (Oral) in Adult Participants (≥18 Years of Age) With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP)

Active Not Recruiting
NCT01774630Phase 2

Multicenter Single-arm Pilot Study Evaluating Efficacy of Nilotinib in CML Patients With Molecular Relapse After Glivec Discontinuation Within the Context of the STIM Trials (STIM and STIM2)

Completed
NCT03784014Phase 3

Molecular Profiling of Advanced Soft-tissue Sarcomas

Completed
NCT03578367Phase 2

Study of Efficacy and Safety of Asciminib in Combination With Imatinib in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Who Have Been Previously Treated With Imatinib and Have Not Achieved Deep Molecular Response.

Completed
NCT07493408Phase 2

Asciminib & Standard-of-Care Integration in Maintenance Therapy for POST Allogeneic Stem Cell Transplant (Allo-HSCT) of Patient With Ph+ B-ALL or Blastic Transformed CML

Not Yet Recruiting
NCT01207492Phase 2

Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor

Completed
NCT01407198Phase 1

Nilotinib With Radiation for High Risk Chordoma

Completed
NCT03654768Phase 2

Testing the Addition of Ruxolitinib to the Usual Treatment (Tyrosine Kinase Inhibitors) for Chronic Myeloid Leukemia

Active Not Recruiting
NCT01316250Not Applicable

Gleevec as Maintenance Therapy After Cytogenetic Response With Nilotinib in Newly Diagnosed Chronic Myelogenous Leukemia

Completed
NCT02917720Phase 2

2nd or 3rd TKI-stop After 2 Years Nilotinib Pre-treatment in CML-patients

Active Not Recruiting
NCT01698905Phase 2

Treatment-free Remission After Achieving Sustained MR4.5 on Nilotinib (ENESTop)

Completed
NCT04838041Phase 2

Protocol Number: HJKC3-0003. Treatment Free Remission After Asciminib Based Therapy in Chronic Phase Chronic Myeloid Leukemia (CP-CML) Patients Who Relapsed After a Prior Attempt at TKI Discontinuation

Recruiting
NCT06409936Phase 2

PEARL Study: PotEntial of Asciminib in the eaRly Treatment of CML

Recruiting
NCT04205903Phase 1

Nilotinib in Preventing Paclitaxel-Induced Peripheral Neuropathy in Patients With Stage I-III Breast Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
124