Success Metrics

Clinical Success Rate
88.0%

Based on 22 completed trials

Completion Rate
88%(22/25)
Active Trials
4(14%)
Results Posted
91%(20 trials)
Terminated
3(10%)

Phase Distribution

Ph phase_1
19
66%
Ph phase_2
10
34%

Phase Distribution

19

Early Stage

10

Mid Stage

0

Late Stage

Phase Distribution29 total trials
Phase 1Safety & dosage
19(65.5%)
Phase 2Efficacy & side effects
10(34.5%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

88.0%

22 of 25 finished

Non-Completion Rate

12.0%

3 ended early

Currently Active

4

trials recruiting

Total Trials

29

all time

Status Distribution
Active(4)
Completed(22)
Terminated(3)

Detailed Status

Completed22
Terminated3
Active, not recruiting2
Recruiting2

Development Timeline

Analytics

Development Status

Total Trials
29
Active
4
Success Rate
88.0%
Most Advanced
Phase 2

Trials by Phase

Phase 119 (65.5%)
Phase 210 (34.5%)

Trials by Status

active_not_recruiting27%
completed2276%
terminated310%
recruiting27%

Recent Activity

Clinical Trials (29)

Showing 20 of 29 trialsScroll for more
NCT02852655Phase 1

A Pilot Surgical Trial To Evaluate Early Immunologic Pharmacodynamic Parameters For The PD-1 Checkpoint Inhibitor, Pembrolizumab (MK-3475), In Patients With Surgically Accessible Recurrent/Progressive Glioblastoma

Active Not Recruiting
NCT02422381Phase 1

MK-3475 and Gemcitabine in Non-Small Cell Lung Cancer (NSCLC)

Active Not Recruiting
NCT03003468Phase 1

Pembrolizumab + Imprime PGG for Metastatic Non-small Cell Lung Cancer After Progression on First-Line Therapy: Big Ten Cancer Research Consortium BTCRC-LUN15-017

Completed
NCT02512172Phase 1

A Study of Enhancing Response to MK-3475 in Advanced Colorectal Cancer

Completed
NCT05879653Phase 2

Pembrolizumab and EV With Radiation Therapy for MIBC Patients (PEVRAD)

Recruiting
NCT02311582Phase 1

MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas

Completed
NCT02318771Phase 1

Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer

Completed
NCT04098068Phase 2

Study of MK-3475 (Pembrolizumab) in Patients With Microsatellite Unstable (MSI) Tumors (Cohort D)

Completed
NCT02289209Phase 2

Reirradiation With Pembrolizumab in Locoregional Inoperable Recurrence or Second Primary Squamous Cell CA of the Head and Neck

Completed
NCT02630823Phase 1

MK-3475 Immunotherapy in Endometrial Carcinoma

Completed
NCT02407171Phase 1

Evaluating the Combination of MK-3475 and Sterotactic Body Radiotherapy in Patients With Metastatic Melanoma or NSCLC

Completed
NCT05832827Phase 2

First-line CBDCA/PTX/LEN/Pembrolizumab Combination for Previously Untreated Advanced or Recurrent Thymic Carcinomas (Artemis)

Recruiting
NCT02591615Phase 2

Optimal Sequencing of Pembrolizumab (MK-3475) and Standard Platinum-based Chemotherapy in First-Line NSCLC

Completed
NCT02348008Phase 1

Phase Ib and Phase II Studies of MK-3475 in Combination + for Renal Cell Carcinoma:

Completed
NCT02535247Phase 1

Study of MK-3475 Alone or in Combination With Copanlisib in Relapsed or Refractory NK and T-cell Non-Hodgkin Lymphoma

Terminated
NCT03110328Phase 2

Study of Pembrolizumab in Metastatic Biliary Tract Cancer as Second-line Treatment After Failing to at Least One Cytotoxic Chemotherapy Regimen: Integration of Genomic Analysis to Identify Predictive Molecular Subtypes

Completed
NCT02178722Phase 1

Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers

Completed
NCT02133742Phase 1

A Dose Finding Study To Evaluate Safety, Drug Interaction, Tumor Markers Of Axitinib In Combination With MK-3475 In Adult Patients With Previously Untreated Advanced Renal Cell Cancer

Completed
NCT02112032Phase 1

Treatment of Advanced Melanoma With MK-3475 and Peginterferon

Completed
NCT02085070Phase 2

MK-3475 in Melanoma and NSCLC Patients With Brain Metastases

Completed

Drug Details

Intervention Type
DRUG
Total Trials
29