Success Metrics

Clinical Success Rate
73.9%

Based on 17 completed trials

Completion Rate
74%(17/23)
Active Trials
6(15%)
Results Posted
71%(12 trials)
Terminated
6(15%)

Phase Distribution

Ph phase_3
6
15%
Ph phase_1
13
33%
Ph phase_2
16
41%

Phase Distribution

13

Early Stage

16

Mid Stage

6

Late Stage

Phase Distribution35 total trials
Phase 1Safety & dosage
13(37.1%)
Phase 2Efficacy & side effects
16(45.7%)
Phase 3Large-scale testing
6(17.1%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

63.0%

17 of 27 finished

Non-Completion Rate

37.0%

10 ended early

Currently Active

6

trials recruiting

Total Trials

39

all time

Status Distribution
Active(6)
Completed(17)
Terminated(10)
Other(6)

Detailed Status

Completed17
unknown6
Terminated6
Active, not recruiting4
Withdrawn4
Recruiting2

Development Timeline

Analytics

Development Status

Total Trials
39
Active
6
Success Rate
73.9%
Most Advanced
Phase 3

Trials by Phase

Phase 113 (37.1%)
Phase 216 (45.7%)
Phase 36 (17.1%)

Trials by Status

recruiting25%
unknown615%
active_not_recruiting410%
withdrawn410%
completed1744%
terminated615%

Recent Activity

Clinical Trials (39)

Showing 20 of 39 trialsScroll for more
NCT03591510Phase 2

A Global Study of Midostaurin in Combination With Chemotherapy to Evaluate Safety, Efficacy and Pharmacokinetics in Newly Diagnosed Pediatric Patients With FLT3 Mutated AML

Active Not Recruiting
NCT03258931Phase 3

Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated AML

Completed
NCT06313437Phase 1

Revumenib in Combination With 7+3 + Midostaurin in AML

Recruiting
NCT02115295Phase 2

Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid Leukemia

Recruiting
NCT03900949Phase 1

Gentuzumab Ozogamicin and Midostaurin Combination With Standard Cytarabine and Danunorubi Midostaurin as a Novel Approach to Treating Patients With Newly Diagnosed FLT-3 Mutated Acute Myeloid Leukemia

Completed
NCT03836209Phase 2

Gilteritinib vs Midostaurin in FLT3 Mutated Acute Myeloid Leukemia

Active Not Recruiting
NCT03280030Phase 2

A Study of Midostaurin Efficacy and Safety in Newly Diagnosed Patients With FLT3-mutated AML

Completed
NCT03686345Phase 2

Midostaurin Associated With Standard Chemotherapy in Patients With Core-binding Factor Leukemia

Terminated
NCT03092674Phase 2

Azacitidine With or Without Nivolumab or Midostaurin, or Decitabine and Cytarabine Alone in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Completed
NCT04027309Phase 3

A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy

Active Not Recruiting
NCT04982354Phase 1

Induction Therapy for Patients With FLT3 Mutated Acute Myeloid Leukemia

Withdrawn
NCT04097470Phase 2

Tolerability and Efficacy of Midostaurin to 10-day Decitabine in Unfit Adult AML and High Risk MDS Patients

Active Not Recruiting
NCT05219266

Managed Access Programs for PKC412, Midostaurin

Unknown
NCT03379727Phase 3

Study to Assess the Safety and Efficacy of Midostaurin (PKC412) in Combination With Standard Chemotherapy During Induction and Consolidation Followed by 12 Months of Maintenance Monotherapy in Patients With Newly-diagnosed FMS-like Tyrosine 3 (FLT3) Kinase Receptor-mutated Acute Myeloid Leukemia.

Completed
NCT04075747Phase 1

A Phase 1b Master Trial to Investigate CPX-351 in Subjects With Previously Untreated Acute Myeloid Leukemia

Completed
NCT03512197Phase 3

A Global Study of the Efficacy and Safety of Midostaurin + Chemotherapy in Newly Diagnosed Patients With FLT3 Mutation Negative (FLT3-MN) Acute Myeloid Leukemia (AML)

Completed
NCT05488613

Healthcare Resource Utilization in Adults Diagnosed With Acute Myeloid Leukemia (AML)

Completed
NCT04496999Phase 1

HDM201 and Midostaurin (HDMM) in Relapsed/Refractory AML With FLT3mut and TP53wt.

Terminated
NCT01093573Phase 1

Midostaurin and Azacitidine in Treating Elderly Patients With Acute Myelogenous Leukemia

Completed
NCT04174612Phase 3

AML Patients Bearing FLT3 Mutations Based on Peripheral Blast Clearance

Unknown

Drug Details

Intervention Type
DRUG
Total Trials
39