Success Metrics

Clinical Success Rate
92.9%

Based on 39 completed trials

Completion Rate
93%(39/42)
Active Trials
10(16%)
Results Posted
85%(33 trials)
Terminated
3(5%)

Phase Distribution

Ph phase_2
9
14%
Ph early_phase_1
1
2%
Ph phase_1
4
6%
Ph not_applicable
2
3%
Ph phase_3
25
39%
Ph phase_4
10
16%

Phase Distribution

5

Early Stage

9

Mid Stage

35

Late Stage

Phase Distribution51 total trials
Early Phase 1First-in-human
1(2.0%)
Phase 1Safety & dosage
4(7.8%)
Phase 2Efficacy & side effects
9(17.6%)
Phase 3Large-scale testing
25(49.0%)
Phase 4Post-market surveillance
10(19.6%)
N/ANon-phased studies
2(3.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

90.7%

39 of 43 finished

Non-Completion Rate

9.3%

4 ended early

Currently Active

10

trials recruiting

Total Trials

64

all time

Status Distribution
Active(12)
Completed(39)
Terminated(4)
Other(9)

Detailed Status

Completed39
unknown9
Active, not recruiting6
Recruiting4
Terminated3
Not yet recruiting2

Development Timeline

Analytics

Development Status

Total Trials
64
Active
10
Success Rate
92.9%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (2.0%)
Phase 14 (7.8%)
Phase 29 (17.6%)
Phase 325 (49.0%)
Phase 410 (19.6%)
N/A2 (3.9%)

Trials by Status

not_yet_recruiting23%
withdrawn12%
recruiting46%
terminated35%
unknown914%
active_not_recruiting69%
completed3961%

Recent Activity

Clinical Trials (64)

Showing 20 of 64 trialsScroll for more
NCT04965636Phase 3

Study in Pediatrics With HypEREosinophilic Syndrome (SPHERE)

Completed
NCT04075331Phase 2

Mepolizumab for COPD Hospital Eosinophilic Admissions Pragmatic Trial

Completed
NCT04823585Phase 4

Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab)

Completed
NCT04157348Phase 3

Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.

Active Not Recruiting
NCT05895929Early Phase 1

The Role of IL5 in Epithelial Cell Integrity

Recruiting
NCT05063981

Treatment With Mepolizumab on Patients With Severe Refractory Eosinophilic Asthma

Completed
NCT05030155Phase 3

Study of Mepolizumab-based Regimen Compared to Conventional Therapeutic Strategy in Patients With Eosinophilic Granulomatosis With Polyangiitis (E-merge)

Active Not Recruiting
NCT05263934Phase 3

Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)

Active Not Recruiting
NCT04718389Phase 3

A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype

Completed
NCT07200336Phase 4

Anti-IL-5 Therapy With Simple Polypectomy Versus Extended Endoscopic Sinus Surgery for CRSwNP

Not Yet Recruiting
NCT01463644Phase 3

Mepolizumab in Chronic Obstructive Pulmonary Diseases (COPD) With Eosinophilic Bronchitis

Completed
NCT04765722Phase 4

Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases

Completed
NCT04133909Phase 3

Mepolizumab as Add-on Treatment IN Participants With COPD Characterized by Frequent Exacerbations and Eosinophil Level

Completed
NCT06041386Phase 4

REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study

Active Not Recruiting
NCT05942222Phase 4

A Real-world, Head-to-head Comparison of Dupilumab Versus Mepolizumab in Danish Patients With Chronic Rhinosinusitis With Nasal Polyps

Active Not Recruiting
NCT00244686

This Record Contains Information About the Mepolizumab Compassionate Use (CU) Product Activities: 104317: CU and Long-Term Access Study of Mepolizumab in HES. 201956:A Long-term Access Programme for Subjects With Severe Asthma 112562: Expanded Access for Patients With Hypereosinophilic

Unknown
NCT05147155

Impulse Oscillometry Measurements in Severe Eosinophilic Asthmatics Before and After Anti-IL-5 Factor Initiation

Completed
NCT04578171

Residual Exacerbations With Mepolizumab

Recruiting
NCT04276233Phase 4

Efficacy and Safety Study of Mepolizumab 100 Milligram (mg) Subcutaneous (SC) in Indian Participants Aged Greater Than or Equal to (>=) 18 Years With Severe Eosinophilic Asthma

Completed
NCT04607005Phase 3

Efficacy and Safety of Mepolizumab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)/ Eosinophilic Chronic Rhinosinusitis (ECRS)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
64