Success Metrics

Clinical Success Rate
80.0%

Based on 16 completed trials

Completion Rate
80%(16/20)
Active Trials
1(5%)
Results Posted
75%(12 trials)
Terminated
4(18%)

Phase Distribution

Ph phase_3
2
9%
Ph phase_2
6
27%
Ph phase_1
14
64%

Phase Distribution

14

Early Stage

6

Mid Stage

2

Late Stage

Phase Distribution22 total trials
Phase 1Safety & dosage
14(63.6%)
Phase 2Efficacy & side effects
6(27.3%)
Phase 3Large-scale testing
2(9.1%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

76.2%

16 of 21 finished

Non-Completion Rate

23.8%

5 ended early

Currently Active

1

trials recruiting

Total Trials

22

all time

Status Distribution
Active(1)
Completed(16)
Terminated(5)

Detailed Status

Completed16
Terminated4
Active, not recruiting1
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
22
Active
1
Success Rate
80.0%
Most Advanced
Phase 3

Trials by Phase

Phase 114 (63.6%)
Phase 26 (27.3%)
Phase 32 (9.1%)

Trials by Status

active_not_recruiting15%
terminated418%
completed1673%
withdrawn15%

Recent Activity

Clinical Trials (22)

Showing 20 of 22 trialsScroll for more
NCT01909453Phase 3

Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma

Completed
NCT01991379Phase 1

MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)

Active Not Recruiting
NCT02285439Phase 1

Study of MEK162 for Children With Low-Grade Gliomas

Completed
NCT02631447Phase 2

Sequential Combo Immuno and Target Therapy (SECOMBIT) Study

Completed
NCT01543698Phase 1

A Phase Ib/II Study of LGX818 in Combination With MEK162 in Adult Patients With BRAF Dependent Advanced Solid Tumors

Completed
NCT02159066Phase 2

LGX818 and MEK162 in Combination With a Third Agent (BKM120, LEE011, BGJ398 or INC280) in Advanced BRAF Melanoma

Completed
NCT01320085Phase 2

A Phase II Study of Single Agent MEK162 in Patients With Advanced Melanoma

Completed
NCT01859026Phase 1

A Phase I/IB Trial of MEK162 in Combination With Erlotinib in NSCLC Harboring KRAS or EGFR Mutation

Completed
NCT03158103Phase 1

A Study of MEK162 (Binimetinib) in Combination With Pexidartinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST)

Completed
NCT01763164Phase 3

Study Comparing the Efficacy of MEK162 Versus Dacarbazine in Unresectable or Metastatic NRAS Mutation-positive Melanoma

Completed
NCT01885195Phase 2

MEK162 for Patients With RAS/RAF/MEK Activated Tumors

Completed
NCT01927341Phase 1

Phase Ib/II Study of Efficacy and Safety of MEK162 and Panitumumab, in Adult mCRC Patients With Mutant or Wild-type RAS Tumors

Completed
NCT02276027Phase 2

A Phase II, Open Label, Multiple Arm Study of AUY922, BYL719, INC280, LDK378 and MEK162 in Chinese Patients With Advanced Non-small Cell Lung Cancer

Completed
NCT01562899Phase 1

A Study of MEK162 and AMG 479 in Patients With Selected Solid Tumors

Terminated
NCT01781572Phase 1

A Phase Ib/II Study of LEE011 in Combination With MEK162 in Patients With NRAS Mutant Melanoma

Completed
NCT01828034Phase 1

First Line Gemcitabine, Cisplatin and MEK162 in Advanced Biliary Tract Carcinoma

Completed
NCT01556568Phase 2

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MEK162 in Noonan Syndrome Hypertrophic Cardiomyopathy

Withdrawn
NCT01469130Phase 1

A Phase I Study of Oral MEK162 in Japanese Patients With Advanced Solid Tumors

Completed
NCT02050815Phase 1

MEK162 in Healthy Subjects With Normal Hepatic Function and Subjects With Impaired Hepatic Function

Terminated
NCT01801358Phase 1

A Phase Ib/II Study of AEB071 and MEK162 in Adult Patients With Metastatic Uveal Melanoma

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
22