Success Metrics

Clinical Success Rate
62.5%

Based on 10 completed trials

Completion Rate
63%(10/16)
Active Trials
6(27%)
Results Posted
160%(16 trials)
Terminated
6(27%)

Phase Distribution

Ph phase_2
6
27%
Ph phase_1
15
68%
Ph phase_3
1
5%

Phase Distribution

15

Early Stage

6

Mid Stage

1

Late Stage

Phase Distribution22 total trials
Phase 1Safety & dosage
15(68.2%)
Phase 2Efficacy & side effects
6(27.3%)
Phase 3Large-scale testing
1(4.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

62.5%

10 of 16 finished

Non-Completion Rate

37.5%

6 ended early

Currently Active

6

trials recruiting

Total Trials

22

all time

Status Distribution
Active(6)
Completed(10)
Terminated(6)

Detailed Status

Completed10
Terminated6
Active, not recruiting3
Recruiting3

Development Timeline

Analytics

Development Status

Total Trials
22
Active
6
Success Rate
62.5%
Most Advanced
Phase 3

Trials by Phase

Phase 115 (68.2%)
Phase 26 (27.3%)
Phase 31 (4.5%)

Trials by Status

completed1045%
active_not_recruiting314%
terminated627%
recruiting314%

Recent Activity

Clinical Trials (22)

Showing 20 of 22 trialsScroll for more
NCT04303117Phase 1

PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

Recruiting
NCT04235777Phase 1

Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

Recruiting
NCT04287868Phase 1

Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies

Active Not Recruiting
NCT04633252Phase 1

A Phase I/II Study of PDS01ADC With Docetaxel and Abiraterone in Adults With Metastatic Castration Sensitive and PDS01ADC With Docetaxel in Castration Resistant Prostate Cancer

Recruiting
NCT04417660Phase 2

Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma

Active Not Recruiting
NCT04432597Phase 1

HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers

Active Not Recruiting
NCT03493945Phase 1

Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat (QuEST1)

Completed
NCT04247282Phase 1

Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection

Completed
NCT03554473Phase 1

M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung Cancers

Completed
NCT03631706Phase 3

M7824 Versus Pembrolizumab as a First-line (1L) Treatment in Participants With Programmed Death-ligand 1 (PD-L1) Expressing Advanced Non-small Cell Lung Cancer (NSCLC)

Completed
NCT04574583Phase 1

Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With BinTrafusp Alfa (M7824 or TGF-beta "Trap"/PD-L1) With CV301 TRICOM in Advanced Solid Tumors (STAT)

Completed
NCT04551950Phase 1

Bintrafusp Alfa Combination Therapy in Participants With Cervical Cancer (INTR@PID 046)

Completed
NCT03840902Phase 2

M7824 With cCRT in Unresectable Stage III Non-small Cell Lung Cancer (NSCLC)

Terminated
NCT04066491Phase 2

Gemcitabine Plus Cisplatin With or Without Bintrafusp Alfa (M7824) in Participants With 1L BTC

Terminated
NCT03833661Phase 2

M7824 Monotherapy in Locally Advanced or Metastatic Second Line (2L) Biliary Tract Cancer (Cholangiocarcinoma and Gallbladder Cancer)

Completed
NCT03840915Phase 1

M7824 in Combination With Chemotherapy in Stage IV Non-small Cell Lung Cancer (NSCLC)

Completed
NCT03427411Phase 2

M7824 in Subjects With HPV Associated Malignancies

Completed
NCT04297748Phase 1

Bioimaging Study of 89Zr-M7824 in NSCLC

Terminated
NCT03707587Phase 2

M7824 in People With Recurrent Respiratory Papillomatosis

Completed
NCT04327986Phase 1

Immune Checkpoint Inhibitor M7824 and the Immunocytokine M9241 in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Advanced Pancreas Cancer

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
22