Success Metrics

Clinical Success Rate
73.6%

Based on 92 completed trials

Completion Rate
74%(92/125)
Active Trials
3(2%)
Results Posted
78%(72 trials)
Terminated
33(23%)

Phase Distribution

Ph phase_1
40
28%
Ph phase_2
74
51%
Ph phase_3
22
15%
Ph phase_4
1
1%
Ph early_phase_1
4
3%
Ph not_applicable
2
1%

Phase Distribution

44

Early Stage

74

Mid Stage

23

Late Stage

Phase Distribution143 total trials
Early Phase 1First-in-human
4(2.8%)
Phase 1Safety & dosage
40(28.0%)
Phase 2Efficacy & side effects
74(51.7%)
Phase 3Large-scale testing
22(15.4%)
Phase 4Post-market surveillance
1(0.7%)
N/ANon-phased studies
2(1.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

70.8%

92 of 130 finished

Non-Completion Rate

29.2%

38 ended early

Currently Active

3

trials recruiting

Total Trials

144

all time

Status Distribution
Active(3)
Completed(92)
Terminated(38)
Other(11)

Detailed Status

Completed92
Terminated33
unknown11
Withdrawn5
Active, not recruiting3

Development Timeline

Analytics

Development Status

Total Trials
144
Active
3
Success Rate
73.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 14 (2.8%)
Phase 140 (28.0%)
Phase 274 (51.7%)
Phase 322 (15.4%)
Phase 41 (0.7%)
N/A2 (1.4%)

Trials by Status

unknown118%
active_not_recruiting32%
completed9264%
withdrawn53%
terminated3323%

Recent Activity

Clinical Trials (144)

Showing 20 of 144 trialsScroll for more
NCT01947023Phase 1

Dabrafenib and Lapatinib in Treating Patients With Refractory Thyroid Cancer That Cannot Be Removed by Surgery

Active Not Recruiting
NCT03784014Phase 3

Molecular Profiling of Advanced Soft-tissue Sarcomas

Completed
NCT01612351Phase 2

Multimodality Risk Adapted Tx Including Induction Chemo for SCCHN Amenable to Transoral Surgery

Completed
NCT03523585Phase 3

DS-8201a in Pre-treated HER2 Breast Cancer That Cannot be Surgically Removed or Has Spread [DESTINY-Breast02]

Completed
NCT00680901Phase 3

LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib

Completed
NCT02230553Phase 1

Lapatinib Plus Trametinib in KRAS Mutant NSCLC

Completed
NCT01273610Phase 2

Tolerability of the Combination of Lapatinib and Trastuzumab in Adults Age 60 or Older With HER2 Positive Locally Advanced or Metastatic Breast Cancer

Active Not Recruiting
NCT01526369Phase 3

A Randomized Study of TH Versus THL in First Line Treatment of HER2-positive Metastatic Breast Cancer

Completed
NCT00490139Phase 3

ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D

Completed
NCT00999804Phase 2

Extension Study of Lapatinib Plus Herceptin With or Without Endocrine Therapy

Active Not Recruiting
NCT01160211Phase 3

A Study to Compare the Safety and Efficacy of an Aromatase Inhibitor in Combination With Lapatinib, Trastuzumab or Both for the Treatment of Hormone Receptor Positive, HER2+ Metastatic Breast Cancer

Completed
NCT00470704Phase 2

Lapatinib in Combination With Trastuzumab in Patients With HER2-Positive, Metastatic Breast Cancer

Completed
NCT02101905Phase 1

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

Completed
NCT01306045Phase 2

Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies

Completed
NCT00963547Phase 1

A Study of MK-2206 in Combination With Trastuzumab and Lapatinib for the Treatment of HER2+ Solid Tumors (MK-2206-015)

Terminated
NCT03500380Phase 2

A Study of RC48-ADC Administered Intravenously to Patients With HER2-Positive Metastatic Breast Cancer With or Without Liver Metastases

Unknown
NCT01300962Phase 1

Study of BKM120 or BYL719 and Capecitabine in Patients With Metastatic Breast Cancer

Completed
NCT01711658Phase 2

TRYHARD: Radiation Therapy Plus Cisplatin With or Without Lapatinib in Treating Patients With Head and Neck Cancer.

Completed
NCT04591431Phase 2

The Rome Trial From Histology to Target: the Road to Personalize Target Therapy and Immunotherapy

Unknown
NCT01138384Phase 1

Study of Foretinib in Combination With Lapatinib in Patients With Metastatic Breast Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
144