Success Metrics

Clinical Success Rate
50.0%

Based on 4 completed trials

Completion Rate
50%(4/8)
Active Trials
5(26%)
Results Posted
25%(1 trials)
Terminated
4(21%)

Phase Distribution

Ph phase_1
5
26%
Ph phase_2
12
63%
Ph phase_3
2
11%

Phase Distribution

5

Early Stage

12

Mid Stage

2

Late Stage

Phase Distribution19 total trials
Phase 1Safety & dosage
5(26.3%)
Phase 2Efficacy & side effects
12(63.2%)
Phase 3Large-scale testing
2(10.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

50.0%

4 of 8 finished

Non-Completion Rate

50.0%

4 ended early

Currently Active

5

trials recruiting

Total Trials

19

all time

Status Distribution
Active(6)
Completed(4)
Terminated(4)
Other(5)

Detailed Status

unknown5
Recruiting4
Terminated4
Completed4
Active, not recruiting1
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
19
Active
5
Success Rate
50.0%
Most Advanced
Phase 3

Trials by Phase

Phase 15 (26.3%)
Phase 212 (63.2%)
Phase 32 (10.5%)

Trials by Status

recruiting421%
terminated421%
completed421%
unknown526%
active_not_recruiting15%
not_yet_recruiting15%

Recent Activity

Clinical Trials (19)

Showing 19 of 19 trials
NCT05827796Phase 1

IN10018+ Standard Chemotherapy (+KN046) in Subjects With Advanced Pancreatic Cancer

Recruiting
NCT04542837Phase 2

The Study of KN046 in Combination With Lenvatinib in Advanced Hepatocellular Carcinoma

Completed
NCT05832892Phase 1

Surufatinib Combined With KN046 and AG Regimen Chemotherapy as First-Line Treatment for Unresectable Advanced Pancreatic Cancer

Unknown
NCT06023758Phase 2

Phase 2 Trial of KN026+KN046±XELOX in HER2-positive Locally Advanced GC

Recruiting
NCT04925947Phase 2

A Study of KN046 in Patients With Thymic Carcinoma Who Failed Immune Checkpoint Inhibitors

Terminated
NCT05149326Phase 3

KN046 in Subjects With Advanced Pancreatic Ductal Adenocarcinoma.

Active Not Recruiting
NCT04469725Phase 2

KN046 (a Humanized PD-L1/CTLA4 Bispecific Single Domain Fc Fusion Protein Antibody) in Subjects With Thymic Carcinoma

Terminated
NCT05985109Phase 2

KN 046 Plus Regorafenib in MSS Metastatic Colorectal Cancer

Recruiting
NCT06099821Phase 2

KN046 Plus Regorafenib or Apatinib in MSI-H Digestive System Cancers Resistant to PD-1/PD-L1 Blockade

Recruiting
NCT05985707Phase 2

KN026 Plus Chemotherapy ± KN-046 in HER2 Positive Colorectal Cancer and Biliary Carcinoma

Not Yet Recruiting
NCT03733951Phase 1

KN046 in Subjects With Advanced Solid Tumors and Lymphoma

Completed
NCT03872791Phase 1

A Study of KN046 in Subjects With Locally Advanced or Metastatic Triple-negative Breast Cancer

Completed
NCT05001724Phase 2

KN046 Plus Lenvatinib in Subject With Advanced Non-Small Cell Lung Cancer in the Failure of Anti-PD-(L)1 Agent

Terminated
NCT03838848Phase 2

KN046 in Patients With Advanced Non-small Cell Lung Cancer

Terminated
NCT03925870Phase 2

KN046 in Subjects With Late Stage Esophageal Squamous Cell Carcinoma

Completed
NCT04474119Phase 3

KN046 in Subjects With Advanced Squamous Non-small Cell Lung Cancer

Unknown
NCT04054531Phase 2

Study of KN046 With Chemotherapy in First Line Advanced NSCLC

Unknown
NCT03927495Phase 2

KN046 in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma

Unknown
NCT03529526Phase 1

Study of the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Antitumor Activity of KN046 in Subjects With Advanced Solid Tumors

Unknown

All 19 trials loaded

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
19