Success Metrics

Clinical Success Rate
92.7%

Based on 38 completed trials

Completion Rate
93%(38/41)
Active Trials
3(7%)
Results Posted
100%(38 trials)
Terminated
3(7%)

Phase Distribution

Ph phase_3
34
74%
Ph phase_1
4
9%
Ph phase_2
6
13%

Phase Distribution

4

Early Stage

6

Mid Stage

34

Late Stage

Phase Distribution44 total trials
Phase 1Safety & dosage
4(9.1%)
Phase 2Efficacy & side effects
6(13.6%)
Phase 3Large-scale testing
34(77.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

92.7%

38 of 41 finished

Non-Completion Rate

7.3%

3 ended early

Currently Active

3

trials recruiting

Total Trials

46

all time

Status Distribution
Active(3)
Completed(38)
Terminated(3)
Other(2)

Detailed Status

Completed38
Terminated3
Active, not recruiting3
unknown2

Development Timeline

Analytics

Development Status

Total Trials
46
Active
3
Success Rate
92.7%
Most Advanced
Phase 3

Trials by Phase

Phase 14 (9.1%)
Phase 26 (13.6%)
Phase 334 (77.3%)

Trials by Status

completed3883%
unknown24%
terminated37%
active_not_recruiting37%

Recent Activity

Clinical Trials (46)

Showing 20 of 46 trialsScroll for more
NCT05331183Phase 3

Study to Evaluate Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) Long-term Safety and Efficacy in Subjects Without F508del

Active Not Recruiting
NCT06460506Phase 3

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older

Active Not Recruiting
NCT05668741Phase 1

A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)

Active Not Recruiting
NCT05153317Phase 3

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis (CF) Participants 2 Years and Older

Completed
NCT05882357Phase 3

Evaluation of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis (CF) Participants 12 to Less Than 24 Months of Age

Completed
NCT04969224Phase 3

A Study to Evaluate ELX/TEZ/IVA on Cough and Physical Activity in Participants With Cystic Fibrosis (CF)

Completed
NCT03525574Phase 3

A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Completed
NCT04183790Phase 3

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA TC Combination Therapy in Participants With Cystic Fibrosis Who Are 6 Years of Age and Older

Completed
NCT03277196Phase 3

A Study to Evaluate the Safety of Long-term Ivacaftor Treatment in Participants With Cystic Fibrosis Who Are Less Than 24 Months of Age at Treatment Initiation and Have an Approved Ivacaftor-Responsive Mutation

Completed
NCT05033080Phase 3

A Phase 3 Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Heterozygous for F508del and a Minimal Function Mutation (F/MF)

Completed
NCT05274269Phase 3

Evaluation of Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis Subjects Without an F508del Mutation

Completed
NCT05076149Phase 3

A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation

Completed
NCT04545515Phase 3

A Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis (CF) Particpants 6 Years and Older and F/MF Genotypes

Completed
NCT03537651Phase 3

A Study to Evaluate the Safety and Efficacy of Long-term Treatment With TEZ/IVA in CF Participants With an F508del CFTR Mutation

Completed
NCT04058366Phase 3

Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Completed
NCT02565914Phase 3

A Study to Evaluate the Safety and Efficacy of Long Term Treatment With VX-661 in Combination With Ivacaftor in Participants With Cystic Fibrosis Who Have an F508del-CFTR Mutation

Completed
NCT02725567Phase 3

A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation

Completed
NCT04599465Phase 3

A Study to Assess the Effect of ELX/TEZ/IVA on Glucose Tolerance in Participants With Cystic Fibrosis (CF)

Completed
NCT04362761Phase 3

A Study Evaluating the Long-Term Safety of Elexacaftor Combination Therapy

Completed
NCT05111145Phase 3

A Study Evaluating the Safety of Elexacaftor/Tezacaftor/Ivacaftor in Participants With Cystic Fibrosis (CF)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
46