Success Metrics

Clinical Success Rate
92.7%

Based on 38 completed trials

Completion Rate
93%(38/41)
Active Trials
3(7%)
Results Posted
100%(38 trials)
Terminated
3(7%)

Phase Distribution

Ph phase_2
6
13%
Ph phase_3
34
74%
Ph phase_1
4
9%

Phase Distribution

4

Early Stage

6

Mid Stage

34

Late Stage

Phase Distribution44 total trials
Phase 1Safety & dosage
4(9.1%)
Phase 2Efficacy & side effects
6(13.6%)
Phase 3Large-scale testing
34(77.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

92.7%

38 of 41 finished

Non-Completion Rate

7.3%

3 ended early

Currently Active

3

trials recruiting

Total Trials

46

all time

Status Distribution
Active(3)
Completed(38)
Terminated(3)
Other(2)

Detailed Status

Completed38
Terminated3
Active, not recruiting2
unknown2
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
46
Active
3
Success Rate
92.7%
Most Advanced
Phase 3

Trials by Phase

Phase 14 (9.1%)
Phase 26 (13.6%)
Phase 334 (77.3%)

Trials by Status

active_not_recruiting24%
recruiting12%
terminated37%
unknown24%
completed3883%

Recent Activity

Clinical Trials (46)

Showing 20 of 46 trialsScroll for more
NCT05668741Phase 1

A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)

Recruiting
NCT05153317Phase 3

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis (CF) Participants 2 Years and Older

Completed
NCT05331183Phase 3

Study to Evaluate Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) Long-term Safety and Efficacy in Subjects Without F508del

Active Not Recruiting
NCT06460506Phase 3

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older

Active Not Recruiting
NCT05882357Phase 3

Evaluation of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis (CF) Participants 12 to Less Than 24 Months of Age

Completed
NCT04969224Phase 3

A Study to Evaluate ELX/TEZ/IVA on Cough and Physical Activity in Participants With Cystic Fibrosis (CF)

Completed
NCT03525574Phase 3

A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Completed
NCT04183790Phase 3

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA TC Combination Therapy in Participants With Cystic Fibrosis Who Are 6 Years of Age and Older

Completed
NCT03277196Phase 3

A Study to Evaluate the Safety of Long-term Ivacaftor Treatment in Participants With Cystic Fibrosis Who Are Less Than 24 Months of Age at Treatment Initiation and Have an Approved Ivacaftor-Responsive Mutation

Completed
NCT05033080Phase 3

A Phase 3 Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Heterozygous for F508del and a Minimal Function Mutation (F/MF)

Completed
NCT05274269Phase 3

Evaluation of Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis Subjects Without an F508del Mutation

Completed
NCT05076149Phase 3

A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation

Completed
NCT04545515Phase 3

A Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis (CF) Particpants 6 Years and Older and F/MF Genotypes

Completed
NCT03537651Phase 3

A Study to Evaluate the Safety and Efficacy of Long-term Treatment With TEZ/IVA in CF Participants With an F508del CFTR Mutation

Completed
NCT04058366Phase 3

Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Completed
NCT02565914Phase 3

A Study to Evaluate the Safety and Efficacy of Long Term Treatment With VX-661 in Combination With Ivacaftor in Participants With Cystic Fibrosis Who Have an F508del-CFTR Mutation

Completed
NCT02725567Phase 3

A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation

Completed
NCT04599465Phase 3

A Study to Assess the Effect of ELX/TEZ/IVA on Glucose Tolerance in Participants With Cystic Fibrosis (CF)

Completed
NCT04362761Phase 3

A Study Evaluating the Long-Term Safety of Elexacaftor Combination Therapy

Completed
NCT05111145Phase 3

A Study Evaluating the Safety of Elexacaftor/Tezacaftor/Ivacaftor in Participants With Cystic Fibrosis (CF)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
46