Success Metrics

Clinical Success Rate
91.2%

Based on 62 completed trials

Completion Rate
91%(62/68)
Active Trials
10(10%)
Results Posted
40%(25 trials)
Terminated
6(6%)

Phase Distribution

Ph phase_3
19
20%
Ph phase_1
28
29%
Ph not_applicable
8
8%
Ph phase_4
10
10%
Ph early_phase_1
3
3%
Ph phase_2
25
26%

Phase Distribution

31

Early Stage

25

Mid Stage

29

Late Stage

Phase Distribution93 total trials
Early Phase 1First-in-human
3(3.2%)
Phase 1Safety & dosage
28(30.1%)
Phase 2Efficacy & side effects
25(26.9%)
Phase 3Large-scale testing
19(20.4%)
Phase 4Post-market surveillance
10(10.8%)
N/ANon-phased studies
8(8.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

83.8%

62 of 74 finished

Non-Completion Rate

16.2%

12 ended early

Currently Active

10

trials recruiting

Total Trials

97

all time

Status Distribution
Active(12)
Completed(62)
Terminated(12)
Other(11)

Detailed Status

Completed62
unknown11
Recruiting6
Withdrawn6
Terminated6
Active, not recruiting4

Development Timeline

Analytics

Development Status

Total Trials
97
Active
10
Success Rate
91.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (3.2%)
Phase 128 (30.1%)
Phase 225 (26.9%)
Phase 319 (20.4%)
Phase 410 (10.8%)
N/A8 (8.6%)

Trials by Status

recruiting66%
withdrawn66%
active_not_recruiting44%
unknown1111%
not_yet_recruiting11%
completed6264%
terminated66%
enrolling_by_invitation11%

Recent Activity

Clinical Trials (97)

Showing 20 of 97 trialsScroll for more
NCT07309341Not Applicable

Effects of Isotretinoin on Smell

Recruiting
NCT06172296Phase 3

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Recruiting
NCT07481370Phase 2

Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm

Enrolling By Invitation
NCT01857934Phase 2

Therapy for Children With Advanced Stage Neuroblastoma

Completed
NCT03786783Phase 2

Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

Active Not Recruiting
NCT01711554Phase 1

Lenalidomide and Dinutuximab With or Without Isotretinoin in Treating Younger Patients With Refractory or Recurrent Neuroblastoma

Active Not Recruiting
NCT00026312Phase 3

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma

Completed
NCT06942039Early Phase 1

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

Recruiting
NCT03126916Phase 3

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Recruiting
NCT01175356Phase 1

Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin

Completed
NCT04385277Phase 2

Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)

Active Not Recruiting
NCT03033303Phase 2

A Study of the Effect of Hu3F8/GM-CSF Immunotherapy Plus Isotretinoin in Patients in First Remission of High-Risk Neuroblastoma

Completed
NCT06225570Early Phase 1

Weekly Isotretinoin vs Tetracycline for Moderate Acne

Recruiting
NCT07054398Not Applicable

Assessment of Serum Catestatin Level in Acne Vulgaris Patients

Recruiting
NCT00392327Phase 3

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET

Active Not Recruiting
NCT06873087Phase 4

Changes in PACAP, CGRP, and VIP Levels in Rosacea Patients on Systemic Isotretinoin and Their Association with Erythema

Completed
NCT03076021Phase 4

Effects of Isotretinoin on CYP2D6 Activity

Completed
NCT05869188Not Applicable

Effect of Systemic Isotretinoin on Serum Irisin Level in Acne Vulgaris Patients

Completed
NCT06698263Phase 4

13-cis Retinoic Acid (Isotretinoin) and Sperm Production

Not Yet Recruiting
NCT01969058Phase 2

Effect of Isotretinoin on Immune Activation Among HIV-1 Infected Subjects With Incomplete CD4+ T Cell Recovery

Completed

Drug Details

Intervention Type
DRUG
Total Trials
97