Success Metrics

Clinical Success Rate
79.1%

Based on 129 completed trials

Completion Rate
79%(129/163)
Active Trials
87(31%)
Results Posted
90%(116 trials)
Terminated
34(12%)

Phase Distribution

Ph phase_4
2
1%
Ph phase_1
108
38%
Ph phase_3
39
14%
Ph early_phase_1
2
1%
Ph phase_2
123
43%

Phase Distribution

110

Early Stage

123

Mid Stage

41

Late Stage

Phase Distribution274 total trials
Early Phase 1First-in-human
2(0.7%)
Phase 1Safety & dosage
108(39.4%)
Phase 2Efficacy & side effects
123(44.9%)
Phase 3Large-scale testing
39(14.2%)
Phase 4Post-market surveillance
2(0.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

71.3%

129 of 181 finished

Non-Completion Rate

28.7%

52 ended early

Currently Active

87

trials recruiting

Total Trials

284

all time

Status Distribution
Active(88)
Completed(129)
Terminated(52)
Other(15)

Detailed Status

Completed129
Active, not recruiting60
Terminated34
Recruiting27
Withdrawn18
unknown15

Development Timeline

Analytics

Development Status

Total Trials
284
Active
87
Success Rate
79.1%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (0.7%)
Phase 1108 (39.4%)
Phase 2123 (44.9%)
Phase 339 (14.2%)
Phase 42 (0.7%)

Trials by Status

unknown155%
withdrawn186%
active_not_recruiting6021%
recruiting2710%
not_yet_recruiting10%
completed12945%
terminated3412%

Recent Activity

Clinical Trials (284)

Showing 20 of 284 trialsScroll for more
NCT07082868Phase 1

A Study of Epcoritamab and Ibrutinib in People With Central Nervous System Lymphoma (CNSL)

Recruiting
NCT05283720Phase 2

A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma

Recruiting
NCT03506373Phase 2

Ibrutinib and Ixazomib Citrate in Treating Newly Diagnosed, Relapsed or Refractory Waldenstrom Macroglobulinemia

Terminated
NCT02443077Phase 3

Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma

Active Not Recruiting
NCT06649812Phase 2

Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

Recruiting
NCT01886872Phase 3

Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

Active Not Recruiting
NCT03737981Phase 3

Testing the Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

Active Not Recruiting
NCT03701282Phase 3

Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia

Active Not Recruiting
NCT02048813Phase 3

Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Active Not Recruiting
NCT04608318Phase 3

Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL)

Active Not Recruiting
NCT01849263Phase 2

Ibrutinib in Treating Patients With Relapsed or Refractory Follicular Lymphoma

Active Not Recruiting
NCT02581930Phase 2

Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

Active Not Recruiting
NCT03964090Phase 2

Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, and Rituximab (TEDDI-R) in Aggressive B-cell Lymphomas With Secondary Involvement of the Central Nervous System (CNS)

Active Not Recruiting
NCT04739813Phase 1

Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid in Combination With Polatuzumab (ViPOR-P) in Relapsed/Refractory B-cell Lymphoma

Recruiting
NCT06136559Phase 3

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Recruiting
NCT03479268Phase 1

Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma

Active Not Recruiting
NCT05254743Phase 3

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Recruiting
NCT03223610Phase 1

Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (ViPOR) in Relapsed/Refractory B-cell Lymphoma

Recruiting
NCT02436707Phase 2

Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma

Active Not Recruiting
NCT03960840Phase 1

Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
284