Success Metrics

Clinical Success Rate
95.5%

Based on 21 completed trials

Completion Rate
95%(21/22)
Active Trials
0(0%)
Results Posted
43%(9 trials)
Terminated
1(4%)

Phase Distribution

Ph phase_3
1
4%
Ph early_phase_1
1
4%
Ph phase_1
12
52%
Ph phase_2
9
39%

Phase Distribution

13

Early Stage

9

Mid Stage

1

Late Stage

Phase Distribution23 total trials
Early Phase 1First-in-human
1(4.3%)
Phase 1Safety & dosage
12(52.2%)
Phase 2Efficacy & side effects
9(39.1%)
Phase 3Large-scale testing
1(4.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

91.3%

21 of 23 finished

Non-Completion Rate

8.7%

2 ended early

Currently Active

0

trials recruiting

Total Trials

23

all time

Status Distribution
Completed(21)
Terminated(2)

Detailed Status

Completed21
Terminated1
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
23
Active
0
Success Rate
95.5%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (4.3%)
Phase 112 (52.2%)
Phase 29 (39.1%)
Phase 31 (4.3%)

Trials by Status

completed2191%
terminated14%
withdrawn14%

Recent Activity

Clinical Trials (23)

Showing 20 of 23 trialsScroll for more
NCT01155453Phase 1

A Study to Investigate Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of BKM120 Plus GSK1120212 in Selected Advanced Solid Tumor Patients

Completed
NCT01467310Early Phase 1

Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212

Completed
NCT01072175Phase 2

Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212

Completed
NCT01231594Phase 1

A Rollover Study to Provide Continued Treatment With GSK2118436 to Subjects With BRAF Mutation-Positive Tumors

Completed
NCT01376310Phase 2

GSK1120212 Rollover Study

Terminated
NCT01438554Phase 1

Phase 1 Study of Pazopanib With GSK1120212 in Advanced Solid Tumors, Enriched With Patients With Differentiated Thyroid Cancer, Soft-tissue Sarcoma, and Cholangiocarcinoma

Completed
NCT01245062Phase 3

GSK1120212 vs Chemotherapy in Advanced or Metastatic BRAF V600E/K Mutation-positive Melanoma

Completed
NCT01328106Phase 2

Efficacy and Safety Study of GSK1120212, a MEK Inhibitor, in Subjects With Uveal Melanoma

Withdrawn
NCT01658553Phase 1

A Study to Look at the Electrical Activity of the Heart in Subjects With Solid Tumor Cancers, Before and After Receiving the Study Treatment, GSK1120212

Completed
NCT01416337Phase 1

Absolute Bioavialability of GSK1120212

Completed
NCT01428427Phase 1

Combination Study of GSK1120212 With Gemcitabine in Subjects With Solid Tumors

Completed
NCT01138085Phase 1

Safety, Pharmacokinetics (PK) of AKT and MEK Combination

Completed
NCT01387204Phase 1

Study to Investigate the Absorption, Distribution, Metabolism and Elimination of [14C]GSK1120212

Completed
NCT01476137Phase 1

A Study of the Safety and Activity of the MEK Inhibitor Given Together With the AKT Inhibitor to Patients With Multiple Myeloma or Solid Tumor Cancers

Completed
NCT01324258Phase 1

Trial of GSK1120212 and GSK1120212 in Combination With GEM in Japanese Subjects With Solid Tumors

Completed
NCT01371487Phase 1

GSK1120212 Food-effect Study

Completed
NCT00687622Phase 1

Open-label Study to Investigate the Safety, PK, and Pharmacodynamics of GSK1120212 in Subjects With Solid Tumors or Lymphoma

Completed
NCT01553851Phase 2

GSK1120212 in Surgically Resectable Oral Cavity Squamous Cell Cancer

Completed
NCT01619774Phase 2

An Open-Label Phase II Study of the Combination of GSK2118436 and GSK1120212 in Patients With Metastatic Melanoma Which is Refractory or Resistant to BRAF Inhibitor

Completed
NCT01362296Phase 2

An Open-label Study of GSK1120212 Compared With Docetaxel in Stage IV KRAS-mutant Non-small Cell Lung Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
23