Success Metrics

Clinical Success Rate
90.0%

Based on 18 completed trials

Completion Rate
90%(18/20)
Active Trials
1(5%)
Results Posted
94%(17 trials)
Terminated
2(10%)

Phase Distribution

Ph phase_3
4
19%
Ph early_phase_1
1
5%
Ph phase_2
11
52%
Ph phase_1
5
24%

Phase Distribution

6

Early Stage

11

Mid Stage

4

Late Stage

Phase Distribution21 total trials
Early Phase 1First-in-human
1(4.8%)
Phase 1Safety & dosage
5(23.8%)
Phase 2Efficacy & side effects
11(52.4%)
Phase 3Large-scale testing
4(19.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

90.0%

18 of 20 finished

Non-Completion Rate

10.0%

2 ended early

Currently Active

1

trials recruiting

Total Trials

21

all time

Status Distribution
Active(1)
Completed(18)
Terminated(2)

Detailed Status

Completed18
Terminated2
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
21
Active
1
Success Rate
90.0%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (4.8%)
Phase 15 (23.8%)
Phase 211 (52.4%)
Phase 34 (19.0%)

Trials by Status

recruiting15%
completed1886%
terminated210%

Recent Activity

Clinical Trials (21)

Showing 20 of 21 trialsScroll for more
NCT04193176Phase 3

Efficacy and Safety of Gefapixant (MK-7264) in Women With Chronic Cough and Stress Urinary Incontinence (MK-7264-042)

Completed
NCT03654326Phase 2

A Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Women With Endometriosis-Related Pain (MK-7264-034)

Completed
NCT03882801Phase 1

Safety and Tolerability of Gefapixant (MK-7264) in Participants With Obstructive Sleep Apnea (MK-7264-039)

Completed
NCT05813223Early Phase 1

Effect of Gefapixant on Cough-related Brain Activity in Patients With Chronic Cough

Recruiting
NCT04193202Phase 3

Efficacy and Safety of Gefapixant (MK-7264) in Adult Participants With Recent Onset Chronic Cough (MK-7264-043)

Completed
NCT03108924Phase 1

The Pharmacokinetics of Gefapixant (MK-7264) in Participants With Renal Insufficiency (MK-7264-026)

Completed
NCT02229877Phase 1

A Study to Assess the Effect of Intragastric pH and Fasting on the Pharmacokinetics of Gefapixant (AF-219/MK-7264)

Completed
NCT02492776Phase 1

A Multiple-Dose Pharmacokinetics Study of Two Gefapixant (AF-219/MK-7264) Formulations

Completed
NCT03696108Phase 3

A Study of Gefapixant (MK-7264) in Japanese Adult Participants With Refractory or Unexplained Chronic Cough (MK-7264-038)

Completed
NCT03449134Phase 3

A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027)

Completed
NCT02502097Phase 2

A Study of Gefapixant (AF-219/MK-7264) in Participants With Idiopathic Pulmonary Fibrosis (IPF) With Persistent Cough (MK-7264-016)

Completed
NCT02397460Phase 2

Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity (MK-7264-015)

Completed
NCT01432730Phase 2

A Study to Assess the Efficacy of Gefapixant (MK-7264/AF-219), in Participants With Chronic Cough (MK-7264-006)

Completed
NCT02349425Phase 2

A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010)

Completed
NCT01569438Phase 2

The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Participants With Interstitial Cystitis /Bladder Pain Syndrome (MK-7264-005)

Terminated
NCT02612610Phase 2

A 12-Week Study in Participants With Refractory Chronic Cough (MK-7264-012)

Completed
NCT03569033Phase 2

Study of Gefapixant (MK-7264) in Acute Cough for Participants With Induced Viral Upper Respiratory Tract Infection (URTI) (MK-7264-013)

Terminated
NCT02612623Phase 2

An 8-Week Refractory Chronic Cough Study (MK-7264-021)

Completed
NCT01554579Phase 2

A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee

Completed
NCT02477709Phase 2

A Study to Assess the Tolerability of a Single Dose of Gefapixant (AF-219/MK-7264) in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
21