Success Metrics

Clinical Success Rate
37.5%

Based on 6 completed trials

Completion Rate
38%(6/16)
Active Trials
0(0%)
Results Posted
133%(8 trials)
Terminated
10(56%)

Phase Distribution

Ph phase_2
9
50%
Ph phase_1
9
50%

Phase Distribution

9

Early Stage

9

Mid Stage

0

Late Stage

Phase Distribution18 total trials
Phase 1Safety & dosage
9(50.0%)
Phase 2Efficacy & side effects
9(50.0%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

33.3%

6 of 18 finished

Non-Completion Rate

66.7%

12 ended early

Currently Active

0

trials recruiting

Total Trials

18

all time

Status Distribution
Completed(6)
Terminated(12)

Detailed Status

Terminated10
Completed6
Withdrawn2

Development Timeline

Analytics

Development Status

Total Trials
18
Active
0
Success Rate
37.5%
Most Advanced
Phase 2

Trials by Phase

Phase 19 (50.0%)
Phase 29 (50.0%)

Trials by Status

terminated1056%
completed633%
withdrawn211%

Recent Activity

Clinical Trials (18)

Showing 18 of 18 trials
NCT01200810Phase 2

Bicalutamide and RO4929097 in Treating Patients With Previously Treated Prostate Cancer

Terminated
NCT01122901Phase 2

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma

Terminated
NCT01151449Phase 2

Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced, Metastatic, or Recurrent Triple Negative Invasive Breast Cancer

Terminated
NCT01270438Phase 2

Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients With Metastatic Colorectal Cancer

Withdrawn
NCT01120275Phase 2

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma

Terminated
NCT01189240Phase 1

RO4929097and Bevacizumab in Treating Patients With Progressive or Recurrent Malignant Glioma

Terminated
NCT01193868Phase 2

RO4929097 in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Recently Completed Treatment With Front-Line Chemotherapy

Terminated
NCT01232829Phase 2

Gamma Secretase Inhibitor RO4929097 in Previously Treated Metastatic Pancreas Cancer

Completed
NCT01158274Phase 1

RO4929097 and Capecitabine in Treating Patients With Refractory Solid Tumors

Completed
NCT01088763Phase 1

Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia

Terminated
NCT01198184Phase 1

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 and Temsirolimus in Treating Patients With Advanced Solid Tumors

Completed
NCT01116687Phase 2

RO4929097 in Treating Patients With Metastatic Colorectal Cancer

Completed
NCT01096355Phase 1

Gamma-Secretase Inhibitor RO4929097 in Treating Patients With Metastatic or Unresectable Solid Malignancies

Completed
NCT01145456Phase 1

Gamma-Secretase Inhibitor RO4929097 and Gemcitabine Hydrochloride in Treating Patients With Advanced Solid Tumors

Completed
NCT01192763Phase 1

RO4929097 Before Surgery in Treating Patients With Pancreatic Cancer

Terminated
NCT01208441Phase 1

RO4929097 and Letrozole in Treating Post-Menopausal Women With Hormone Receptor-Positive Stage II or Stage III Breast Cancer

Terminated
NCT01269411Phase 1

RO4929097 in Treating Patients With Recurrent Invasive Gliomas

Terminated
NCT01216787Phase 2

RO4929097 in Treating Patients With Stage IIIB, Stage IIIC, or Stage IV Melanoma That Can Be Removed by Surgery

Withdrawn

All 18 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
18