Success Metrics

Clinical Success Rate
73.3%

Based on 132 completed trials

Completion Rate
73%(132/180)
Active Trials
121(34%)
Results Posted
95%(126 trials)
Terminated
48(14%)

Phase Distribution

Ph not_applicable
3
1%
Ph phase_4
6
2%
Ph early_phase_1
2
1%
Ph phase_3
57
16%
Ph phase_2
161
46%
Ph phase_1
110
31%

Phase Distribution

112

Early Stage

161

Mid Stage

63

Late Stage

Phase Distribution339 total trials
Early Phase 1First-in-human
2(0.6%)
Phase 1Safety & dosage
110(32.4%)
Phase 2Efficacy & side effects
161(47.5%)
Phase 3Large-scale testing
57(16.8%)
Phase 4Post-market surveillance
6(1.8%)
N/ANon-phased studies
3(0.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

68.0%

132 of 194 finished

Non-Completion Rate

32.0%

62 ended early

Currently Active

121

trials recruiting

Total Trials

353

all time

Status Distribution
Active(130)
Completed(132)
Terminated(62)
Other(29)

Detailed Status

Completed132
Recruiting67
Active, not recruiting54
Terminated48
unknown29
Withdrawn14

Development Timeline

Analytics

Development Status

Total Trials
353
Active
121
Success Rate
73.3%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (0.6%)
Phase 1110 (32.4%)
Phase 2161 (47.5%)
Phase 357 (16.8%)
Phase 46 (1.8%)
N/A3 (0.9%)

Trials by Status

active_not_recruiting5415%
recruiting6719%
terminated4814%
unknown298%
withdrawn144%
completed13237%
not_yet_recruiting93%

Recent Activity

Clinical Trials (353)

Showing 20 of 353 trialsScroll for more
NCT05646862Phase 3

A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy

Active Not Recruiting
NCT07062965Phase 3

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

Recruiting
NCT07570966Phase 1

Study of ERW316 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

Not Yet Recruiting
NCT03179904Phase 2

TVB-2640 and Trastuzumab With Paclitaxel or Endocrine Therapy for Treatment of HER2 Positive Metastatic Breast Cancer

Active Not Recruiting
NCT07287917Phase 1

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

Recruiting
NCT06065748Phase 3

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Recruiting
NCT06998407Phase 1

ORION-1: Study of AVZO-023 as a Single Agent and in Combination With AVZO-021, and/or Endocrine Therapy in Advanced Solid Tumors

Recruiting
NCT05564377Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting
NCT05870579Phase 1

[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer

Recruiting
NCT05608252Phase 1

VS-6766+Abema+Fulv in Met HR+/HER- BC

Recruiting
NCT07558733Phase 1

Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer

Recruiting
NCT04305496Phase 3

Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer

Active Not Recruiting
NCT05306340Phase 3

A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With the Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)

Active Not Recruiting
NCT03939897Phase 1

Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer

Active Not Recruiting
NCT03633331Phase 2

Palbociclib and Letrozole or Fulvestrant in Treating Patients With Estrogen Receptor Positive, HER2 Negative Metastatic Breast Cancer

Completed
NCT07174336Phase 3

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Recruiting
NCT06726148Phase 1

Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

Recruiting
NCT06428396Phase 2

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

Recruiting
NCT05768139Phase 1

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

Recruiting
NCT05683418Phase 1

A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
353