Success Metrics

Clinical Success Rate
78.0%

Based on 224 completed trials

Completion Rate
78%(224/287)
Active Trials
48(13%)
Results Posted
67%(149 trials)
Terminated
63(17%)

Phase Distribution

Ph not_applicable
19
5%
Ph early_phase_1
5
1%
Ph phase_1
138
36%
Ph phase_2
198
52%
Ph phase_3
19
5%

Phase Distribution

143

Early Stage

198

Mid Stage

19

Late Stage

Phase Distribution379 total trials
Early Phase 1First-in-human
5(1.3%)
Phase 1Safety & dosage
138(36.4%)
Phase 2Efficacy & side effects
198(52.2%)
Phase 3Large-scale testing
19(5.0%)
N/ANon-phased studies
19(5.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

72.5%

224 of 309 finished

Non-Completion Rate

27.5%

85 ended early

Currently Active

48

trials recruiting

Total Trials

381

all time

Status Distribution
Active(51)
Completed(224)
Terminated(85)
Other(21)

Detailed Status

Completed224
Terminated63
Recruiting24
Active, not recruiting24
Withdrawn22
unknown16

Development Timeline

Analytics

Development Status

Total Trials
381
Active
48
Success Rate
78.0%
Most Advanced
Phase 3

Trials by Phase

Early Phase 15 (1.3%)
Phase 1138 (36.4%)
Phase 2198 (52.2%)
Phase 319 (5.0%)
N/A19 (5.0%)

Trials by Status

unknown164%
not_yet_recruiting31%
recruiting246%
withdrawn226%
completed22459%
active_not_recruiting246%
terminated6317%
suspended51%

Recent Activity

Clinical Trials (381)

Showing 20 of 381 trialsScroll for more
NCT06904066Phase 1

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

Recruiting
NCT05495464Early Phase 1

A Pilot "Window-3" Study of Acalabrutinib Plus Rituximab Followed by Brexucabtagene Autoleucel Therapy in Patients With Previously Untreated High-risk Mantle Cell Lymphoma

Active Not Recruiting
NCT04708054Phase 2

Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS

Recruiting
NCT05092451Phase 1

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

Recruiting
NCT06066359Phase 1

Ph I/II Trial of Cord Blood-derived NK Cells With NY-ESO-1 TCR/IL-15 for R/R Myeloma

Recruiting
NCT02861417Phase 2

Busulfan, Fludarabine Phosphate, and Post-Transplant Cyclophosphamide in Treating Patients With Blood Cancer Undergoing Donor Stem Cell Transplant

Active Not Recruiting
NCT04539366Phase 1

Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, GD2-CAR PERSIST Trial

Suspended
NCT06358430Phase 1

Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD)

Active Not Recruiting
NCT02048813Phase 3

Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Active Not Recruiting
NCT06871410Phase 1

Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Recruiting
NCT05703854Phase 1

Study of CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Advanced Renal Cell Carcinoma, Mesothelioma and Osteosarcoma

Suspended
NCT05110742Phase 1

Phase I/II Study of CD5 CAR Engineered IL15-Transduced Cord Blood-Derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapsed/Refractory Hematological Malignances

Recruiting
NCT02727803Phase 2

Personalized NK Cell Therapy in CBT

Recruiting
NCT05470283Phase 1

Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma

Active Not Recruiting
NCT06083883Phase 1

Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1

Recruiting
NCT05955261Phase 2

A Study of Venetoclax in Combination With Conventional Chemotherapy in Pediatric Patients With Acute Myeloid Leukemia

Suspended
NCT06013423Phase 2

Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases

Recruiting
NCT05052528Phase 1

Fludarabine and Cyclophosphamide With or Without Rituximab Before CD19 Chimeric Antigen Receptor T Cells for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Recruiting
NCT05761171Phase 2

A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Active Not Recruiting
NCT05400122Phase 1

Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer

Suspended

Drug Details

Intervention Type
DRUG
Total Trials
381