Success Metrics

Clinical Success Rate
78.3%

Based on 224 completed trials

Completion Rate
78%(224/286)
Active Trials
50(13%)
Results Posted
66%(148 trials)
Terminated
62(16%)

Phase Distribution

Ph phase_2
196
52%
Ph phase_3
19
5%
Ph not_applicable
19
5%
Ph phase_1
138
36%
Ph early_phase_1
5
1%

Phase Distribution

143

Early Stage

196

Mid Stage

19

Late Stage

Phase Distribution377 total trials
Early Phase 1First-in-human
5(1.3%)
Phase 1Safety & dosage
138(36.6%)
Phase 2Efficacy & side effects
196(52.0%)
Phase 3Large-scale testing
19(5.0%)
N/ANon-phased studies
19(5.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

72.7%

224 of 308 finished

Non-Completion Rate

27.3%

84 ended early

Currently Active

50

trials recruiting

Total Trials

379

all time

Status Distribution
Active(51)
Completed(224)
Terminated(84)
Other(20)

Detailed Status

Completed224
Terminated62
Recruiting26
Active, not recruiting24
Withdrawn22
unknown16

Development Timeline

Analytics

Development Status

Total Trials
379
Active
50
Success Rate
78.3%
Most Advanced
Phase 3

Trials by Phase

Early Phase 15 (1.3%)
Phase 1138 (36.6%)
Phase 2196 (52.0%)
Phase 319 (5.0%)
N/A19 (5.0%)

Trials by Status

terminated6216%
not_yet_recruiting10%
suspended41%
withdrawn226%
recruiting267%
completed22459%
active_not_recruiting246%
unknown164%

Recent Activity

Clinical Trials (379)

Showing 20 of 379 trialsScroll for more
NCT06904066Phase 1

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

Recruiting
NCT05092451Phase 1

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

Recruiting
NCT06043323Phase 2

A Phase II Study of Axicabtagene Ciloleucel, an Anti-CD19 Chimeric Antigen Receptor (CAR) Tcell Therapy, in Combination With Radiotherapy (RT) in Relapsed/Refractory Follicular Lymphoma

Recruiting
NCT02727803Phase 2

Personalized NK Cell Therapy in CBT

Recruiting
NCT04539366Phase 1

Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, The GD2-CAR PERSIST Trial

Suspended
NCT03670966Phase 1

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

Recruiting
NCT02048813Phase 3

Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Active Not Recruiting
NCT01231412Phase 3

Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant

Completed
NCT05955261Phase 2

A Study of Venetoclax in Combination With Conventional Chemotherapy in Pediatric Patients With Acute Myeloid Leukemia

Suspended
NCT05761171Phase 2

A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Active Not Recruiting
NCT06083883Phase 1

Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1

Recruiting
NCT05470283Phase 1

Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma

Active Not Recruiting
NCT06066424Phase 1

Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA)

Recruiting
NCT01955460Phase 1

Genetically Modified T-Cells Followed by Aldesleukin in Treating Patients With Stage III-IV Melanoma

Active Not Recruiting
NCT06434363Phase 1

Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders

Recruiting
NCT02250937Phase 2

Venetoclax and Sequential Busulfan, Cladribine, and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

Active Not Recruiting
NCT03192397Phase 1

Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

Active Not Recruiting
NCT00801489Phase 2

Fludarabine Phosphate, Cytarabine, Filgrastim-sndz, Gemtuzumab Ozogamicin, and Idarubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Recruiting
NCT02333162Phase 1

Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant

Suspended
NCT02251821Phase 2

JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis

Completed

Drug Details

Intervention Type
DRUG
Total Trials
379