Success Metrics

Clinical Success Rate
100.0%

Based on 11 completed trials

Completion Rate
100%(11/11)
Active Trials
2(13%)
Results Posted
55%(6 trials)

Phase Distribution

Ph phase_4
3
19%
Ph phase_3
5
31%
Ph early_phase_1
1
6%
Ph phase_2
2
13%
Ph phase_1
5
31%

Phase Distribution

6

Early Stage

2

Mid Stage

8

Late Stage

Phase Distribution16 total trials
Early Phase 1First-in-human
1(6.3%)
Phase 1Safety & dosage
5(31.3%)
Phase 2Efficacy & side effects
2(12.5%)
Phase 3Large-scale testing
5(31.3%)
Phase 4Post-market surveillance
3(18.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

91.7%

11 of 12 finished

Non-Completion Rate

8.3%

1 ended early

Currently Active

2

trials recruiting

Total Trials

16

all time

Status Distribution
Active(2)
Completed(11)
Terminated(1)
Other(2)

Detailed Status

Completed11
unknown2
Withdrawn1
Recruiting1
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
16
Active
2
Success Rate
100.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (6.3%)
Phase 15 (31.3%)
Phase 22 (12.5%)
Phase 35 (31.3%)
Phase 43 (18.8%)

Trials by Status

completed1169%
unknown213%
withdrawn16%
recruiting16%
active_not_recruiting16%

Recent Activity

Clinical Trials (16)

Showing 16 of 16 trials
NCT07547878Phase 4

Simultaneous Starting of the 4 Guideline Directed CKD Therapies (RAPID-CKD)

Active Not Recruiting
NCT04438213Phase 2

Ertugliflozin in Chronic Heart Failure

Recruiting
NCT03416270Phase 2

ERtugliflozin triAl in DIabetes With Preserved or Reduced ejeCtion FrAcTion mEchanistic Evaluation in Heart Failure

Completed
NCT04231331Phase 3

Ertugliflozin for Functional Mitral Regurgitation

Completed
NCT04167761Early Phase 1

Ertugliflozin: Cardioprotective Effects on Epicardial Fat

Completed
NCT03717194Phase 3

Effect of Ertugliflozin on Cardiac Function in Diabetes

Completed
NCT05152940Phase 4

ERTU-SODIUM: Study on the Effects of Ertugliflozin on Sodium Storage, Interstitial Volume, and Plasma Volume in HFrEF

Unknown
NCT01986881Phase 3

Cardiovascular Outcomes Following Ertugliflozin Treatment in Type 2 Diabetes Mellitus Participants With Vascular Disease, The VERTIS CV Study (MK-8835-004)

Completed
NCT04490681Phase 3

Validation of ERTugliflozin for Inhibiting Cardiac Fibrosis Using Cardiac MRI and Laboratory Parameters in Korean Heart Failure Patients With Nonischemic Cardiomyopathy(VERTICAL)

Unknown
NCT01018823Phase 1

A Multiple Dose Study Of Ertugliflozin (PF-04971729, MK-8835) In Otherwise Healthy Overweight And Obese Volunteers (MK-8835-037)

Completed
NCT00989079Phase 1

A Single Escalating Dose Study Of Ertugliflozin (PF-04971729, MK-8835) Under Fed and Fasted Conditons In Healthy Volunteers (MK-8835-036)

Completed
NCT03640221Phase 4

Ertugliflozin Versus Hydrochlorothiazide in Reducing Sympathetic Neural Overactivity in Patients With Hypertension and Recently-diagnosed Type 2 Diabetes.

Withdrawn
NCT01948986Phase 1

Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Ertugliflozin in Participants With Type 2 Diabetes Mellitus (MK-8835-009)

Completed
NCT02226003Phase 3

Efficacy and Safety of Ertugliflozin (MK-8835/PF-04971729) With Sitagliptin in the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Diet and Exercise (MK-8835-017)

Completed
NCT01223339Phase 1

Evaluation of Pharmacokinetics, Safety, And Tolerability Of Ertugliflozin (PF-04971729, MK-8835) In Japanese And Western Healthy Participants (MK-8835-041)

Completed
NCT01127308Phase 1

A Radiolabeled Mass Balance Study of [14C]-Ertugliflozin (PF04971729, MK-8835) In Healthy Male Participants (MK-8835-038)

Completed

All 16 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
16