Success Metrics

Clinical Success Rate
83.0%

Based on 73 completed trials

Completion Rate
83%(73/88)
Active Trials
8(6%)
Results Posted
40%(29 trials)
Terminated
15(11%)

Phase Distribution

Ph phase_4
50
36%
Ph phase_3
21
15%
Ph phase_2
28
20%
Ph not_applicable
14
10%
Ph phase_1
14
10%

Phase Distribution

14

Early Stage

28

Mid Stage

71

Late Stage

Phase Distribution127 total trials
Phase 1Safety & dosage
14(11.0%)
Phase 2Efficacy & side effects
28(22.0%)
Phase 3Large-scale testing
21(16.5%)
Phase 4Post-market surveillance
50(39.4%)
N/ANon-phased studies
14(11.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

81.1%

73 of 90 finished

Non-Completion Rate

18.9%

17 ended early

Currently Active

8

trials recruiting

Total Trials

140

all time

Status Distribution
Active(11)
Completed(73)
Terminated(17)
Other(39)

Detailed Status

Completed73
unknown39
Terminated15
Recruiting5
Active, not recruiting3
Not yet recruiting3

Development Timeline

Analytics

Development Status

Total Trials
140
Active
8
Success Rate
83.0%
Most Advanced
Phase 4

Trials by Phase

Phase 114 (11.0%)
Phase 228 (22.0%)
Phase 321 (16.5%)
Phase 450 (39.4%)
N/A14 (11.0%)

Trials by Status

active_not_recruiting32%
unknown3928%
not_yet_recruiting32%
recruiting54%
withdrawn21%
completed7352%
terminated1511%

Recent Activity

Clinical Trials (140)

Showing 20 of 140 trialsScroll for more
NCT04431245

Stopping Antiviral Treatment in Chronic Hepatitis B

Active Not Recruiting
NCT07345624Phase 4

Entecavir With or Without Pegylated Interferon α-2b in Children Aged 3-6 Years With Immune-Tolerant Chronic Hepatitis B

Not Yet Recruiting
NCT07345611Phase 4

Entecavir With or Without Pegylated Interferon α-2b in Children Aged 3-6 Years With Immune-Active Chronic Hepatitis B

Not Yet Recruiting
NCT02065336Phase 2

A Multicenter Study to Determine the Depth and Duration of Hepatitis B Surface Antigen (HBsAg) Reduction After Single or Multiple Doses of ARC-520, in Combination With Entecavir in Patients With Chronic Hepatitis B Virus (HBV) Infection

Terminated
NCT02738008Phase 2

Extension Study of the Safety and Efficacy of Multi-dose Intravenous ARC-520 in Patients With Chronic Hepatitis B (HBV) Infection

Terminated
NCT02604199Phase 2

A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Negative, Chronic Hepatitis B Virus (HBV) Infection

Terminated
NCT02577029Phase 2

Study of ARC-520 With or Without Other Drugs Used in the Treatment of Chronic Chronic Hepatitis B Virus (HBV)

Terminated
NCT02604212Phase 2

A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Positive, Chronic Hepatitis B Virus Infection

Terminated
NCT02797522Phase 1

A Study of ARC-521 Injection in Normal Adult Volunteers and Patients With Chronic Hepatitis B (CHB)

Terminated
NCT07295873Phase 1

Drug-Drug Interaction Study Between Hydronidone and Entecavir, Tenofovir Disoproxil Fumarate, Tenofovir Alafenamide, and Tenofovir Amibufenamide

Not Yet Recruiting
NCT04536337Phase 1

A Study of ALG-000184 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single and Multiple Doses in Healthy Volunteers and CHB Subjects

Completed
NCT07189377Phase 4

Combined Light, ExVivo, and Antivirals for Recipients of Lungs From HBV Donors

Recruiting
NCT02452528Phase 2

Study of ARC-520 in Participants With Hepatitis B Virus e Antigen (HBeAg) Positive Chronic Hepatitis B Virus

Terminated
NCT06966232Phase 3

Prophylactic or Preemptive Entecavir in Patients With Gastrointestinal Cancer Who Are Inactive Hepatitis B Carriers

Recruiting
NCT05275023Phase 2

An Efficacy and Safety Study of a Combination of JNJ-73763989, Nucleos(t)Ide Analogs (NA), and a Programmed Cell Death Protein Receptor-1 (PD-1) Inhibitor in Chronic Hepatitis B Participants

Completed
NCT03933384Phase 4

Tenofovir Alafenamide Versus Entecavir for the Treatment of Chronic Hepatitis B

Recruiting
NCT05017116Phase 1

A Single and Repeated Dose Escalation of RBD1016 in Subjects with Chronic Hepatitis B Virus (HBV) Infection

Completed
NCT03920618Not Applicable

Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF

Recruiting
NCT03887702Phase 3

Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus Infection Receiving Anti-Cancer Therapy for Solid Tumors

Terminated
NCT05453435Phase 2

Entecavir Prophylaxis for Hepatitis B Reactivation for CD20 Positive B-cell Lymphoma Patients With Resolved Hepatitis B (Negative Hepatitis B Surface Antigen, Positive Hepatitis B Core Antibody)

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
140