Success Metrics

Clinical Success Rate
84.6%

Based on 11 completed trials

Completion Rate
85%(11/13)
Active Trials
13(46%)
Results Posted
27%(3 trials)
Terminated
2(7%)

Phase Distribution

Ph phase_2
12
43%
Ph phase_1
16
57%

Phase Distribution

16

Early Stage

12

Mid Stage

0

Late Stage

Phase Distribution28 total trials
Phase 1Safety & dosage
16(57.1%)
Phase 2Efficacy & side effects
12(42.9%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

73.3%

11 of 15 finished

Non-Completion Rate

26.7%

4 ended early

Currently Active

13

trials recruiting

Total Trials

28

all time

Status Distribution
Active(13)
Completed(11)
Terminated(4)

Detailed Status

Recruiting12
Completed11
Terminated2
Withdrawn2
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
28
Active
13
Success Rate
84.6%
Most Advanced
Phase 2

Trials by Phase

Phase 116 (57.1%)
Phase 212 (42.9%)

Trials by Status

completed1139%
terminated27%
recruiting1243%
withdrawn27%
active_not_recruiting14%

Recent Activity

Clinical Trials (28)

Showing 20 of 28 trialsScroll for more
NCT06672146Phase 2

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

Recruiting
NCT05564390Phase 2

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Recruiting
NCT06176989Phase 2

Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors

Recruiting
NCT06577441Phase 2

Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

Recruiting
NCT05756777Phase 1

A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML)

Recruiting
NCT03383575Phase 2

Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome

Recruiting
NCT06240754Phase 2

Enasidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH2A Decentralized Trial

Recruiting
NCT05102370Phase 1

A Study of Enasidenib in People With Clonal Cytopenia of Undetermined Significance

Completed
NCT02813135Phase 1

European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors

Recruiting
NCT05010772Phase 1

Decitabine Alone or in Combination With Venetoclax, Gilteritinib, Enasidenib, or Ivosidenib as Maintenance Therapy for the Treatment of Acute Myeloid Leukemia in Remission

Recruiting
NCT04203316Phase 2

Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With an IDH2 Mutation

Active Not Recruiting
NCT06756308Phase 2

A Study of Enasidenib in People With T-Cell Lymphoma

Recruiting
NCT04774393Phase 1

Decitabine/Cedazuridine and Venetoclax in Combination With Ivosidenib or Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Recruiting
NCT03515512Phase 1

IDH2 Inhibition Using Enasidenib as Maintenance Therapy for IDH2-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation

Completed
NCT05401097Phase 2

IDH Targeted/Non- Targeted vs Non-targeted/IDH-targeted Approaches in the Treatment of Newly Diagnosed IDH Mutated AML Patients Not Candidates for Intensive Induction Therapy (I- DATA Study)

Recruiting
NCT04281498Phase 2

Combined Ruxolitinib and Enasidenib in Patients With Accelerated/Blast-phase Myeloproliferative Neoplasm or Chronic-phase Myelofibrosis With an IDH2 Mutation

Completed
NCT01915498Phase 1

Phase 1/2 Study of Enasidenib (AG-221) in Adults With Advanced Hematologic Malignancies With an Isocitrate Dehydrogenase Isoform 2 (IDH2) Mutation

Completed
NCT04522895Phase 2

IDH2-Post-Allo-Trial for Patients with IDH2-mut Myeloid Neoplasms After Allo-SCT

Completed
NCT04955938Phase 1

A Study of Fedratinib With IDH Inhibition in Advanced-Phase, IDH-Mutated Ph-Negative Myeloproliferative Neoplasms

Withdrawn
NCT04573582Phase 1

Pharmacokinetics of Enasidenib (CC-90007) in Participants With Mild, Moderate and Severe Hepatic Impairment

Completed

Drug Details

Intervention Type
DRUG
Total Trials
28