Success Metrics

Clinical Success Rate
100.0%

Based on 14 completed trials

Completion Rate
100%(14/14)
Active Trials
2(11%)
Results Posted
43%(6 trials)

Phase Distribution

Ph early_phase_1
1
5%
Ph phase_1
1
5%
Ph phase_3
6
32%
Ph phase_2
11
58%

Phase Distribution

2

Early Stage

11

Mid Stage

6

Late Stage

Phase Distribution19 total trials
Early Phase 1First-in-human
1(5.3%)
Phase 1Safety & dosage
1(5.3%)
Phase 2Efficacy & side effects
11(57.9%)
Phase 3Large-scale testing
6(31.6%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

100.0%

14 of 14 finished

Non-Completion Rate

0.0%

0 ended early

Currently Active

2

trials recruiting

Total Trials

19

all time

Status Distribution
Active(4)
Completed(14)
Other(1)

Detailed Status

Completed14
Not yet recruiting2
Recruiting2
unknown1

Development Timeline

Analytics

Development Status

Total Trials
19
Active
2
Success Rate
100.0%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (5.3%)
Phase 11 (5.3%)
Phase 211 (57.9%)
Phase 36 (31.6%)

Trials by Status

not_yet_recruiting211%
completed1474%
unknown15%
recruiting211%

Recent Activity

Clinical Trials (19)

Showing 19 of 19 trials
NCT07468136Phase 1

Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas

Not Yet Recruiting
NCT04301843Phase 2

Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma

Recruiting
NCT07321912Phase 2

Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

Not Yet Recruiting
NCT05717153Early Phase 1

Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma

Recruiting
NCT02794428Phase 2

Chemoprevention of Gastric Carcinogenesis

Completed
NCT02796261Phase 3

Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients

Unknown
NCT01483144Phase 3

Trial of Eflornithine Plus Sulindac in Patients With Familial Adenomatous Polyposis (FAP)

Completed
NCT00033371Phase 2

Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous Polyposis

Completed
NCT00005884Phase 3

Eflornithine to Prevent Skin Cancer in Patients With Previously Treated Early Stage Skin Cancer

Completed
NCT00983580Phase 2

Acetylsalicylic Acid and Eflornithine in Treating Patients at High Risk for Colorectal Cancer

Completed
NCT00006079Phase 2

Eflornithine To Prevent Cervical Cancer in Patients With Cervical Intraepithelial Neoplasia

Completed
NCT00021294Phase 2

Eflornithine With or Without Triamcinolone in Preventing Nonmelanoma Skin Cancer in Patients With Actinic Keratosis

Completed
NCT00006101Phase 2

Eflornithine in Treating Patients At High Risk of Developing Prostate Cancer

Completed
NCT01685827Phase 2

Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2

Completed
NCT00146627Phase 3

Efficacy - Safety of Eflornithine-Nifurtimox Combination Versus Eflornithine to Treat Human African Trypanosomiasis

Completed
NCT00118365Phase 3

Eflornithine and Sulindac in Preventing Colorectal Cancer in Patients With Colon Polyps

Completed
NCT00003814Phase 3

Eflornithine in Treating Patients With Bladder Cancer

Completed
NCT00086736Phase 2

Neoadjuvant Eflornithine and Bicalutamide Compared With Eflornithine Alone, Bicalutamide Alone, and No Neoadjuvant Therapy in Treating Patients With Localized Prostate Cancer Undergoing Brachytherapy or Radical Prostatectomy

Completed
NCT00003076Phase 2

Eflornithine to Prevent Cancer in Patients With Barrett's Esophagus

Completed

All 19 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
19