Success Metrics

Clinical Success Rate
72.0%

Based on 149 completed trials

Completion Rate
72%(149/207)
Active Trials
272(46%)
Results Posted
95%(142 trials)
Terminated
58(10%)

Phase Distribution

Ph early_phase_1
8
1%
Ph not_applicable
7
1%
Ph phase_2
314
54%
Ph phase_1
171
29%
Ph phase_3
70
12%
Ph phase_4
4
1%

Phase Distribution

179

Early Stage

314

Mid Stage

74

Late Stage

Phase Distribution574 total trials
Early Phase 1First-in-human
8(1.4%)
Phase 1Safety & dosage
171(29.8%)
Phase 2Efficacy & side effects
314(54.7%)
Phase 3Large-scale testing
70(12.2%)
Phase 4Post-market surveillance
4(0.7%)
N/ANon-phased studies
7(1.2%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

60.3%

149 of 247 finished

Non-Completion Rate

39.7%

98 ended early

Currently Active

272

trials recruiting

Total Trials

586

all time

Status Distribution
Active(292)
Completed(149)
Terminated(98)
Other(47)

Detailed Status

Completed149
Active, not recruiting146
Recruiting126
Terminated58
unknown45
Withdrawn40

Development Timeline

Analytics

Development Status

Total Trials
586
Active
272
Success Rate
72.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 18 (1.4%)
Phase 1171 (29.8%)
Phase 2314 (54.7%)
Phase 370 (12.2%)
Phase 44 (0.7%)
N/A7 (1.2%)

Trials by Status

enrolling_by_invitation20%
recruiting12622%
completed14925%
withdrawn407%
active_not_recruiting14625%
suspended20%
not_yet_recruiting183%
terminated5810%
unknown458%

Recent Activity

Clinical Trials (586)

Showing 20 of 586 trialsScroll for more
NCT03606967Phase 2

Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

Recruiting
NCT07005128Phase 3

A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

Recruiting
NCT05632809Phase 2

REStoring lymphoCytes Using NKTR-255* After chemoradiothErapy in Solid Tumors (RESCUE)

Recruiting
NCT06058377Phase 3

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Recruiting
NCT06467357Phase 3

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

Recruiting
NCT06694454Phase 1

Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)

Recruiting
NCT04628767Phase 2

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Recruiting
NCT05198830Phase 2

Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

Recruiting
NCT06287775Phase 1

Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

Recruiting
NCT02726997Phase 1

Matched Paired Pharmacodynamics and Feasibility Study of Durvalumab in Combination With Chemotherapy in Frontline Ovarian Cancer (N-Dur)

Active Not Recruiting
NCT04728230Phase 1

Olaparib and Durvalumab With Carboplatin, Etoposide, and/or Radiation Therapy for the Treatment of Extensive-Stage Small Cell Lung Cancer, PRIO Trial

Active Not Recruiting
NCT06960577Phase 3

Perioperative Durvalumab With Neoadjuvant ddMVAC or Gemcitabine/Cisplatin in Patients With Muscle-invasive Bladder Cancer (NIAGARA-2)

Recruiting
NCT04379596Phase 2

Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)

Recruiting
NCT04106115Phase 1

DURvalumab in Combination With S-488210/S-488211 vAccine in Non-muscle Invasive Bladder CancEr

Recruiting
NCT03907475Phase 2

Durvalumab in Combination With Chemotherapy in Treating Patients With Advanced Solid Tumors, DURVA+ Trial

Recruiting
NCT05211895Phase 3

A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC

Recruiting
NCT07639528Phase 2

Preoperative Durvalumab, Cisplatin, Gemcitabine With or Without Futibatinib Targeted Therapy for the Treatment of Resectable Intrahepatic Cholangiocarcinoma, OPTIC Trial

Not Yet Recruiting
NCT03737643Phase 3

Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients

Active Not Recruiting
NCT06880523Phase 2

STRIDE (Durvalumab + Tremelimumab) With Lenvatinib vs STRIDE Alone in Unresectable Hepatocellular Carcinoma

Recruiting
NCT07637513Phase 3

Tarlatamab and Durvalumab vs. Durvalumab Alone for Limited-Stage-Small Cell Lung Cancer

Not Yet Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
586