Success Metrics

Clinical Success Rate
72.0%

Based on 152 completed trials

Completion Rate
72%(152/211)
Active Trials
275(46%)
Results Posted
95%(145 trials)
Terminated
59(10%)

Phase Distribution

Ph phase_1
171
29%
Ph phase_3
73
12%
Ph not_applicable
7
1%
Ph phase_2
316
53%
Ph early_phase_1
8
1%
Ph phase_4
4
1%

Phase Distribution

179

Early Stage

316

Mid Stage

77

Late Stage

Phase Distribution579 total trials
Early Phase 1First-in-human
8(1.4%)
Phase 1Safety & dosage
171(29.5%)
Phase 2Efficacy & side effects
316(54.6%)
Phase 3Large-scale testing
73(12.6%)
Phase 4Post-market surveillance
4(0.7%)
N/ANon-phased studies
7(1.2%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

60.3%

152 of 252 finished

Non-Completion Rate

39.7%

100 ended early

Currently Active

275

trials recruiting

Total Trials

592

all time

Status Distribution
Active(295)
Completed(152)
Terminated(100)
Other(45)

Detailed Status

Active, not recruiting152
Completed152
Recruiting123
Terminated59
unknown44
Withdrawn41

Development Timeline

Analytics

Development Status

Total Trials
592
Active
275
Success Rate
72.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 18 (1.4%)
Phase 1171 (29.5%)
Phase 2316 (54.6%)
Phase 373 (12.6%)
Phase 44 (0.7%)
N/A7 (1.2%)

Trials by Status

active_not_recruiting15226%
suspended10%
terminated5910%
withdrawn417%
completed15226%
recruiting12321%
not_yet_recruiting183%
enrolling_by_invitation20%
unknown447%

Recent Activity

Clinical Trials (592)

Showing 20 of 592 trialsScroll for more
NCT04892953Phase 2

Local Consolidative Therapy and Durvalumab for Oligoprogressive and Polyprogressive Stage III NSCLC After Chemoradiation and Anti-PD-L1 Therapy

Recruiting
NCT03606967Phase 2

Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

Recruiting
NCT07361497Phase 3

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

Recruiting
NCT06694454Phase 1

Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)

Recruiting
NCT03851614Phase 2

Study of DNA Damage, Angiogenesis, and PD-L1 Inhibitors in Advanced Solid Tumors

Active Not Recruiting
NCT06498635Phase 3

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

Recruiting
NCT06058377Phase 3

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Recruiting
NCT07554339Phase 3

A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)

Recruiting
NCT05713838Phase 2

Organ Preservation With Durvalumab-based Immunotherapy in Combination With Chemoradiation as Definitive Therapy for Early Stage Esophageal Adenocarcinoma With Indication for Radical Surgery

Active Not Recruiting
NCT04269200Phase 3

Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer

Active Not Recruiting
NCT06890598Phase 3

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

Recruiting
NCT05137262Phase 2

A Phase II Multicenter Study of Chemotherapy Versus Chemotherapy Plus Durvalumab (MEDI 4736) in Patients With Lymph Node Positive Urothelial Carcinoma of the Bladder

Active Not Recruiting
NCT07531095Phase 1

Study of Tarlatamab + ZL-1310 +/- Anti-programmed Death Ligand 1 (Anti-PD-L1) in Small Cell Lung Cancer (SCLC)

Recruiting
NCT05198830Phase 2

Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

Recruiting
NCT06287775Phase 1

Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

Recruiting
NCT03706690Phase 3

A Study of Durvalumab as Consolidation Therapy in Non-Small Cell Lung Cancer Patients

Active Not Recruiting
NCT06050252Phase 2

Testing the Combination of the Anticancer Drug Durvalumab With Chemotherapy (Gemcitabine and Cisplatin) at Improving Outcomes for High-Risk Resectable Liver Cancer Before Surgery

Recruiting
NCT03459846Phase 2

A Study of Durvalumab Alone and Durvalumab+Olaparib in Advanced, Platinum-Ineligible Bladder Cancer (BAYOU)

Active Not Recruiting
NCT05215106Phase 2

Short-term Pre-OPerative Durvalumab (MEDI 4736) in Early Small Triple Negative Breast Cancer Patients (POP-Durva)

Active Not Recruiting
NCT02519348Phase 2

A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Advanced Hepatocellular Carcinoma

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
592