Success Metrics

Clinical Success Rate
72.8%

Based on 147 completed trials

Completion Rate
73%(147/202)
Active Trials
269(46%)
Results Posted
91%(134 trials)
Terminated
55(9%)

Phase Distribution

Ph phase_2
313
54%
Ph phase_3
68
12%
Ph early_phase_1
8
1%
Ph not_applicable
7
1%
Ph phase_1
170
29%
Ph phase_4
4
1%

Phase Distribution

178

Early Stage

313

Mid Stage

72

Late Stage

Phase Distribution570 total trials
Early Phase 1First-in-human
8(1.4%)
Phase 1Safety & dosage
170(29.8%)
Phase 2Efficacy & side effects
313(54.9%)
Phase 3Large-scale testing
68(11.9%)
Phase 4Post-market surveillance
4(0.7%)
N/ANon-phased studies
7(1.2%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

60.7%

147 of 242 finished

Non-Completion Rate

39.3%

95 ended early

Currently Active

269

trials recruiting

Total Trials

582

all time

Status Distribution
Active(291)
Completed(147)
Terminated(95)
Other(49)

Detailed Status

Completed147
Active, not recruiting143
Recruiting126
Terminated55
unknown47
Withdrawn40

Development Timeline

Analytics

Development Status

Total Trials
582
Active
269
Success Rate
72.8%
Most Advanced
Phase 4

Trials by Phase

Early Phase 18 (1.4%)
Phase 1170 (29.8%)
Phase 2313 (54.9%)
Phase 368 (11.9%)
Phase 44 (0.7%)
N/A7 (1.2%)

Trials by Status

terminated559%
active_not_recruiting14325%
completed14725%
enrolling_by_invitation20%
recruiting12622%
unknown478%
withdrawn407%
not_yet_recruiting203%
suspended20%

Recent Activity

Clinical Trials (582)

Showing 20 of 582 trialsScroll for more
NCT05450692Phase 3

A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy

Active Not Recruiting
NCT06694454Phase 1

Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)

Not Yet Recruiting
NCT06467357Phase 3

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

Recruiting
NCT04940286Phase 2

Gemcitabine, Nab-paclitaxel, Durvalumab, and Oleclumab Before Surgery for the Treatment of in Resectable/Borderline Resectable Primary Pancreatic Cancer

Active Not Recruiting
NCT05925530Phase 2

Study to Assess Neoadjuvant Durvalumab (D) and Platinum-Based Chemotherapy (CT), Followed by Either Surgery and Adjuvant D or CRT and Consolidation D, in Resectable or Borderline Resectable Stage IIB-IIIB NSCLC (MDT-BRIDGE)

Active Not Recruiting
NCT07005128Phase 3

A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

Recruiting
NCT06058377Phase 3

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Recruiting
NCT03778957Phase 3

A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma

Active Not Recruiting
NCT06117891

An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery

Recruiting
NCT07531095Phase 1

Study of Tarlatamab + ZL-1310 +/- Anti-programmed Death Ligand 1 (Anti-PD-L1) in Small Cell Lung Cancer (SCLC)

Not Yet Recruiting
NCT03682289Phase 2

Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors

Recruiting
NCT07288034Phase 2

Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

Recruiting
NCT04668300Phase 2

Oleclumab and Durvalumab for the Treatment of Recurrent, Refractory, or Metastatic Sarcoma

Active Not Recruiting
NCT02866747Phase 1

A Study Evaluating the Association of Hypofractionated Stereotactic Radiation Therapy and Durvalumab for Patients With Recurrent Glioblastoma

Completed
NCT06880523Phase 2

STRIDE (Durvalumab + Tremelimumab) With Lenvatinib vs STRIDE Alone in Unresectable Hepatocellular Carcinoma

Recruiting
NCT04960709Phase 3

Treatment Combination of Durvalumab, Tremelimumab and Enfortumab Vedotin or Durvalumab and Enfortumab Vedotin in Patients With Muscle Invasive Bladder Cancer Ineligible to Cisplatin or Who Refuse Cisplatin

Active Not Recruiting
NCT03446547Phase 2

Ablative STEreotactic RadiOtherapy wIth Durvalumab (MEDI4736)

Completed
NCT06498635Phase 3

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

Recruiting
NCT06667908Phase 2

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

Recruiting
NCT04628767Phase 2

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
582