Success Metrics

Clinical Success Rate
90.2%

Based on 46 completed trials

Completion Rate
90%(46/51)
Active Trials
6(9%)
Results Posted
35%(16 trials)
Terminated
5(7%)

Phase Distribution

Ph phase_2
19
27%
Ph phase_4
11
16%
Ph phase_1
28
40%
Ph early_phase_1
2
3%
Ph not_applicable
4
6%
Ph phase_3
5
7%

Phase Distribution

30

Early Stage

19

Mid Stage

16

Late Stage

Phase Distribution69 total trials
Early Phase 1First-in-human
2(2.9%)
Phase 1Safety & dosage
28(40.6%)
Phase 2Efficacy & side effects
19(27.5%)
Phase 3Large-scale testing
5(7.2%)
Phase 4Post-market surveillance
11(15.9%)
N/ANon-phased studies
4(5.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

86.8%

46 of 53 finished

Non-Completion Rate

13.2%

7 ended early

Currently Active

6

trials recruiting

Total Trials

70

all time

Status Distribution
Active(7)
Completed(46)
Terminated(7)
Other(10)

Detailed Status

Completed46
unknown10
Terminated5
Recruiting4
Withdrawn2
Active, not recruiting2

Development Timeline

Analytics

Development Status

Total Trials
70
Active
6
Success Rate
90.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (2.9%)
Phase 128 (40.6%)
Phase 219 (27.5%)
Phase 35 (7.2%)
Phase 411 (15.9%)
N/A4 (5.8%)

Trials by Status

withdrawn23%
active_not_recruiting23%
terminated57%
not_yet_recruiting11%
unknown1014%
completed4666%
recruiting46%

Recent Activity

Clinical Trials (70)

Showing 20 of 70 trialsScroll for more
NCT07241065Phase 1

A Study to Investigate the Effect of Capivasertib on the Pharmacokinetics of Oral Dextromethorphan (CYP2D6 Substrate) in Healthy Participants

Recruiting
NCT05068791Early Phase 1

Psilocybin-facilitated Treatment for Chronic Pain

Recruiting
NCT05444556Phase 1

A Study of Imlunestrant (LY3484356) in Female Healthy Participants

Completed
NCT01435798Phase 2

Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial

Completed
NCT02218203Phase 2

Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial

Completed
NCT06383338Phase 1

A Study Investigating the Change in Metabolism Phenotype in Paediatric, Adolescent & Young Adults With Hodgkin or Non-Hodgkin Lymphoma.

Recruiting
NCT04899687Phase 2

Study of Dextromethorphan in OCD and Related Disorders

Recruiting
NCT04923659Early Phase 1

Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity

Active Not Recruiting
NCT05944510Phase 4

Dextromethorphan as an Augmentation Agent in Treatment-resistant Schizophrenia

Completed
NCT06632990Phase 1

A Study Evaluating the Potential of BMS-984923 to Alter the Systemic Exposure of Three Orally Administered Probe Substrates

Active Not Recruiting
NCT03076021Phase 4

Effects of Isotretinoin on CYP2D6 Activity

Completed
NCT03864042Phase 1

Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors

Completed
NCT04887194Phase 1

PK Study to Assess Drug-drug Interaction and QTc Between Sitravatinib and a Cocktail of Substrates

Completed
NCT06348290Phase 1

Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects

Not Yet Recruiting
NCT05181527Phase 4

Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder

Completed
NCT05699993Phase 1

A Study of IBI351 in Healthy Subjects

Completed
NCT05947604Phase 1

DDI Study of Single Oral Dose of Acoziborole With Sequential Co-administration of Midazolam and Dextromethorphan

Completed
NCT05602675Phase 1

A Drug Interaction Study of LY3871801 in Healthy Participants

Completed
NCT05043805Phase 4

Dextromethorphan Added on for Children With Chronic Irritability

Unknown
NCT04226352Phase 1

Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder

Completed

Drug Details

Intervention Type
DRUG
Total Trials
70