Success Metrics

Clinical Success Rate
81.8%

Based on 9 completed trials

Completion Rate
82%(9/11)
Active Trials
0(0%)
Results Posted
89%(8 trials)
Terminated
2(17%)

Phase Distribution

Ph phase_1
6
50%
Ph phase_2
6
50%

Phase Distribution

6

Early Stage

6

Mid Stage

0

Late Stage

Phase Distribution12 total trials
Phase 1Safety & dosage
6(50.0%)
Phase 2Efficacy & side effects
6(50.0%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

75.0%

9 of 12 finished

Non-Completion Rate

25.0%

3 ended early

Currently Active

0

trials recruiting

Total Trials

12

all time

Status Distribution
Completed(9)
Terminated(3)

Detailed Status

Completed9
Terminated2
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
12
Active
0
Success Rate
81.8%
Most Advanced
Phase 2

Trials by Phase

Phase 16 (50.0%)
Phase 26 (50.0%)

Trials by Status

completed975%
terminated217%
withdrawn18%

Recent Activity

Clinical Trials (12)

Showing 12 of 12 trials
NCT01609231Phase 2

A Trial of Dalotuzumab in Combination With Irinotecan Versus Cetuximab and Irinotecan for Participants With Metastatic Rectal Cancers (mRC) (MK-0646-025)

Terminated
NCT01605396Phase 2

A Phase II Trial of Ridaforolimus and Exemestane, Compared to Ridaforolimus, Dalotuzumab and Exemestane in Participants With Breast Cancer (MK-8669-064)

Completed
NCT00635778Phase 1

A Dose-finding Study of Dalotuzumab in Subjects With Advanced Solid Tumors (MK-0646-002)

Completed
NCT01243762Phase 1

A Study of Dalotuzumab + MK-2206, Dalotuzumab + MK-0752, and Dalotuzumab + Ridaforolimus Combination Therapies in Participants With Advanced Cancer (MK-0646-027)

Terminated
NCT00701103Phase 1

Dose Escalation Trial of Dalotuzumab (MK-0646) in Advanced Solid Tumors and Multiple Myeloma (MK-0646-001)

Completed
NCT00694356Phase 1

Study of Dalotuzumab (MK-0646) in Adults With Solid Tumors (MK-0646-009)

Completed
NCT00654420Phase 2

A Study Evaluating Dalotuzumab (MK-0646) in Combination With Erlotinib for Participants With Non-Small Cell Lung Cancer (MK-0646-007)

Completed
NCT00614393Phase 2

Study of Dalotuzumab (MK-0646) in Combination With Cetuximab and Irinotecan in Metastatic Colorectal Cancer (MK-0646-004)

Completed
NCT01234857Phase 2

A Study of Ridaforolimus (MK-8669) in Combination With Dalotuzumab (MK-0646) Compared to Standard of Care Treatment in Estrogen Receptor Positive Breast Cancer Patients (MK-8669-041 AM3)

Completed
NCT00951444Phase 2

Gemcitabine Hydrochloride and Carboplatin With or Without MK-0646 as First-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

Withdrawn
NCT01431547Phase 1

Study of Dalotuzumab Alone and With Ridaforolimus in Pediatric Participants With Advanced Solid Tumors (MK-8669-062 AM1)

Completed
NCT01220570Phase 1

The Growth Factor Signature (GFS) as an Intermediate Biomarker of Response for Development of PI3K-Pathway Inhibitors in Patients With Breast Cancer (MK-8669-050)

Completed

All 12 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
12