Success Metrics

Clinical Success Rate
88.2%

Based on 15 completed trials

Completion Rate
88%(15/17)
Active Trials
4(15%)
Results Posted
60%(9 trials)
Terminated
2(7%)

Phase Distribution

Ph early_phase_1
1
4%
Ph phase_4
1
4%
Ph phase_2
12
44%
Ph phase_1
9
33%

Phase Distribution

10

Early Stage

12

Mid Stage

1

Late Stage

Phase Distribution23 total trials
Early Phase 1First-in-human
1(4.3%)
Phase 1Safety & dosage
9(39.1%)
Phase 2Efficacy & side effects
12(52.2%)
Phase 4Post-market surveillance
1(4.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

88.2%

15 of 17 finished

Non-Completion Rate

11.8%

2 ended early

Currently Active

4

trials recruiting

Total Trials

27

all time

Status Distribution
Active(4)
Completed(15)
Terminated(2)
Other(6)

Detailed Status

Completed15
unknown6
Recruiting2
Active, not recruiting2
Terminated2

Development Timeline

Analytics

Development Status

Total Trials
27
Active
4
Success Rate
88.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (4.3%)
Phase 19 (39.1%)
Phase 212 (52.2%)
Phase 41 (4.3%)

Trials by Status

recruiting27%
completed1556%
active_not_recruiting27%
terminated27%
unknown622%

Recent Activity

Clinical Trials (27)

Showing 20 of 27 trialsScroll for more
NCT03810807Phase 1

Study of Dacomitinib and Osimertinib for Patients With Advanced EGFR Mutant Lung Cancer

Completed
NCT04504071Phase 2

Dacomitinib in Lung Cancer With Uncommon EGFR Mutations

Active Not Recruiting
NCT02039336Phase 1

Dacomitinib Plus PD-0325901 in Advanced KRAS Mutant NSCLC

Completed
NCT04027647Phase 2

Phase 2 Study of Dacomitinib in NSCLC

Active Not Recruiting
NCT04609319

Real World Utilization and Outcomes With Dacomitinib First Line Treatment for EGFR Mutation-positive Advanced Non Small Cell Lung Cancer Among Asian Patients - A Multi Center Chart Review

Completed
NCT03755102Early Phase 1

A Pilot Study of Dacomitinib With or Without Osimertinib for Patients With Metastatic EGFR Mutant Lung Cancers With Disease Progression on Osimertinib.

Completed
NCT05834348

A Study to Learn About the Effectiveness of Cancer Medicines in Patients With Metastatic Non-small Cell Lung Cancer in Norway.

Completed
NCT04511533Phase 4

Dacomitinib for Treatment of Patients in India With Metastatic Non Small Cell Lung Cancer With EGFR Activating Mutations

Completed
NCT03878524Phase 1

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Terminated
NCT02925234Phase 2

The Drug Rediscovery Protocol (DRUP Trial)

Recruiting
NCT05271916Phase 1

First-line Treatment With Dacomitinib Plus Anlotinib for Patients With Advanced NSCLC With EGFR 21L858R Mutations

Recruiting
NCT04811001Phase 2

Best EGFR-TKI Sequence in NSCLC Harboring EGFR Mutations

Unknown
NCT01920061Phase 1

A Study Of PF-05212384 In Combination With Other Anti-Tumor Agents and in Combination With Cisplatin in Patients With Triple Negative Breast Cancer in an Expansion Arm (TNBC)

Completed
NCT01728233Phase 2

Dacomitinib (PF-00299804) in Advanced/Metastatic Squamous Cell Carcinoma of the Penis

Completed
NCT04768491

Dacomitinib Treatment Followed by 3rd Generation EGFR-TKI in Patients With EGFR Mutation Positive Advanced NSCLC

Unknown
NCT04675008Phase 2

Central Nervous System(CNS) Efficacy of Dacomitinib

Unknown
NCT03865446Phase 1

Evaluate Severe Hepatic Impairment on Dacomitinib PK

Completed
NCT04575415

Bevacizumab Plus EGFR-TKIs in Chinese Patients With EGFR-mutant NSCLC: a Real-world Study

Unknown
NCT02382796Phase 2

A Rollover Protocol of Dacomitinib For Patients In Japan

Completed
NCT04339829Phase 2

An Open Label, Multicenter, Phase II Study of Dacomitinib for EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) With Brain Metastases

Unknown

Drug Details

Intervention Type
DRUG
Total Trials
27