Success Metrics

Clinical Success Rate
81.0%

Based on 17 completed trials

Completion Rate
81%(17/21)
Active Trials
8(23%)
Results Posted
65%(11 trials)
Terminated
4(11%)

Phase Distribution

Ph phase_1
13
37%
Ph phase_2
16
46%
Ph phase_4
1
3%
Ph phase_3
2
6%

Phase Distribution

13

Early Stage

16

Mid Stage

3

Late Stage

Phase Distribution32 total trials
Phase 1Safety & dosage
13(40.6%)
Phase 2Efficacy & side effects
16(50.0%)
Phase 3Large-scale testing
2(6.3%)
Phase 4Post-market surveillance
1(3.1%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

68.0%

17 of 25 finished

Non-Completion Rate

32.0%

8 ended early

Currently Active

8

trials recruiting

Total Trials

35

all time

Status Distribution
Active(9)
Completed(17)
Terminated(8)
Other(1)

Detailed Status

Completed17
Active, not recruiting5
Terminated4
Withdrawn4
Recruiting3
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
35
Active
8
Success Rate
81.0%
Most Advanced
Phase 4

Trials by Phase

Phase 113 (40.6%)
Phase 216 (50.0%)
Phase 32 (6.3%)
Phase 41 (3.1%)

Trials by Status

recruiting39%
not_yet_recruiting13%
terminated411%
withdrawn411%
completed1749%
unknown13%
active_not_recruiting514%

Recent Activity

Clinical Trials (35)

Showing 20 of 35 trialsScroll for more
NCT03572764Phase 1

CPX-351 (Vyxeos™) for Transplant Eligible, Higher Risk Patients With Myelodysplastic Syndrome

Active Not Recruiting
NCT04990102Phase 1

Phase IB/II of CPX-351 for Relapse Prevention in AML

Recruiting
NCT04231851Phase 2

CPX-351 and Glasdegib for Newly Diagnosed Acute Myelogenous Leukemia With MDS Related Changes or Therapy-related Acute Myeloid Leukemia

Active Not Recruiting
NCT05656248Phase 2

Study of CPX-351 (VYXEOS) in Individuals < 22 Years With Secondary Myeloid Neoplasms

Active Not Recruiting
NCT03897127Phase 3

Study of Standard Intensive Chemotherapy Versus Intensive Chemotherapy With CPX-351 in Adult Patients With Newly Diagnosed AML and Intermediate- or Adverse Genetics

Active Not Recruiting
NCT04668885Phase 2

CPX-351 as a Novel Approach for the Treatment of Older Patients With AML and MDS

Active Not Recruiting
NCT07008638Phase 1

Phase I/II Clinical Trial of Proteasome Inhibitor in Combination With CPX-351 for the Treatment of Newly-Diagnosed TP53-mutated Acute Myeloid Leukemia (AML)

Recruiting
NCT03844997Phase 1

Phase I/II Trial of CPX-351 + Palbociclib in Patients With Acute Myeloid Leukemia

Completed
NCT03575325Phase 2

Vyxeos(CPX-351) in Adults w R/R Acute Lymphoblastic Leukemia

Completed
NCT04992949Phase 2

Evaluation of CPX-351 Monotherapy in Acute Myeloid Leukemia Secondary to Myeloproliferative Neoplasm

Completed
NCT04982354Phase 1

Induction Therapy for Patients With FLT3 Mutated Acute Myeloid Leukemia

Withdrawn
NCT03957876Phase 2

CPX-351 Therapy for MDS After Hypomethylating Agent Failure

Terminated
NCT05628623Phase 2

Testing the Use of Combination Therapy in Patients With Persistent Low Level Acute Myeloid Leukemia (AML) Following Initial Treatment

Not Yet Recruiting
NCT03335267Phase 2

Investigator Initiated Trial of CPX-351 for Untreated Acute Myeloid Leukemia

Completed
NCT05829434Phase 2

Magrolimab Plus Intensive Chemotherapy in Newly Diagnosed AML or HR-MDS

Withdrawn
NCT04209725Phase 2

A Study of CPX-351 (Vyxeos™) With Quizartinib for the Treatment of FLT3-ITD Mutation-Positive Acute Myeloid Leukemia

Terminated
NCT04075747Phase 1

A Phase 1b Master Trial to Investigate CPX-351 in Subjects With Previously Untreated Acute Myeloid Leukemia

Completed
NCT04061239Phase 2

Comparison of Therapies Before Stem Cell Transplantation in Patients With Higher Risk MDS and Oligoblastic AML

Recruiting
NCT03878927Phase 1

CPX-351+GO in Subjects 55 Years Old, or Older, With AML

Terminated
NCT03393611Phase 1

CPX-351 Salvage Therapy Followed by Haplo-Cord Transplant for Relapsed/Refractory Leukemia or Myelodysplastic Syndrome

Completed

Drug Details

Intervention Type
DRUG
Total Trials
35