Success Metrics

Clinical Success Rate
66.7%

Based on 4 completed trials

Completion Rate
67%(4/6)
Active Trials
5(36%)
Results Posted
100%(4 trials)
Terminated
2(14%)

Phase Distribution

Ph phase_2
5
36%
Ph phase_3
6
43%
Ph phase_1
2
14%

Phase Distribution

2

Early Stage

5

Mid Stage

6

Late Stage

Phase Distribution13 total trials
Phase 1Safety & dosage
2(15.4%)
Phase 2Efficacy & side effects
5(38.5%)
Phase 3Large-scale testing
6(46.2%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

50.0%

4 of 8 finished

Non-Completion Rate

50.0%

4 ended early

Currently Active

5

trials recruiting

Total Trials

14

all time

Status Distribution
Active(5)
Completed(4)
Terminated(4)
Other(1)

Detailed Status

Completed4
Recruiting3
Withdrawn2
Active, not recruiting2
Terminated2
unknown1

Development Timeline

Analytics

Development Status

Total Trials
14
Active
5
Success Rate
66.7%
Most Advanced
Phase 3

Trials by Phase

Phase 12 (15.4%)
Phase 25 (38.5%)
Phase 36 (46.2%)

Trials by Status

completed429%
withdrawn214%
unknown17%
recruiting321%
active_not_recruiting214%
terminated214%

Recent Activity

Clinical Trials (14)

Showing 14 of 14 trials
NCT06541704Phase 3

A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

Recruiting
NCT05133531Phase 3

A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment

Active Not Recruiting
NCT07154745Phase 3

A Study to Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working Efficiently

Recruiting
NCT05744921Phase 3

A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works

Recruiting
NCT05070858Phase 3

A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis

Active Not Recruiting
NCT06028594

Compassionate Use of Pozelimab and Cemdisiran Combination Therapy in Patients With Paroxysmal Nocturnal Hemoglobinuria

Unknown
NCT04888507Phase 2

Pozelimab and Cemdisiran Combination Therapy in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Switch From Eculizumab Therapy

Completed
NCT05131204Phase 3

Efficacy and Safety of the Combination of Pozelimab and Cemdisiran Versus Continued Eculizumab or Ravulizumab Treatment in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria

Terminated
NCT04811716Phase 2

Pozelimab and Cemdisiran Combination Treatment in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Received Pozelimab Monotherapy

Completed
NCT03841448Phase 2

A Study of Cemdisiran in Adults With Immunoglobulin A Nephropathy (IgAN)

Terminated
NCT04940364Phase 1

A Study to Examine the Safety, Tolerability and Biological Effects of Single Doses of Subcutaneously and Intravenously Administered Pozelimab as Monotherapy and in Combination With Single Doses of Subcutaneously Administered Cemdisiran in Adult Japanese Healthy Volunteers

Completed
NCT04601844Phase 1

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pozelimab in Combination With Cemdisiran in Healthy Adult Volunteers

Completed
NCT03999840Phase 2

Eculizumab to Cemdisiran Switch in aHUS

Withdrawn
NCT03303313Phase 2

A Study of an Investigational Drug, Cemdisiran (ALN-CC5), in Patients With Atypical Hemolytic Uremic Syndrome

Withdrawn

All 14 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
14