Success Metrics

Clinical Success Rate
71.4%

Based on 10 completed trials

Completion Rate
71%(10/14)
Active Trials
3(17%)
Results Posted
90%(9 trials)
Terminated
4(22%)

Phase Distribution

Ph phase_1
6
33%
Ph phase_2
11
61%

Phase Distribution

6

Early Stage

11

Mid Stage

0

Late Stage

Phase Distribution17 total trials
Phase 1Safety & dosage
6(35.3%)
Phase 2Efficacy & side effects
11(64.7%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

71.4%

10 of 14 finished

Non-Completion Rate

28.6%

4 ended early

Currently Active

3

trials recruiting

Total Trials

18

all time

Status Distribution
Active(3)
Completed(10)
Terminated(4)
Other(1)

Detailed Status

Completed10
Terminated4
Active, not recruiting2
unknown1
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
18
Active
3
Success Rate
71.4%
Most Advanced
Phase 2

Trials by Phase

Phase 16 (35.3%)
Phase 211 (64.7%)

Trials by Status

active_not_recruiting211%
unknown16%
terminated422%
recruiting16%
completed1056%

Recent Activity

Clinical Trials (18)

Showing 18 of 18 trials
NCT04806906Phase 2

Pilot Study of CC 486 (Oral Azacitidine) Plus BSC as Maintenance After sc Azacitidine in Elderly HR-IPSS-R MDS Patients

Completed
NCT05413018Phase 2

An Efficacy and Safety Study of Oral Azacitidine (CC-486) as Maintenance Therapy in Chinese Participants With Acute Myeloid Leukemia in Complete Remission

Active Not Recruiting
NCT02494258Phase 2

A Study to Evaluate Long-term Safety of CC-486 (Oral Azacitidine) in Subjects With Hematological Disorders

Completed
NCT05287568Phase 1

CC-486 and Venetoclax for Acute Myeloid Leukemia

Recruiting
NCT04174196Phase 2

A Study of Lenalidomide and CC-486 With Radiation Therapy in Patients With Plasmacytoma

Active Not Recruiting
NCT02546986Phase 2

Safety and Efficacy Study of CC-486 With MK-3475 to Treat Locally Advanced or Metastatic Non-small Cell Lung Cancer

Completed
NCT04778410Phase 2

Study of Magrolimab Combinations in Participants With Myeloid Malignancies

Terminated
NCT02250326Phase 2

Safety and Efficacy Study of Nab®-Paclitaxel With CC-486 or Nab®-Paclitaxel With Durvalumab, and Nab®-Paclitaxel Monotherapy as Second/Third-line Treatment for Advanced Non-small Cell Lung Cancer

Completed
NCT03493646Phase 2

Evaluating in Vivo AZA Incorporation in Mononuclear Cells Following Vidaza or CC486

Completed
NCT04722601Phase 1

A Dose-Finding and Efficacy Study of Venetoclax, CC-486, and Obinutuzumab in Follicular Lymphoma

Terminated
NCT04887857Phase 1

A Study to Assess Safety and Tolerability of CC-486 (ONUREG®, Oral Azacitidine) in Combination Therapy in Participants With Acute Myeloid Leukemia (AML)

Completed
NCT02900560Phase 2

Study of Pembrolizumab With or Without CC-486 in Patients With Platinum-resistant Ovarian Cancer

Terminated
NCT03723135

Expanded Access for CC-486

Unknown
NCT02223052Phase 1

Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies

Completed
NCT01478685Phase 1

A Phase 1 Study of CC-486 as a Single Agent and in Combination With Carboplatin or ABI-007 in Subjects With Relapsed or Refractory Solid Tumors

Completed
NCT02374099Phase 2

Study to Assess the Efficacy and Safety of the Epigenetic Modifying Effects of CC-486 (Oral Azacitidine) in Combination With Fulvestrant

Terminated
NCT02269943Phase 2

Safety and Efficacy of CC-486 in Previously Treated Patients With Locally Advanced or Metastatic Nasopharyngeal Carcinoma

Completed
NCT01835587Phase 1

Safety Study of Oral Azacitidine (CC-486) as Maintenance Therapy After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Participants With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS).

Completed

All 18 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
18