Success Metrics

Clinical Success Rate
78.9%

Based on 15 completed trials

Completion Rate
79%(15/19)
Active Trials
2(9%)
Results Posted
53%(8 trials)
Terminated
4(17%)

Phase Distribution

Ph phase_3
8
35%
Ph not_applicable
1
4%
Ph phase_4
4
17%

Phase Distribution

0

Early Stage

0

Mid Stage

12

Late Stage

Phase Distribution13 total trials
Phase 3Large-scale testing
8(61.5%)
Phase 4Post-market surveillance
4(30.8%)
N/ANon-phased studies
1(7.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

71.4%

15 of 21 finished

Non-Completion Rate

28.6%

6 ended early

Currently Active

2

trials recruiting

Total Trials

23

all time

Status Distribution
Active(2)
Completed(15)
Terminated(6)

Detailed Status

Completed15
Terminated4
Withdrawn2
Recruiting1
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
23
Active
2
Success Rate
78.9%
Most Advanced
Phase 4

Trials by Phase

Phase 38 (61.5%)
Phase 44 (30.8%)
N/A1 (7.7%)

Trials by Status

terminated417%
withdrawn29%
recruiting14%
active_not_recruiting14%
completed1565%

Recent Activity

Clinical Trials (23)

Showing 20 of 23 trialsScroll for more
NCT05959304Phase 4

Post Marketing Study to Evaluate the Safety and Effectiveness of Brolucizumab in Patients With Diabetic Macular Edema.

Completed
NCT04932980Not Applicable

Comparison of Rapid Aflibercept and Brolucizumab T&E in wAMD

Active Not Recruiting
NCT04543331

Observational Study to Evaluate Fluid Resolution and Effectiveness in Patients Receiving Beovu in Neovascular Age-related Macular Degeneration and Visual Impairment Due to Diabetic Macular Edema

Completed
NCT04679935Phase 4

Efficacy and Safety of Two Different Brolucizumab 6 mg Dosing Regimens in Neovascular Age-related Macular Degeneration

Completed
NCT04774926Phase 4

Study of Innovative Multimodal Imaging Biomarkers to Predict Anatomical Outcome in Naive Patients With wAMD Treated With Brolucizumab.

Completed
NCT04764656

Observational Study to Evaluate Fluid Resolution and Effectiveness of Brolucizumab for nAMD in Portugal

Terminated
NCT04985487

Regulatory Post-Marketing Surveillance Study for Brolucizumab

Recruiting
NCT05266495

Effectiveness of Brolucizumab in Pre-treated Patients With nAMD in the Real-world Setting

Terminated
NCT03481660Phase 3

A Study of the Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema

Completed
NCT05112835

Brolucizumab Treatment Experience Study of Patients With nAMD in UK Routine Clinical Practice

Terminated
NCT04597632Phase 3

An Extension Study Assessing the Efficacy and Safety of Brolucizumab in a Treat-to-Control Regimen in Patients With Neovascular Age-related Macular Degeneration Who Have Completed the CRTH258A2303 (TALON) Study

Completed
NCT04058067Phase 3

To Compare Brolucizumab to Aflibercept in Chinese Patients With Visual Impairment Due to Diabetic Macular Edema

Completed
NCT04662944

A Non-interventional Study to Assess the Influence of Automated Optical Coherence Tomography Image Enrichment With Segmentation Information on Disease Activity Assessment in Patients Treated With Licensed Anti- VEGF Injections

Completed
NCT05710471Phase 4

Treatment of Recalcitrant Neovascular AMD Using Brolocizumab With Immediate T&E

Completed
NCT03710564Phase 3

Study of Safety and Efficacy of Brolucizumab 6 mg Dosed Every 4 Weeks Compared to Aflibercept 2 mg Dosed Every 4 Weeks in Patients With Retinal Fluid Despite Frequent Anti-VEGF Injections

Terminated
NCT03481634Phase 3

Study of Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema

Completed
NCT05657158

Analysis of Imaging Features From Patients Treated With Brolucizumab in the Post-marketing Setting With Reports of Retinal Vasculitis and/or Retinal Vascular Occlusion

Completed
NCT03917472Phase 3

Efficacy and Safety of Brolucizumab vs Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema

Completed
NCT05111743

Real-world Evaluation of Brolucizumab for the Treatment of Neovascular (Wet) Age-related Macular Degeneration (AMD) (Komodo Health)

Completed
NCT05082415

Real-world Evaluation of Brolucizumab for the Treatment of Neovascular (Wet) Age-related Macular Degeneration (AMD) (IRIS Study)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
23