Success Metrics

Clinical Success Rate
69.2%

Based on 27 completed trials

Completion Rate
69%(27/39)
Active Trials
60(45%)
Results Posted
115%(31 trials)
Terminated
12(9%)

Phase Distribution

Ph early_phase_1
1
1%
Ph phase_2
67
51%
Ph phase_3
15
11%
Ph phase_1
33
25%
Ph not_applicable
9
7%
Ph phase_4
3
2%

Phase Distribution

34

Early Stage

67

Mid Stage

18

Late Stage

Phase Distribution128 total trials
Early Phase 1First-in-human
1(0.8%)
Phase 1Safety & dosage
33(25.8%)
Phase 2Efficacy & side effects
67(52.3%)
Phase 3Large-scale testing
15(11.7%)
Phase 4Post-market surveillance
3(2.3%)
N/ANon-phased studies
9(7.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

64.3%

27 of 42 finished

Non-Completion Rate

35.7%

15 ended early

Currently Active

60

trials recruiting

Total Trials

132

all time

Status Distribution
Active(81)
Completed(27)
Terminated(15)
Other(9)

Detailed Status

Recruiting38
Completed27
Active, not recruiting22
Not yet recruiting21
Terminated12
unknown9

Development Timeline

Analytics

Development Status

Total Trials
132
Active
60
Success Rate
69.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.8%)
Phase 133 (25.8%)
Phase 267 (52.3%)
Phase 315 (11.7%)
Phase 43 (2.3%)
N/A9 (7.0%)

Trials by Status

recruiting3829%
withdrawn32%
completed2720%
unknown97%
terminated129%
active_not_recruiting2217%
not_yet_recruiting2116%

Recent Activity

Clinical Trials (132)

Showing 20 of 132 trialsScroll for more
NCT07495631Not Applicable

Pediatric-Inspired Regimen Combined With Venetoclax and Immunotherapy for Adult Ph-Negative Acute Lymphoblastic Leukemia

Recruiting
NCT03147612Phase 2

Low-Intensity Chemotherapy, Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia

Active Not Recruiting
NCT06287229Phase 1

Phase Ib/II Study Assessing the Clinical Activity and Safety of Brexucabtagene Autoleucel as a Consolidation in Patients With Relapsed/Refractory (R/R) and Newly Diagnosed B-cell Acute Lymphocytic Leukemia (ALL) Post Cytoreduction With Mini-HCVD-inotuzumab-blinatumomab/HCVAD-inotuzumab-blinatumomab

Recruiting
NCT06570798Phase 2

A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

Recruiting
NCT07570173Phase 2

A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005)

Recruiting
NCT06317662Phase 2

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

Recruiting
NCT06124157Phase 2

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

Recruiting
NCT02143414Phase 2

Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia

Active Not Recruiting
NCT02003222Phase 3

Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

Active Not Recruiting
NCT03739814Phase 2

Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia

Recruiting
NCT04530565Phase 3

Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

Active Not Recruiting
NCT05645718Phase 2

Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic Leukemia

Recruiting
NCT03914625Phase 3

A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

Active Not Recruiting
NCT02101853Phase 3

Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia

Active Not Recruiting
NCT07493161Not Applicable

Chemotherapy With Targeted-Immunotherapy for Newly Diagnosed Ph+ ALL

Recruiting
NCT03849651Phase 2

TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

Active Not Recruiting
NCT07387926Phase 1

Safety and Efficacy of Asciminib in Pediatrics and Young Adults With Relapse/Refractory (r/r) Philadelphia Positive (Ph+) or ABL-class Ph-like Acute Lymphoblastic Leukemia (ALL)

Recruiting
NCT03959085Phase 3

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

Recruiting
NCT06533748Phase 2

Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and Lymphoma

Recruiting
NCT01371630Phase 1

Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia

Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
132