Success Metrics

Clinical Success Rate
83.7%

Based on 36 completed trials

Completion Rate
84%(36/43)
Active Trials
0(0%)
Results Posted
53%(19 trials)
Terminated
7(14%)

Phase Distribution

Ph phase_3
2
4%
Ph phase_1
24
48%
Ph early_phase_1
1
2%
Ph phase_2
23
46%

Phase Distribution

25

Early Stage

23

Mid Stage

2

Late Stage

Phase Distribution50 total trials
Early Phase 1First-in-human
1(2.0%)
Phase 1Safety & dosage
24(48.0%)
Phase 2Efficacy & side effects
23(46.0%)
Phase 3Large-scale testing
2(4.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

75.0%

36 of 48 finished

Non-Completion Rate

25.0%

12 ended early

Currently Active

0

trials recruiting

Total Trials

50

all time

Status Distribution
Completed(36)
Terminated(12)
Other(2)

Detailed Status

Completed36
Terminated7
Withdrawn5
unknown2

Development Timeline

Analytics

Development Status

Total Trials
50
Active
0
Success Rate
83.7%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (2.0%)
Phase 124 (48.0%)
Phase 223 (46.0%)
Phase 32 (4.0%)

Trials by Status

completed3672%
terminated714%
unknown24%
withdrawn510%

Recent Activity

Clinical Trials (50)

Showing 20 of 50 trialsScroll for more
NCT02113878Phase 1

Phase Ib Study of BKM120 With Cisplatin and XRT in High Risk Locally Advanced Squamous Cell Cancer of Head and Neck

Completed
NCT02159066Phase 2

LGX818 and MEK162 in Combination With a Third Agent (BKM120, LEE011, BGJ398 or INC280) in Advanced BRAF Melanoma

Completed
NCT01397877Phase 2

GINECO-EN102b - BKM120 as Monotherapy in the Treatment of Initial or Recurrent Metastatic Endometrial Cancer

Completed
NCT01591421Phase 1

P13Kinase Inhibitor BKM120 in Combination With Panitumumab in Metastatic/Advanced RAS-Wild Type Colorectal Cancer.

Completed
NCT02117817Phase 1

Phase I BKM120/Abraxane in Solid Tumors, Expansion Phase Recurrent Endometrial or Ovarian Cancer

Withdrawn
NCT02220855Phase 2

A Study of BKM120 (Buparlisib) in Relapsed or Refractory Thymomas

Completed
NCT02000882Phase 2

STAR Cape+BKM120 MBC With Brain Met

Completed
NCT01806649Phase 2

BKM120 in Esophageal Squamous Cell Carcinoma After Failure of First Line Chemotherapy

Terminated
NCT01695473Phase 2

Neoadjuvant BKM120 in High-risk Prostate Cancer

Terminated
NCT01468688Phase 1

A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients

Completed
NCT01730248Phase 1

A Study to Find the Maximum Tolerated Dose of the Experimental Combination of the Drugs INC424 and BKM120 in Patients With Primary or Secondary Myelofibrosis

Terminated
NCT01576666Phase 1

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Completed
NCT02088684Phase 1

Study of LEE011 With Fulvestrant and BYL719 or BKM120 in Advanced Breast Cancer

Completed
NCT01634061Phase 1

Phase Ib of Abiraterone Acetate Plus BEZ235 or BKM120 in Castration-resistant Prostate Cancer (CRPC) Patients

Completed
NCT01155453Phase 1

A Study to Investigate Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of BKM120 Plus GSK1120212 in Selected Advanced Solid Tumor Patients

Completed
NCT01727128Phase 1

Pharmacokinetic Study of BKM120 in Subjects With Hepatic Impairment

Completed
NCT01626209Phase 1

A Phase I Study of BKM120 in Adult Chinese Patients With Advanced Solid Tumors

Completed
NCT01283503Phase 1

A Study of BKM120 in Adult Japanese Patients With Advanced Solid Tumors

Completed
NCT01068483Phase 1

Safety of BKM120 Monotherapy in Advanced Solid Tumor Patients

Completed
NCT01629615Phase 2

A Trial of BKM120 (a PI3K Inhibitor) in Patients With Triple Negative Metastatic Breast Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
50