Success Metrics

Clinical Success Rate
94.4%

Based on 34 completed trials

Completion Rate
94%(34/36)
Active Trials
0(0%)
Results Posted
74%(25 trials)
Terminated
2(5%)

Phase Distribution

Ph phase_1
16
43%
Ph phase_2
14
38%
Ph phase_3
5
14%
Ph not_applicable
1
3%

Phase Distribution

16

Early Stage

14

Mid Stage

5

Late Stage

Phase Distribution36 total trials
Phase 1Safety & dosage
16(44.4%)
Phase 2Efficacy & side effects
14(38.9%)
Phase 3Large-scale testing
5(13.9%)
N/ANon-phased studies
1(2.8%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

94.4%

34 of 36 finished

Non-Completion Rate

5.6%

2 ended early

Currently Active

0

trials recruiting

Total Trials

37

all time

Status Distribution
Completed(34)
Terminated(2)
Other(1)

Detailed Status

Completed34
Terminated2
unknown1

Development Timeline

Analytics

Development Status

Total Trials
37
Active
0
Success Rate
94.4%
Most Advanced
Phase 3

Trials by Phase

Phase 116 (44.4%)
Phase 214 (38.9%)
Phase 35 (13.9%)
N/A1 (2.8%)

Trials by Status

completed3492%
unknown13%
terminated25%

Recent Activity

Clinical Trials (37)

Showing 20 of 37 trialsScroll for more
NCT00716417Phase 1

Study to Determine the Maximum Tolerated Dose of BIBW 2992 (Afatinib) When Combined With Cisplatin/Paclitaxel or Cisplatin/5-FU in Patients With Advanced Solid Tumours

Completed
NCT00950742Phase 1

Phase I Open Label Trial to Assess Safety of BIBW 2992 (Afatinib) in Combination With Herceptin® in Patients With HER2-positive Advanced Breast Cancer.

Completed
NCT02171650Phase 1

BIBW 2992 in Patients With Advanced Solid Tumors

Completed
NCT01542437Phase 2

Treatment With BIBW 2992, Irreversible Inhibitor of EGFR and HER-2 in Non-small Cell Lung Cancer

Completed
NCT01156545Phase 2

BIBW 2992 Plus Simvastatin vs. BIBW 2992 in Previously Treated Patients With Advanced Non-adenocarcinomatous NSCLC

Completed
NCT01679405Phase 1

BIBW 2992 as add-on to Gem/Cis in Advanced Biliary Tract Cancer

Terminated
NCT01125566Phase 3

LUX-Breast 1: BIBW 2992 (Afatinib) in HER2-positive Metastatic Breast Cancer Patients After One Prior Herceptin Treatment

Completed
NCT02271906Phase 2

The ATTAIN Study: A Therapeutic Trial of Afatinib In the Neoadjuvant Setting

Terminated
NCT01121393Phase 3

BIBW 2992 (Afatinib) vs Gemcitabine-cisplatin in 1st Line Non-small Cell Lung Cancer (NSCLC)

Completed
NCT00949650Phase 3

BIBW 2992 (Afatinib) Versus Chemotherapy as First Line Treatment in NSCLC With EGFR Mutation

Completed
NCT01074177Not Applicable

Understanding Mechanisms of Acquired Resistance to BIBW2992

Completed
NCT00727506Phase 2

BIBW 2992 (Afatinib) With or Without Daily Temozolomide in the Treatment of Patients With Recurrent Malignant Glioma

Completed
NCT01085136Phase 3

LUX-Lung 5: Afatinib Plus Weekly Paclitaxel Versus Investigator's Choice of Single Agent Chemotherapy Following Afatinib Monotherapy in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib

Completed
NCT01209650

LUX Lung Special Access Scheme Australia Named Patient Use (NPU)

Unknown
NCT00525148Phase 2

LUX Lung 2 Phase II Single Arm BIBW 2992 "Afatinib" in NSCLC With EGFR Activating Mutations

Completed
NCT00656136Phase 3

BIBW 2992 and BSC Versus Placebo and BSC in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib (LUX-LUNG 1)

Completed
NCT00514943Phase 2

BIBW 2992 (Afatinib) in Head & Neck Cancer

Completed
NCT00809133Phase 1

Trial Exploring Afatinib (BIBW 2992) + Paclitaxel (Part A), Afatinib + Paclitaxel + Bevacizumab (Part B), Afatinib + Carboplatin (Part C) and Afatinib+ Paclitaxel +Carboplatin(Part D) in Patients With Advanced Solid Tumours

Completed
NCT00993499Phase 1

Trial of Continuous Once Daily Oral Treatment Using BIBW 2992 (Afatinib) Plus Sirolimus (Rapamune®) in Patients With Non-small Cell Lung Cancer Harbouring an EGFR Mutation and/or Disease Progression Following Prior Erlotinib or Gefitinib

Completed
NCT01090011Phase 1

Trial of BIBW 2992 (Afatinib) + Cetuximab in Non-Small Cell Lung Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
37