Success Metrics

Clinical Success Rate
50.0%

Based on 6 completed trials

Completion Rate
50%(6/12)
Active Trials
1(6%)
Results Posted
50%(3 trials)
Terminated
6(38%)

Phase Distribution

Ph phase_1
10
63%
Ph phase_2
6
38%

Phase Distribution

10

Early Stage

6

Mid Stage

0

Late Stage

Phase Distribution16 total trials
Phase 1Safety & dosage
10(62.5%)
Phase 2Efficacy & side effects
6(37.5%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

40.0%

6 of 15 finished

Non-Completion Rate

60.0%

9 ended early

Currently Active

1

trials recruiting

Total Trials

16

all time

Status Distribution
Active(1)
Completed(6)
Terminated(9)

Detailed Status

Completed6
Terminated6
Withdrawn3
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
16
Active
1
Success Rate
50.0%
Most Advanced
Phase 2

Trials by Phase

Phase 110 (62.5%)
Phase 26 (37.5%)

Trials by Status

completed638%
withdrawn319%
active_not_recruiting16%
terminated638%

Recent Activity

Clinical Trials (16)

Showing 16 of 16 trials
NCT01756118Phase 1

A Phase I, Dose-finding Study of BEZ235 in Adult Patients With Relapsed or Refractory Acute Leukemia

Completed
NCT00620594Phase 1

A Phase I/II Study of BEZ235 in Patients With Advanced Solid Malignancies Enriched by Patients With Advanced Breast Cancer

Completed
NCT01195376Phase 1

A Study of BEZ235 in Adult Japanese Patients With Advanced Solid Tumors

Completed
NCT01634061Phase 1

Phase Ib of Abiraterone Acetate Plus BEZ235 or BKM120 in Castration-resistant Prostate Cancer (CRPC) Patients

Completed
NCT01495247Phase 1

Phase Ib/II Trial of BEZ235 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer

Terminated
NCT01856101Phase 2

Study of BEZ235 as Monotherapy in Patients With Transitional Cell Carcinoma After Failure of Platinum Based Chemotherapy

Terminated
NCT03373903Phase 2

Dose Finding Study to Determine if BEZ235 Alone or in Combination With RAD001 Decreases the Incidence of Respiratory Tract Infections in the Elderly

Active Not Recruiting
NCT01717898Phase 1

A Multicenter Phase I/II Trial of Abiraterone Acetate + BEZ235 in Metastatic, Castration-Resistant Prostate Cancer

Terminated
NCT01508104Phase 1

Safety Study of BEZ235 With Everolimus in Subjects With Advanced Solid Tumors

Terminated
NCT01248494Phase 1

PhIb BKM120 or BEZ235+Endocrine Treatment in Post-Menopausal Patients With Hormone Receptor + Metastatic Breast Cancer

Completed
NCT01628913Phase 2

Efficacy and Safety of BEZ235 Compared to Everolimus in Patients With Advanced Pancreatic Neuroendocrine Tumors

Terminated
NCT01453595Phase 1

BEZ235 in Patients With Advanced Renal Cell Carcinoma (RCC)

Terminated
NCT01343498Phase 1

Study of PI3 Kinase/mTOR Inhibitor BEZ235 Twice Daily for Advanced Solid Tumors

Completed
NCT01690871Phase 2

A Phase II Study of Orally Administered BEZ235 Monotherapy in Patients With Metastatic or Unresectable Malignant PEComa

Withdrawn
NCT01290406Phase 2

BEZ235 Trial in Patients With Advanced Endometrial Carcinoma

Withdrawn
NCT01288092Phase 2

BEZ235 Trial in Patients With HER2-(Human Epidermal Growth Factor Receptor 2 Negative) /HR+ (Hormonal Receptor Positive) Metastatic Breast Cancer

Withdrawn

All 16 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
16